Contract Laboratory has received the following Clinical Laboratory Test Requests which need to be fulfilled! These Laboratory Test Requests are received from a variety of sources ranging from start-up companies to large, multinational Fortune 500 corporations, international organizations, well-respected universities and government agencies that are actively seeking Independent, Third-Party Clinical Laboratories to perform their Clinical Testing, Analysis, Assays, Product Development, Scientific Research Experiments, Inspections, Certifications, and Engineering Projects. If you are a Clinical laboratory that would like more information on these Clinical projects, please visit our registration page or call toll us free 1-855-377-6821.
Test Request 17-01824
Histology Laboratory needed for histological (H& E) studies on following area
1. Cerebrum Male rat control × 200 & × 400
2. Iscahemia for Carotid Vessel for 25 minutes × 200 & × 400
then perfusion for one hour
3.Ischaemia for 3-5 minutes then perfusion for one hour ×200 ×400
Test Request 17-01752
Cosmetics Clinical Research Laboratory needed for Clinical Efficacy testing on an Eye Lash Product including:
1. 25-30 subjects
2. 30 day study with evaluation at weekly intervals
3. Photographic Assessments
4. Claim to substantiate: Added length and density noticed after 14 days and full benefit after 30 days .
5. Based on Raw Material at 10%
6. Self-evaluation questionnaire
7. No blind or placebo
8. Testing intervals at Base, week 1,2,3 and 4.
Please provide a quote based on the criteria and any additional service that may be useful in validating our claims.
Test Request 17-01622
Skincare company needs dermatology clinical research laboratory for development of a protective cream for prolonged work in gloves that helps avoid excessive sweating on the skin of hands, restrains the growth of harmful microorganisms (bacteriostatic effect), and improves microcirculation in the vessels of the skin of hands, protects cells from harmful factors. This product has 3 main properties, which need to be confirmed: 1) Antiperspirant effect 2) Improvement of cutaneous respiration 3) Bacteriostatic effect We are planning to register this product as a cosmetic product. So we have to confirm these claims with test reports by 1) Antiperspirant effect was confirmed by gravimetric method and method the probe of Minor (iodine-starch test). The effect of the product was shown to be lasting up to 4 hours. 2) Skin respiration (cutaneous respiration) is the property, which includes all kinds of exchange processes in the skin (supplying the skin with oxygen), metabolic processes (synthesis of collagen and elastin), regeneration processes and improving the viability of the skin cells when exposed to harmful environmental factors. These properties are provided by the 2 components of product (caffeine and ginger extract) increasing ATP synthesis in the cell (under the influence of acetylglutamine), as well as the microcirculation in the skin. The effect of product to improve cutaneous respiration was confirmed by laser Doppler flowmetry. 3) Bacteriostatic effect the temporary suppression of the ability of microorganisms to reproduce (not the same as antibacterial action!). This effect is side-effect, because the composition of the product contains no antibacterial ingredients. The effect is achieved by the common action of the antiperspirant complex.
Test Request 17-01178
Clinical laboratory needed to perform clinical study of product that lowers your blood alcohol content with 150 people with 100 being given the product and 50 a placebo. The test subjects will have to drink three 1.5 ounces of vodka in an hour. Their blood alcohol will need to be tested with 20 individual DOT certified breathalyzers every half hour. The study will need to last 3 hours from beginning to end.
Test Request 17-01125
Preclinical laboratory needed for method development of an immunofluorescence method to be used for nuclear beta catenin and applied to preclinical studies with human cancer tissue and to clinical trial specimens.
Due to nature of drug action, method must be specific for detection of nuclear, and not cytosolic, beta catenin. Method will require confocal microscope. We have the antibody for nuclear beta catenin available commercially.
Test Request 17-01120
Test Request 17-01100
Bioanalytical laboratory needed to conduct 3 studies as part of food clinical trials including:
1- Study of the changes in faecal bacteria populations using 16SrRNA probes labelled with Cy3 for specific bacterial groups or the nucleic acid stain DAPI for total bacterial counts. The bacterial groups selected for enumeration will be Bifidobacterium spp., Bacteroides/Prevotella spp., Lactobacillus/Enterococcus spp., Clostridiumcoccoides- Eubacterium rectale group, Clostridium histolyticum group, and Atopobium cluster including most Coriobacteriaceae species, using the specific probes Bif164, Bac303, Lab158, Erec482, His150, and Ato291, respectively
2. Fluorescence insitu Hybridisation (FISH), as described by Rycroft et al. (2001) and Daims et al. (2005). Briefly, faecal samples (375?l) fixed in 4% paraformaldehyde (pH7.2) overnight at 4?C were then centrifuged at 1500 ×g for 5 min, washed twice with phosphate buffer saline (PBS0.1M,pH7.0), re-suspended in a mixture of PBS/99% ethanol (1:1v/v) and stored at ?20?C for up to 3 months. For the hybridisations, 20?l of each sample was pipetted onto Teflon-and poly-l-lysine-coated, six-well (10mm diameter each) slides. Slides were dried at 46C for 15 min and then submerged in a series of ethanol solutions (50, 80, and 96%, 3 min each). This process was used for all samples, except those where the Lab 158 probe was used. Sample slides probed with Lab 158 were subjected to an additional step with 50 ?l of lysozyme (1mg/mL in 100mM Tris-HCl, pH8.0) at 37?C for 15 min prior to being submerged in the ethanol solutions. A probe/hybridization buffer mixture (5 ?l of a 50ngstock of probe plus 45 l of hybridization buffer) was applied to the surface of each well. Hybridisations were performed for 4 hour in an ISO20 oven (Grant Boekel). Slides were stored in the dark at 4?C (for a maximum of 3 days) until cells were counted. Slides were enumerated using a Nikon E400 Eclipse microscope fitted with an EPI-fluorescence attachment, 15 randomized views were counted for each sample.
3. Plasma propionate
Test Request 17-01033
Test Request 17-00782