Incoming Preclinical Laboratory Test Requests

Contract Laboratory has received the following Preclinical Laboratory Test Requests which need to be fulfilled! These Laboratory Test Requests are received from a variety of sources ranging from start-up companies to large, multinational Fortune 500 corporations, international organizations, well-respected universities and government agencies that are actively seeking Independent, Third-Party Preclinical Laboratories to perform their Preclinical Testing, Analysis, Assays, Product Development, Scientific Research Experiments, Inspections, Certifications, and Engineering Projects. If you are a Preclinical laboratory that would like more information on these Preclinical projects, please visit our registration page or call toll us free 1-855-377-6821.

Below are our 50 most recent Preclinical laboratory test requests. Please log in to see more.

17-01450

Preclinical

Laboratory consultant needed to help determine budgetary needs for outfitting new preclinical in vivo laboratory

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17-01360

Preclinical

FDA GMP pharmaceutical preclinical Contract Research Organization CRO needed to for drug inhibition study againstthe replication of the HSV-1 (cold sore) virus by antagonizing arginine in tissue culture. We have a description for tests conducted.

Closed

17-01300

Preclinical

Small molecule therapuetic company needs pharmaceutical preclinical laboratory for low throughput testing the potency of novel compounds to inhibit DGAT2 (Diacylglycerol O-Acyltransferase 2)

Closed

17-01225

Preclinical

Pharmaceutical preclinical Contract Research Organization needed for in-vitro, antimicrobial, kill rate study in an ophthalmic suspension.

Submit Response

17-01179

Preclinical

University Researcher needs preclinical laboratory for in vivo pharmacokinetic /pharmacodynamic PK/PD studies of acrylic based, antihypertensive transdermal therapeutic drug system using rats as model animal.

Closed

17-01125

Preclinical

Preclinical laboratory needed for method development of an immunofluorescence method to be used for nuclear beta catenin and applied to preclinical studies with human cancer tissue and to clinical trial specimens.

Due to nature of drug action, method must be specific for detection of nuclear, and not cytosolic, beta catenin. Method will require confocal microscope. We have the antibody for nuclear beta catenin available commercially.

Closed

17-01120

Preclinical

Preclinical Contract Research Organization CRO needed for Non-GLP , in-vivo anti-pyretic testing of a powdered based analgesic drug. Company would like to consult with the CRO on the experimental design. It's first option is in rats, but they may consider other animal species.

Closed

17-00896

Preclinical

FDA cGMP preclinical Contract Research Organization CRO needed for in vitro and in vivo anti-ulcer activity study of an oral solid dosage pharmaceutical drug product.

Closed

17-00803

Preclinical

Preclinical Contract Research Organization CRO needed for an in vivo osteoinductivity study of a biologic product in an athymic rodent model. Endotoxin, residual calcium, and residual moisture analysis also needed.

Closed

17-00782

Preclinical

Pharmaceutical Contract Research Organization (CRO) needed for preclinical study of efficacy of antimicrobial peptides against corona virus causing Middle Eastern Respiratory Disease including Anti-MERS-CoV assays of the putative AMP as well as cell viability assay.

Closed

17-00780

Preclinical

Veterinary Medicine preclinical opthalmology contract research organization (CRO) needed for an in vivo study of a drug product for a veterinary ophthalmology resident research project. Client is interested in administering the medication q8 hours to >10 healthy adult cats for 12 weeks.

Closed

17-00762

Preclinical

Clinical research laboratory needed for preclinical studies of the effect of a novel molecule in treating the delay in process of myelination. Study to include toxicology, immunology, as well as hematological studies relating to the process of coagulation and fibrinolysis.

Closed

17-00748

Preclinical

FDA / GLP certified and AAALAC registered medical device Contract Research Organization CRO needed for preclinical in vivo thrombogenicity study of implantable cardiovascular catheter

Closed

17-00659

Preclinical

Veterinary medicine laboratory needed for an in vivo preclinical ophthalmology study for efficacy of an eye drop in treating FHV-1 in cats.

Closed

17-00657

Preclinical

Oncology Preclinical Contract Research Organizations CRO needed for in vivo studies of primary or metastatic hepatic / liver cancer using VX2 rabbit and/or Walker 256 rat/mouse orthotopic models. CRO must allow drug payload to be delivered by an external magnetic set up, steered by an MD/bioengineering member of our team.

Closed

17-00606

Preclinical

Contract Research Oganization CRO needed for preclinical and clinical studies.

Closed

17-00589

Preclinical

Preclinical toxicology contract research organization needed for oral drug formulation using a excipient polymer.

Closed

17-00565

Preclinical

Preclinical BSL II contract research organization (CRO) needed for in vivo studies requiring injection of a vector into rat thalamus. Stereotaxic surgery after 21 days by harvest of thalamus and immunohistochemistry performed.

Closed

17-00560

Preclinical

Preclinical Contract Research Organization CRO needed for pharmaceutical in vivo studies involving mice breeding and genetics phenotype testing before and after insult.

Closed

17-00526

Preclinical

Preclinical Contract Research Organization neededed for Influenza vaccination efficacy study in a specific strain of KO mice. Vaccination followed by challenge with live virus. Plasma should be collected before vaccination and at 4 weeks. This should be followed by challenge with the Influenza virus and two weeks of survival curve .Vaccination would be delivered IM and infection delivered intranasally as in humans.

Closed

17-00525

Preclinical

LONG-TERM TESTING FDA GLP hematology laboratory needed for preclinical in vivo blood testing such as CBC/Chem panels, aTTP and TP testing from a variety of species. Samples need to be processed within 24 hours.

Closed

17-00515

Preclinical

Preclinical laboratory needed for toxicology, pharmacokinetic (PK), active ingredient (API), and side effect studies of a weight loss supplement.

Closed

17-00498

Preclinical

Pharma needs preclinical Contract Research Organization CRO for biological, small molecule (viral) in vivo studies of HBV and HCV infections

Closed

17-00382

Preclinical

Certified clinical research laboratory needed for efficacy testing of an anti-aging skin care product with 30 human subjects.

Closed

17-00379

Preclinical

URGENT TESTING FDA GMP Medical device preclinical laboratory needed for product safety and toxicity studies of a plastic dental aligner. Risk Assessment in regards to human exposure (oral, dermal, inhalation) is requested for a dental aligner and support-removal media. The dental plastic aligner is thermoformed onto a 3D printed mold that was previously soaked in our support-removal media.

Closed

17-00371

Preclinical

Preclinical pharmaceutical CRO needed for a pharmacokinetic study and pK analysis in human plasma.

Closed

17-00347

Preclinical

Medical Device preclinical contract research organization CRO needed for insulin characterization with or without infusion through medical device: (1) High molecular weight proteins (insulin aggregates), (2) Preservative content (m-cresol), (3) Impurities, (4) Bioidentity (blood glucose response in rabbits), (5) Zinc content and (6) insulin recovery.

Closed

17-00278

Preclinical

FDA Preclinical laboratory Contract Research Organization CRO needed for in vivo (canine) toxicology and pharmacokinetics / pharmacodynamics (PK/PD) testing of cannabis.

Closed

17-00261

Preclinical

Preclinical laboratory needed for bioactive elucidation and characterization of natural bioactive compounds with validation studies by in vitro, ex vivo and in vivo models.

Closed

17-00184

Preclinical

Pharmaceutical Preclinical Contract Research Organization needed for an in vivo primary sclerosing cholangitis (PSC) study to test a compound in an MDR -/- mouse model to reduce hepatic and biliary damage.

Closed

17-00088

Preclinical

Pharmaceutical preclinical contract research organization needed for in vivo intranasal drug delivery to rats.

Closed

17-00065

Preclinical

Pharmaceutical Preclinical Contract Research Organization needed for Non-GLP in vivo osteomyelitis study.

Closed

17-00064

Preclinical

Pharmaceutical Preclinical Contract Research Organization needed for non-GLP in vivo sepsis study.

Closed

17-00013

Preclinical

FDA GLP medical device preclinical laboratory needed for product safety testing of biodegradable implant for biocompatibility and cytotoxicity according to ISO 10993-5:2016 standards.

Closed

16-02454

Preclinical

FDA GMP, ISO Preclinical Laboratory needed for essential toxicological tests to authorize a new inhalation pharmaceutical product in inhalation pharmaceutical form

Closed

16-02405

Preclinical

FDA GLP Preclinical Laboratory needed for PCR viral testing of two regenerative drug products and raw materials using Pharmacopeia methods:
1. HIV (anti-HIV (I/II),
2. Human T-Lymphotropic virus I and II
3. Cytomegalovirus
4. Epstein-Bar virus
5. Hepatitis C
6. HBV (HBsAg & anti-HBC)

In order to stay in line with the pharmacopeia guidelines, we would like to perform detection of the former viruses on our products with the PCR method.

Closed

16-02361

Preclinical

FDA GMP medical device laboratory needed for preclinical product safety testing: biocompatibility (10993) sensitization, cytotoxicity, irritation and and electrical(60601) testing for class II medical device with focus on FDA application. We need GPMS sensitization, cytotoxicity, muscosal irritation tests conducted. For 60601, IEC 60601-1-2, IEC 60601-1-6, IEC 60601-1 reports are needed.

Closed

16-02253

Preclinical

FDA GLP Preclinical Pharmaceutical Contract Research Organization CRO needed for ICH and FDA GLP in vivo toxicology study testing with the intravenous administration of pharmaceutical agent in canines

Closed

16-02222

Preclinical

Preclinical Laboratory needed for biomechanical testing of Biologic implantables to be used as replacement tissue. Tests needed for mechanical properties such as elasticity, stress relaxation curve, (visoelasticity) yeald, tensile properties to failure point,

Closed

16-02220

Preclinical

Pharmaceutical Contract Research Organization needed for oncology preclinical study of a therapeutic nanoparticle drug delivery systemin Breast cancer mice (HER2 positive)

Closed

16-02063

Preclinical

Pharmaceutical preclinical laboratory needed for in vitro potency testing of COX 1-2 inhibitors

Closed

16-02027

Preclinical

Preclinical Bioanalytical laboratory needed for biological medical device testing: FGF2 and glycosaminoglycans content in small intestine submucosa medical device

Closed

16-01973

Preclinical

Large pharma looking for preclinical laboratory for functional testing to investigate the lack of effect of drug compounds on the cardiac Na-H+ antiporter (profiling).

Closed

16-01937

Preclinical

Preclinical laboratory needed for performing a number of in vitro studies using stromal vascular fraction (SVF) cells.These studies involve labeling of SVF cells with magnetic microparticles and superparamagnetic iron oxide nanoparticles (SPION).

We want to measure the following parameters:

1-Assess cell viability, self -renewal capacity and proliferation capacity. of SVF cells exposed to SPION.
2-Confirm the intracellular uptake of SPION by SVF cells using one or more of the available techniques to determine intracellular iron or SPION content per cell (colorimetric assays: Prussian blue assay, Ferrozine assay; ICP-MS; ferromagnetic resonance; magnetophoresis; MACS).
3- Assess the ability of cells to retain the label throughout several cell divisions (dilution effect).

I will be happy to share any additional information with you in relation to the aforementioned techniques that will be required to perform this set of experiments.

I would appreciate your response ASAP including a quote and available earliest start date for these studies.

You can reach me at your earliest convenience to my cell phone (Cell:+1-630-362-5835), via email: pablogurman@gmail.com, or
Skype: pablogurman

Looking forward to hear from you soon.

Many thanks in advance.

Best regards,

Pablo Gurman, MD
Director
Gur &Gor LLC

Closed

16-01627

Preclinical

Very Experienced, FDA certified Preclinical Contract Research Organization needed for in vivo preclinical studies for 2 phase subset of FDA biocompatibility testing of eye implants in rabbits (eye implants intended to be used for cataract surgery in human). The program includes: - intramuscular or subcutaneous implantation test for 4 weeks - 6 test and 6 control rabbit eyes minimum 6 test months We would need the full set of services including preparation of the detailed study plan according to the ISO standards (ISO 11979-5), performing testing in animals and preparation of the final study plan including statistics.Please specify preliminary pricing offer for the services?

Closed

16-01606

Preclinical

South America Preclinical Contract Research Organization CRO needed for preclinical study of androgenetic alopecia in animal model..

Closed

16-01604

Preclinical

FDA GLP Europe preclinical contract research organization needed for GLP preclinical trial of biodegradable medical device .Animal trial with large animals (mini-Yucattan pigs)

Closed

16-01570

Preclinical

Preclinical Contract Research Organization needed for analysisof serum for two metabolites: Rodent serum sample analysis for ethanol concentration as well as nicotine/cotinine levels. Our current study requires analysis of approximately 450 samples for each of the two metabolites.

Closed

16-01535

Preclinical

Preclinical Contract Research Organization CRO needed for pharmaceutical tests to determine the permeability and absorption mechanisms of a drug using the CACO-2 cell line. Please let me know the cost and time-frame associated with this testing .

Closed

16-01374

Preclinical

Pharmaceutical Preclinical Contract Research Organization CRO needed for preclinical Testing the influence of pharmacological substances on the expression of checkpoint molecules in vitro.

Closed

16-01249

Preclinical

Preclinical laboratory needed for gene enhanced cell therapy toxicology study in immunocompromised rats, cannulated jugular vein injection of gene enhanced cell therapy product. Standard 8 week toxicology study in 20 athmyic nude rats
-Deadline for report is November, require start date of mid-august

Closed

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