Contract Laboratory has received the following incoming Laboratory Testing and Scientific Research Requests which need to be fulfilled! These Laboratory Test Requests are received from a variety of sources ranging from start-up companies to large, multinational Fortune 500 corporations, international organizations, well-respected universities and government agencies that are actively seeking Labs to perform their Laboratory Testing and Scientific Research. If you need a Laboratory, please Submit a Laboratory Testing Request. If you need assistance or have questions email us or call toll free 1-855-377-6821.
URGENT / LONG-TERM TESTING Occupational Health Laboratory needed for a large volume of NIOSH Industrial Hygiene Tests on a long-term basis. The Tests are: NIOSH 5521, NIOSH 5006, Method TO13 Semi-volatile PUF sample; Method TO4 Pesticides PUF samples and EPA Method TO14.
Medical Device Laboratory needed for ANSI/AAMI electrical performance testing of disposable ECG electrodes in compliance with ANSI/AAMI EC12:2000/(R)2015.
Tests to be conducted: * AC impedance * DC offset voltage * Combined offset instability and internal noise * Defibrillation overload recovery * Bias current tolerance
URGENT / LONG-TERM TESTING - US FDA cGMP Pharmaceutical Analytical Chemistry Laboratory needed to analyse one of the excipient sample by Capillary viscometer with the EXACT instrument as detailed in the requirements as given below. NO other instrumentation can be used.
Instrumentation- Automated viscometer equipped with Transparent thermostat with cooler Ubbelohde capillary viscometer, DIN type I Sampler.
Suitable model is the AVS Pro autosampler from Schott in conjunction with a CT 52 transparent thermostat and a CK 300 flow-through cooler from Schott (or equivalent).
Clinical Research Laboratory needed for clinical trial to analyse the effects of sunscreens on the Vitamin D levels in the human body. In order to study this relationship between the sunscreens and Vitamin D levels, the clinical trial will need to perform blood tests before and after a certain buffer period of the candidates using the sunscreen. The candidates will then be checked for Vitamin D levels to analyse the effects the sunscreen had on it and if the new formulation resulted in any Vitamin D increase in the body.
We need a varied group of people from different cultures and back grounds with different lifestyles.
Pharmaceutical Company needs Packaging Laboratory needed for ASTM burst testing on around 90 plastic heat-sealed 8 x 5 packages as part of the qualification for our sealing process according to ASTM F1140 Standard Test Methods for Internal Pressurization Failure Resistance of Unrestrained Packages
MHRA and FDA approved Laboratory needed for testing multiple samples of Glycine, L-Histidine, and other amino acids for nihydrin-positive substance as per the EP 9.4. Alongside this, we will need to test for ammonia. All work will need to be perform to GMP, and the lab have to be MHRA and FDA approved. Samples will be sent from the UK. Alongside this, we will need to sign a three way CDA with our client and yourself. Instrument and analysis expected to commence in June, and testing to last for 3-4 months. Upwards of 30 samples for analysis, this is subject to change.
Clinical Laboratory needed for multiplexing the following human serum/urine analytes (below) in multiple samples of multiple cancers. 1. CCL2 2. CCL5 (missing in BioRad Human Chemokine panel) 3. CCL18 (missing in BioRad Human Chemokine panel) 4. CCL25 5. CXCL9 6. CXCL10 7. CXCL11 8. CXCL12 9. CXCL13 10. CXCL16 11. IL-1beta 12. IL-6 13. IL-10 14. IL-27 (missing in BioRad Human Chemokine panel) 15. Leptin (missing in BioRad Human Chemokine panel) 16. LTA/TNF-beta (missing in BioRad Human Chemokine panel) 17. LTB/TNF-c (missing in BioRad Human Chemokine panel) 18. RANKL/TNFSF11 (missing in BioRad Human Chemokine panel) 19. TWEAK/TNFSF12 (missing in BioRad Human Chemokine panel) 20. TNF-alpha 21. VEGF (missing in BioRad Human Chemokine panel) 22. CA15-3 (BR75) 23. CEA/CEACAM-5 (BR30) 24. CX3CL1 25. CCL11 26. CXCL8
LONG-TERM TESTING Biotech Start-up needs CLIA certified laboratory with State-of-the-art UHPLC-MS/MS system required. for Liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurements required for a multiplexed panel of biomarkers. Looking for a long-term partner laboratory to work collaboratively with our biotech start-up with an increasing demand for routine testing running from 100 -1000 samples a month.
Pharmaceutical Laboratory needed for nasal spray analysis tto confirm specification including the following: Droplet Size Distribution (micro meter) at 6cm specification Limit d10 NMT 50 micro meter? d50 NMT 90 micro meter d90 NMT 160 Micro meter Span factor at 6cm %Droplets less than 10µm NLT 1 NMT 4%
Faten Al Hasanat
Clinical Center needs Bioanalytical Laboratory for multiple tests on 30 stem cells samples:
1.Determination of Hyaluronic Acid, Agarose Gel Electrophoresis 2.Hyaluronic Acid Western Blotting 3. Heavy Chain of HA Western Blotting 4.PTX3 (Pentaxrin 3 Protein) Western Blotting 5. Hyaluronic Acid Immunofluroscence 6. Collagen IImmunofluroscence 7.Fibronectin Immunofluroscence 8. LamininImmunofluroscence 9. Laminin Immunofluroscence
LONG-TERM TESTING Experienced Preclinical Contract Research Organizations CROs needed with human in vitro neuromuscular junction assay (NMJ) system using iPSC derived from ALS patients to evaluate compounds.
In this regard please provide the following info: 1. Your experience with the technique 2. Example deliverable, if available 3. Facilities and staff expertise 4. Publications 5. Any other information that would help us make a decision with whom to proceed
Microbiology Laboratory needed for comparative efficacy testing on Disinfectant (1 Liquid Disinfectant (1 Liquid & 1 Powder) for following viruses and bacteria as per USP Bacteria E. coli Pseudomonas aeruginosa Candida albicans Aspergillus brasiliensis B. subtilis Mycoplasma gallisepticum Salmonella pullorum Virus Avian influenza (orthomyxo H3N2 and H5N) Infectious bronchitis by Corona virus Infectious brusal disease (NE) by avibirnavirus
PRODUCT DEVELOPMENT Bioanalytical Laboratory needed for multiple testing including small sample batch formulations of a powdered biological product.. Required testing includes
1. Amino acid analysis 2. Elemental Analysis 3. Peptide Mapping 4. Organic materials testing of taurine, aminohexose, cholesterol, free protein 5. Final blend development and mixing of amino acids and keratin protein powder
Three Bioanalytical Laboratory sites needed to conduct an in-vitro precision (repeatability and reproducibility) study of an IVD using banked serum samples that will be provided by the study sponsor. Each site will require three testers to evaluate 30 samples each per day for five consecutive day, for a total of 450 samples per test site. A lab site is also needed to perform an interference study for the IVD.
LONG-TERM TESTING Bioanalytical Laboratory needed for testing a single compound of interest at a few serial dilutions to determine if it is an inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1), preferably using a cell-based assay, but in vitro using purified Tdp1 or cell extract also will suffice. Additional compounds to be tested in due course depending on results of first test.
US FDA Medical Device Laboratory needed for cleaning validation and steam sterilization studies for medical implant and instrument set. Set is in rigid reusable three tray Sterilization case. Implants are titanium cages in a caddy. Hardest to clean device is a disc shaper.
LONG-TERM TESTING Pharmaceutical Analytical Chemistry Laboratory needed for ongoing HPLC analysis of about 40 samples a month on any of the following: Rhynchophylline, Speciophylline PAYNANTHEINE, SPECIOGYNINE, SPECIOCIALITINE or Mitraphylline. We have a about 40 samples that need run then on going of about the same volume per month.
Microbiology Laboratory needed that specializes in influenza viruses for efficacy testing the efficacy of our product on a variety of virus contaminated substrates (coupons) as well as the durability of our product in restricting/eliminating recontamination by the virus on the same or similar treated substrates (coupons).
LONG-TERM TESTING Clinical Toxicology Laboratory needed for a wide window. of substance of abuse testing for large volume of samples. Drug Substances are substances are;
Marijuana and its deirvados (hashish and others)
Cocaine and its derivatives (crack, merla and others)
Matanfetaminas (speed, ice and others)
Ecstasy (MDMA, MDA and EVE)
Opiate (heroin, morphine, codeine and others)
Clinical Research Laboratory needed for clinical panel study for fingernail growth with measurement of microcirculation under a lacquered fingernail against a control. .This may need need to be done via laser doppler as the nail lacquer provides a barrier that basic microscopic imaging cannot go past
Medical Device Laboratory needed to perform testing as per EN 13544-2 (Respiratory therapy equipment. Tubing and connectors) - A.3 Test method Resistance to gas flow of the tubing - A.4 Method of test for security of connection between end connector and tubing - A.6 Method of test for resistance to kinking
LONG-TERM TESTING Clinical Diagnostic laboratory needed that runs TB assays/tests to conduct a comparison study of TB sample processing methods. - samples would then be run on MGIT, LJ. Would also like to look at Xpert and LPA assays as well if available in the lab.
Medical Device Laboratory needed for ASTM Testing of personal lubricants for compatiability with natural rubber latex, polyurethane and synthetic condoms as per ASTM D7661-10. Standard Test Method for Determining Compatibility of Personal Lubricants with Natural Rubber Latex Condoms
Organic Farm developing aromatic and medicinal herbs for essential oil and absolute production needs Analytical Chemistry Laboratory for testing to determine the chemical characteristics and chromatographic analysis of wild Thyme essential oil known as Oreganum stratum
Large Organization needs Medical Device Laboratory for comparison study on 3 or 6 Surgical gowns suppliers testing against BS EN 13795 , including Wet Penetration , Dry Penetration, Mircobial cleanliness , particulant matter& linting , liquid penetration and tensile strength (with various BS En references to these)
Medical Device Laboratory needed for Clinical Study urine analysis for concentration of leukocytes. The following needs to be performed: Negative urine is spiked with a specific concentration of Leukocytes There are 9 concentrations of Leukocytes 30 applicants (urine test strips) must be tested at each one of the 9 concentrations. These 30 test strips must represent 3 different lots (10 strips from Lot 1, 10 strips from Lot 2, 10 strips from Lot 3) 4 different mobile phone models will be used to test the 30 applicants at each concentration
Large Healthcare Company needs Pharmaceuticals Laboratory for SMEPAC/Surrogate powder test as part of performance testing of equipment. using lactose monohydrate as surrogate powder. The test will be performed on 3 units: 1 isolator (OEL: 0.1ug/m3) and 2 downflow booths(OEL: 100ug/m3). The estimated total number of samples for each unit is 26.
Medical device manufacturer seeking testing compliant with ISO 15747:2010, Plastic containers for intravenous injections relating to safe handling and the physical, chemical, and biological testing of plastic containers for parenterals. Please inquire for further information on the product we are testing.
Laboratory needed for ASTM seawater biodegradability testing of biomaterial composites to determine if the materials degrade in marine water to ASTM D6691 Standard Test Method for Determining Aerobic Biodegradation of Plastic Materials in the Marine Environment by a Defined Microbial Consortium or Natural Sea Water Inoculum
Clinical Laboratory needed for Amino Acid bioavailability study (approximately 864 samples) with bioanalysis for Alanine, arginine, aspartic acid, carnitine, cystine, glycine, glutamine, histidine, isoleucine, leucine, lysine, methionine, proline, serine, taurine, tyrosine, threonine, tryptophan, valine
LONG-TERM TESTING Dietary Supplement Analytical Chemistry Laboratory needed for purity testing of growth hormones
ostarine (mk-2866) ibutamoren (mk-677) cardarine (gw-501516) ligandrol (LGD-4033) andarine (s4) yk-11 rad-140 s-23 sr9009
We are looking for a company that has already the standards of each hormones.
Large Corporation needs Consumer Research Laboratory for consumer panel flavor study on beverage can coatings to determine if the specific type of can coating is changing the taste of the beverage over time to know if taste test participants can distinguish the difference in the taste of the beverage based on the type of beverage can coating used.
Bioanalytical Laboratory needed for assay of select inflammatory biomarkers to confirm the presence of inflammatory cytokines: CXCL1, TNF alpha and IL1b in murine corneal tissue. The frozen specimens of murine corneal tissue subsequent to treatment with LPS in order to induce corneal inflammation. We are requesting assay of select inflammatory biomarkers to confirm presence of inflammatory cytokines. We anticipate submission 10 specimens for analysis. Analyses should be done in duplicates.
Pharmaceutical company needs a laboratory capable of identification testing on a couple of petrochemical products such as mineral oil and petrolatum via maybe GC-FID. Our purpose is to link potential grade of mineral oil and petrolatum in a commercial ointment product.
Bioanalytical Laboratory needed for dose response tests and coagulation assays to determine if there are anti-coagulation properties in 10-20 small molecule viral inhibitors compounds. Due to the chemical nature of these compounds, we are concerned that they may have anti-coagulation properties. As such, we are looking to get information and pricing on coagulation assays to see whether these compounds alter normal blood coagulation.
Analytical Chemistry Laboratory needed for pheromone concentration testing of 18 pheromones in (human) pheromone compounds: 1 alpha-androstenol 2 androstadienol 3 androstadienone 4 androstanone 5 androstenone 6 androsterone 7 androsterone potassium sulfate 8 ß-androstAnol (Molecule A) 9 ß-androstenol 10 dehydroepiandrosterone sodium sulfate 11 dehydroisoandrosterone 12 dihydrodeoxycorticosterone 13 DHEAS 14 epiandrosterone 15 estratetraenol 16 phenylandrosten-3a-ol 17 (trace) tetrahydrodeoxycorticosterone 18 human copulins
FDA GLP Medical Device Product Safety Laboratory needed for ISO 10993-1 biocompatibility studies for implantable bone graft substitutes (granules), xenograft (from bovine bone) and a biphasic calcium phosphate Cytotoxicity- Sensitization- Irritation or intracutaneous reactivity- Systemic toxicity- Subchronic toxicity- Genotoxicity- Implantation
US Nutraceutical Manufacturer needs Dietary Supplement Laboratory for confirmation testing of the Certification of Analysis of HPMC capsules it purchases to encapsulate a nutraceutical. The manufacturer provides a COA for each lot. We need to verify results on the COA which includes identification of HPMC.
LONG-TERM TESTING Nationwide medical network needs clinical diagnostic laboratory with PCR capabilities for testing 30 plus pathogens and antibiotic resistance with a turnaround time of 24-72 hours along with other Repertory, Urology, Wound Sequencing,Nail Clippings, and Gastrointestinal testing.
LONG-TERM TESTING Pharmaceutical Laboratory needed for raw material release and vendor qualification testing with full USP/NF/Ph.Eur. testing and method verification for three lots of all the following materials Materials: Cholesterol Sucrose L-Histidine Ammonium Sulfate Sodium Succinate (Disodium Succinate Hexahydrate) Vitamin E (tocopherol) Methanol Alcohol (Ethanol) Methylene Chloride Hydrochloric Acid Sodium Hydroxide
Please be sure to read the requirements and submit the information requested.
Medical Device Laboratory needed for ASTM Testing of Protective Clothing to the following standards: ASTM F1670/F1670M Standard Test Method for Resistance of Materials Used in Protective Clothing to Penetration by Synthetic Blood, ASTM F1671/ F1671M Standard Test Method for Resistance of Materials Used in Protective Clothing to Penetration by Blood-Borne Pathogens Using Phi-X174 Bacteriophage Penetration as a Test System, ASTM D882 Standard Test Methods for Tensile Properties of Thin Plastic Sheeting, ASTM F1342/ F1342M Standard Test Method for Protective Clothing Material Resistance to Puncture, ASTM D1004 Standard Test Method for Tear Resistance (Graves Tear) of Plastic Film and Sheeting
Medical Device Laboratory needed for cleaning and validation studies to support our class II medical device 510(k) submissions to the FDA- will need to go over specific instructions for use, the level of disinfection and the type of microorganisms chosen for the test.
Analytical Chemistry Laboratory needed to test Argon (gas) as per European Pharmacopeia (Ph.Eur.). Specifically we are interested in impurities determination by GC as described in EP monograph for Argon: GC with stainless steel column 4 m x 4mm and molecular sieve for chromatography R (particle size 150-180 micras, pore size 0.5mm). Detection: discharge ionisation. Limits for impurities as per our dossier will be: - oxygen: not moret than 5.0 ppm v/v - total hydrocarbons (methane): not more than 0.5 ppm v/v - nitrogen: not more than 5.0 ppm v/v
Medical Device Laboratory needed for testing of a filter developed for a medical application. The filter consists of a pleated element to trap particulates and a carbon-based filter to trap VOC's. The following testing is required:
1 - A trace showing the % retention of 1u, 2u, 3u particles over time @ 9 liters/min initial flow, and flow decrease over time. 2 - In a smoke-filled environment, trace flow decrease vs. time starting at 9 l/min to 6 l/min to 0 flow.
3 - Evaluate filter behavior in a humid environment - 98.6 deg F @ 95% humidity
4 - Evaluate the filter's removal of noxious odors
5 - In a smoke-filled chamber, evaluate the filter's particulate removal in recycle mode as a function of time (perhaps via light scattering and Beer's Law?).
Histology Laboratory needed for histological (H& E) studies on following area 1. Cerebrum Male rat control × 200 & × 400 2. Iscahemia for Carotid Vessel for 25 minutes × 200 & × 400 then perfusion for one hour 3.Ischaemia for 3-5 minutes then perfusion for one hour ×200 ×400
LONG-TERM TESTING Genetics Laboratory that can handle large volumes of testing needed for Pharmacogenetic and Hereditary Cancer testing:
PGx- All CYP, Factor II Factor, MTHFR, SLCO1B1, VKORC1 - Swab Testing Only
Hereditary 28 Panel Cancer Screening Swab test + individual report.
FDA cGMP/ ISO 17025 Pharmaceutical Microbiology Laboratory needed for USP monograph, stability and compliance testing of sterile and non-sterile compounded pharmaceuticals to 21 CFR parts 210 and 211, the Compounding Quality Act and USP <797> for sterile and <795>.for non-sterile. . Laboratory must have validated potency method for APIs. including : o 201070 BENZOCAINE 20% / LIDOCAINE 10% / TETRACAINE 10% EMULSION CREAM o 201010 BENZOCAINE 20% / LIDOCAINE 10% / TETRACAINE 10% EMULSION o 201020 LIDOCAINE 23% / TETRACAINE 7% CREAM o 011021 NIACINAMIDE 4% / TRETINOIN 0.05% CREAM o 011013 NIACINAMIDE 4% / TRETINOIN 0.025% CREAM ? For microbial/ yeast/mold and endotoxin testing they must have a rapid scan method)
Pharmaceutical Analytical Chemistry Laboratory needed for conducting studies on the Active Pharmaceutical Ingredients APIs in an oil in water emulsion. We need to arrive at following conclusions by morphological/physical/chemical testing etc
1. Whether APIs are dispersed or solubilized (both APIs). 2. Phase in which each API is present (dispersed phase of emulsion or continuous phase of emulsion) 3. Particle size of API (for dispersed API). Separate PSD for each API if both are dispersed. 4. Globule size of emulsion.
LONG-TERM TESTING Medical Device Microbiology laboratory of Bioburden and sterility testing for implantable medical device. WE will send product for testing after sterilization using gamma radiation as the method of sterilization. 20 samples/ product family (4 families) every quarter.
LONG-TERM TESTING Microbiology Laboratory needed for MIC testing of pharmaceutical test articles with or without 5% Fetal Bovine Serum (FBS) with the following test organisms:
1. S.Aureus ATCC 29213 2. S. Aureus 33591 3. P. Aeruginosa ATCC 27853 4. P. Aeruginosa 1674623
Test Articles: Collodial Ag nanoparticles + Zinc citrate in sterile water suspension. We will supply all test articles.
1. Ag 30 ppm 2. Ag 100 ppm 3.Ag + Zn at 30 ppm each 4. Ag+ Zn at 100 ppm each 5. Ag at 30 ppm and Zn at 2000 ppm 6. Ag at 100 ppm and Zn at 2000 ppm 7. Citrate (vehicle control) 8. Ciprofloxacin (positive control)
Bioanalytical Laboratory needed grow Human Primary Trophoblast cells with serum and without serum for varying amounts of time (0, 24hrs, 48hrs, 72hrs, and 96hrs). Then immunofluorescence stain the cells with GLUT8 and Humanin for images.
We are looking to have a data point for every combination of serum, time,and staining: serum: with and without time(hrs): 0 (control), 24hrs, 48hrs, 72hrs, and 96hrs staining: GLUT8 and Humanin (if possible, also co-staininng with lysosomal markers)
We also need to have a non-isotype IgG negative control.
For immunofluorescence images, we would like at least 40x magnification.
Healthcare manufacturer needs Microbiology Laboratory for Bacterial Suspension Testing using P. aeruginosa. Specifications are: Suspensions diluted to 10^-6 and 10^-7 in sterile saline, pour plated in 0.2 ml amounts in Trypticase Soy Agar and incubated 24-48 hours at 33C to 37C. T0: 4.3 x 10^7 7.6 x 10^8 CFU/ml T6: 4.6 x 10^7 7.6 x 10^8 CFU/ml
LONG-TERM TESTING Small business that manufactures topical homeopathics in small batches needs microbiology laboratory for USP Batch Testing to USP Standards: USP 61 MICROBIOLOGICAL EXAMINATION OF NONSTERILE PRODUCTS: MICROBIAL ENUMERATION TESTS and/or USP 62 MICROBIOLOGICAL EXAMINATION OF NONSTERILE PRODUCTS: TESTS FOR SPECIFIED MICROORGANISMS
Plant based dietary supplement manufacturer need bioanalytical laboratory for blood testing for the measurement of NAD in human blood (Nicotinamide adenine dinucleotide - a coenzyme found in living cells). We are interested in proper quantitative measurement of NAD in blood, and from our research we came to know that HPLC is one of the methods to measure it.
FDA registered and cGMP compliant analytical chemistry laboratory needed for latex and/or DEHP (Di Ethyl Hydroxy Phthalate) testing on rubber closures (stoppers) or syringe pistons used for injectable pharmaceuticals. We are not currently looking for a full extractable/leachable study, just the ability to test for the specific items.
Skincare company needs dermatology clinical research laboratory for development of a protective cream for prolonged work in gloves that helps avoid excessive sweating on the skin of hands, restrains the growth of harmful microorganisms (bacteriostatic effect), and improves microcirculation in the vessels of the skin of hands, protects cells from harmful factors. This product has 3 main properties, which need to be confirmed: 1) Antiperspirant effect 2) Improvement of cutaneous respiration 3) Bacteriostatic effect We are planning to register this product as a cosmetic product. So we have to confirm these claims with test reports by 1) Antiperspirant effect was confirmed by gravimetric method and method the probe of Minor (iodine-starch test). The effect of the product was shown to be lasting up to 4 hours. 2) Skin respiration (cutaneous re
Medical Devices Laboratory needed for performance and microbiology testing of medical textiles to EN 13795: 2011 A1: 2013 including Tensile strength - dry and wet - EN 29073-3:1992 Burst strength - dry and wet - EN 13938-1Resistance to fluid penetration - EN 20811Cleanliness microbial - EN 1174 (replaced by EN ISO 11737)Cleanliness particulate matter - ISO 9073-10Linting - ISO 9073-10 Resistance to microbial penetration - dry - ISO 22612Resistance to microbial penetration - wet - ISO 22610.My main question is, if you are able to perform such tests?
Microbiology laboratory needed to run BACTEC blood culture incubation on a variety of blood samples inoculated with different strains and concentrations of Staphylococcus aureus. Our design would necessitate approximately 30-40 samples be run. We are interested in time to threshold of detection and which samples do not reach threshold at 5 days.
Agriculture biotechnology company needs EPA GLP environmental toxicology laboratory for 4 ecotoxicology studies for a botanical active substance under EU requirements: - Biodegradable test (OECD 301) - Chronic toxicity study on bees - Bee larvae brood study - Typhlodromus piry, Aphidius rophalosiphi, Chrysoperla carnea, Coccinela sectempunctata. We would really appreciate a quotation for these four tests. Best regards
University researcher needs laboratory to perform in-vitro study of antiulcer activity of plant extract according to the methodology methodology is Inhibition of Histamine stimulated Adenylate cyclase from gastric mucosa using guinea pigs. The in vitro potencies of H2-antagonists can be evaluated using determinations of adenylate cyclase activity in membrane preparations of guinea pig mucosa after stimulation with histamine. Reference: Drug Discovery and Evaluation, by H. G Vogel, pg. no. 861
Genetics laboratory for proteomic analysis of a raw material product, to identify the gene source and expression vector, and perform peptide sequencing to obtain amino acid sequence of the material present in the samples. Probably LC ESI MSMS or LC MALDI MSMS or combination of the two.
Virology laboratory needed for performing PCR analysis for many different rabbit and porcine viruses based on the guideline (CPMP_BWP_3354_99), as follows. CPMP_BWP_3354_99: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003222.pdf:
For rabbit viruses: Rabbit rotavirus, Reovirus type 3, Poxviruses, Rabbitpox (RPXV), Myxomatosis virus (MYXV), Shope fibroma virus, Rabbit haemorrhagic disease virus (RHDV), Rabbit papillomaviruses, Rabbit kidney vacuolating virus, Herpes cuniculi Adenovirus, Encephalomyocarditis virus, Borna disease virus, Sendai virus, Simian Parainfluenza (SV-5), Pneumonia virus of mouse (PVM).
For porcine viruses: Enveloped Viruses, Influenza virus A (,airborne), Nipah Virus & Menagnel Virus (paramyxoviruses), Vesicular Stomatitis Virus (aerosols), Pseudorabi
Medical Device laboratory needed for surgery simulation and functional testing of sterile surgical packs after sterilization including on: - aged samples (2 years past used by date) for: appearance (noting any signs of discolouration) - functionality (whether the components within the pack show no adverse affect on the brittleness of the plastics, bungs breaking up in syringes etc).
Life Science company needs laboratory for NMR spectras to help determine if there are steroimpurities. Spectras at NMR: 1H-13C HSQC 400-500MHz. We need one spectrum at room temperature and another at a different temperature (>15C degree difference). So 4 spectra total, 1H, 13C and at two temperatures.
Medical device laboratory needed for drug compatiblity testing and testing of parenteral IV containers to ISO 15747:2010 which contains requirements that relate to the safe handling and the physical, chemical and biological testing of plastic containers for parenterals. ISO 15747:2010 is applicable to plastic containers for parenterals having one or more chambers and having a total nominal capacity in the range of 50 ml to 5 000 ml such as film bags or blow-moulded plastic bottles for direct administration of infusion (injection) solutions.
On the same lines I need to collaborate to test the following in my products:
(i) Ideal Uniform Self Collapsibility (ii) logarithmic volume measurement for infused volume (iii) No Exchange of Hazardous Contaminants with Environment (iv) Residual Volume in Container (v) No Suck Back in th
Medical Device Laboratory needed for conducting safety and efficacy study of ear candle which assists with ear wax removal. The study should show that the ear candles do not cause burns, do not produce a suction or vacuum in the ear and do not introduce any contamination into the ear.
FDA Medical device microbiology laboratory needed to perform multi-use testing assay on a liquid bandage medical device product. This assay is similar to USP51 testing and will use the 5 specified microbes, but it must have repetitious bioburdens applied to simulate a multi-use, (ie. ~50 uses) environment for the non-sterile liquid bandage product. The produc unit and the applicator with which bioburden contamination will occur is a propylene brush.
LONG-TERM TESTING FDA GLP textiles laboratory needed for testing to provide profilometry data on our fabric samples used in medical / performance clothing products. We are interested in determining if this analysis could help us quantify texture between fabric samples.
Pharmaceutical bioanalytical laboratory needed for Large Volume Parenteral (LVP) assay, related substances, degradation and impurity profile of amino acid infusion 7%, 8% & 10% by validated HPLC/ UHPLC test method.
Technical Requirements include:
- Sharpen peaks individually - Good resolution between the peaks (at least 2) - Acceptable theoretical plates (More than 2000) - Constant retention time for each analysis
FDA Medical Device Laboratory needed for ISO VOC, particulate, CO and CO2 testing for ventilator components with dry gas pathway contact for emergency and transport ventilator to ISO 10993-1, Biological evaluation of medical devices - Part 1: Evaluation and testing within a risk management process
FDA GLP Medical Device Laboratory needed for performance testing of medical resuscitator to ISO 10651-4 Manual Resuscitator. The test to be performed include: Delivered O2 concentration - Expiratory resistance - Inspiratory resistance - Patient valve - (Dead space - Tidal Volume
LONG-TERM TESTING Bioscience company needs bioanalytical laboratory for raw material, in-process, and final product MAT or cell-based endotoxins testing with assays that are not based on the LAL or rProtein C methods for endotoxin detection. The liquid formulation of both proteins and polymers. We would need to have endotoxin testing performed with a MAT or cell-based assay, since we already know that protein interferes with the LAL and rProteinC methods.
Pharmaceutical laboratory needed for accelerated stability studies to verify the 24 month expiration date of unit dose OTC medication. Company is repackaging ibuprofen 200 mg soft gels that the manufacturer has packaged in bottles into 2 pills per unit does in paper-poly foil pouch.
Clinical laboratory needed to perform clinical study of product that lowers your blood alcohol content with 150 people with 100 being given the product and 50 a placebo. The test subjects will have to drink three 1.5 ounces of vodka in an hour. Their blood alcohol will need to be tested with 20 individual DOT certified breathalyzers every half hour. The study will need to last 3 hours from beginning to end.
Bioscience company needs laboratory for simple phytochemical screening for the presence of various classes of phytochemicals in an aqueous sample., The compound classes include: Alkaloids, Bioflavonoids, Cardiac glycosides, Carotenoids, Phenolics, Saponins, Sterols, Terpenoids, etc.
Medical device laboratory needed for cleaning validation study of the water cleaning cycle of a plastic covered electronic tracking device . Simulation of the a 150C temperature water cleaning cycle for 30 minutes over a 500 cycles tis needed to ensure that this product can withstand the temperature, time and cycles. I would provide a fixture with 10 units for this test
FDA GLP bioanalytical laboratory needed for bioanalysis of bovine IgA content of spray-dried bovine plasma, whey protein, and animal feed (containing bovine plasma/whey protein) by HPLC chromatography. The samples would consisting of 1 plasma sample, 3 whey samples, and 3 animal feeds.
Medical Device laboratory needed for ISO pre-compliance filter testing on medical ventilation module in accordance with ISO 23328-1:2008 standard, Breathing system filters for anaesthetic and respiratory use Part 1: Salt test method to assess filtration performance The standard specifies a salt (NaCl) filtration challenge.
Medical electrical laboratory needed for IEC testing of sterile electrosurgical products to IEC 60601-1, Medical electrical equipment - Part 1: General requirements for basic safety and essential performance and IEC 60601-2-2 Particular requirements for the basic safety and essential performance of high frequency surgical equipment and high frequency surgical accessories
Biosciences company needs bioanalytical laboratory for in-vitro anti-biofilm activity testing by Minimal Biofilm Eradication Concentration (MBEC) assays using peg lid containing biofilm plates on aqueous samples. Biofilm producing bacteria of interest are: initially - staph aureus, with others to follow.
Preclinical laboratory needed for method development of an immunofluorescence method to be used for nuclear beta catenin and applied to preclinical studies with human cancer tissue and to clinical trial specimens.
Due to nature of drug action, method must be specific for detection of nuclear, and not cytosolic, beta catenin. Method will require confocal microscope. We have the antibody for nuclear beta catenin available commercially.
Bioanalytical laboratory needed that can analyse the substance identity of two different enzymes for the purpose of the European REACH Regulation. The following characteristics should be analysed:
-Composition of the substance (purity, impurities, stabilizing agent, inhibitors or other additives*) Example for typical constituents, Additives, Impurities:
-Enzyme, e.g. Amylase, - alpha-amylase (active enzyme protein)
-Protein as a constituent of enzyme deriving from the fermentation or extraction process
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
-Spectral or chromatographic (HPLC, GC
Preclinical Contract Research Organization CRO needed for Non-GLP , in-vivo anti-pyretic testing of a powdered based analgesic drug. Company would like to consult with the CRO on the experimental design. It's first option is in rats, but they may consider other animal species.
Bioanalytical laboratory needed to conduct 3 studies as part of food clinical trials including:
1- Study of the changes in faecal bacteria populations using 16SrRNA probes labelled with Cy3 for specific bacterial groups or the nucleic acid stain DAPI for total bacterial counts. The bacterial groups selected for enumeration will be Bifidobacterium spp., Bacteroides/Prevotella spp., Lactobacillus/Enterococcus spp., Clostridiumcoccoides- Eubacterium rectale group, Clostridium histolyticum group, and Atopobium cluster including most Coriobacteriaceae species, using the specific probes Bif164, Bac303, Lab158, Erec482, His150, and Ato291, respectively 2. Fluorescence insitu Hybridisation (FISH), as described by Rycroft et al. (2001) and Daims et al. (2005). Briefly, faecal samples (375?l) fixed in 4% paraformaldehyde (pH7.2) overnight at
LONG-TERM TESTING Food laboratory needed for liquid meal replacement analysis for electrolyte content (ex. sodium, potassium, calcium), fat content (saturated/unsaturated/omega), and glycemic load. One sample would also require measurement of chondroitin/glucosamine levels.
FDA GMP medical device laboratory needed for testing to support FDA 510(k) based on FDA-recognized consensus standards: 3-80 AAMI ANSI ISO 81060-1:2007/(R)2013 - Non-Invasive Sphygmomanometers - Part 1: Requirements And Test Methods For Non-Automated Measurement Type and 3-96 ISO 81060-1 First Edition 2007-12-01 Non-Invasive Sphygmomanometers - Part 1: Requirements And Test Methods For Non-Automated Measurement Type
LONG-TERM TESTING FDA GMP bioanalytical laboratory needed for developing and validating bioassays in bulk substance high-titer antibody biologics (PPM sensitivity) including bioanalysis for antifoam residuals and an assay for Pluronic F68 excipient level (quantitative). Osmolality by vapor pressure.
LONG-TERM TESTING Private clinical trial and internal medicine practice needs CLIA certified clinical laboratory to perform all routine clinical blood analysis for both reasearch / clinical study qualification and montitoring as well as the private internal medicine practice.
FDA GMP pharmaceutical analytical chemistry laboratory needed for mass spectrometric identification analysis of our reference standards. A high resolution MS (e.g. Orbitrap instrument, Time-Of-Flight instrument) is required in order to extract an exact mass of analyzed substance and identify the molecular formula from raw data.
Medical device laboratory needed for ISO testing of blue light and UV ray blocking optical lenses including ISO 8980-3, Ophthalmic Optics - Uncut Finished Spectacle Lenses - Part 3 Transmittance Specification and Test Methods.
ISO 14889, Ophthalmic Optics - Spectacle Lenses - Fundamental Requirements for Uncut Finished Lenses.
ISO 17025 medical device laboratory needed for full VDmax25 sterilization validation on titanium orthopedic screws to ISO 11137 including bioburden validation (correction factor), bioburden determination on three lots of product, delivering the verification dose, sterility testing, microbiological identification and BF testing. We are also seeking BF testing on a titanium intramedullary nail.
Medical Device laboratory needed for passive ligating clip medical implant testing to several ISO and IEC standards including:
F2052 Test Method for Measurement of Magnetically Induced Displacement Force on Medical Devices in the Magnetic Resonance Environment
F2119 Test Method for Evaluation of MR Image Artifacts from Passive Implants
F2182 Test Method for Measurement of Radio Frequency Induced Heating On or Near Passive Implants During Magnetic Resonance Imaging
F2213 Test Method for Measurement of Magnetically Induced Torque on Medical Devices in the Magnetic Resonance Environment
IEC 60601-2-33 Medical Electrical Equipment Part 2-33: Particular Requirements for the Safety of Magnetic Resonance Equipment for Medical Diagnosis,
ISO 14971 Medical Devices Application of Risk Management to Medical Devices,
LONG-TERM TESTING Large pharmaceutical company needs analytical chemistry laboratory for weekly testing of four different compound lots: a water wash, a PBS wash, an IPA wash and a Hexane wash. Water wash - Tetramethylendiamine, acrylic acid, polyethylene glycol, methylenebisacrylamide and acrylamide. PBS wash - dyes (red, blue, yellow, orange and black), aminoethyl methacrylate, bisacrylamide and glycerol methacrylate, PEG 10K, SPAN80, Hexane, IPA, tetramethylendiamine. Hexane wash - Hexadecane and SPAN 80 IPA wash - Hexadecane
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