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Preclinical Laboratory Test Requests

Contract Laboratory has received the following incoming Laboratory Test Requests which need to be fulfilled! These Laboratory Test Requests are received from a variety of sources ranging from start-up companies to large, multinational Fortune 500 corporations, international organizations, well-respected universities and government agencies that are actively seeking Independent, Third-Party Preclinical Laboratories to perform their Preclinical Testing, Analysis, Assays, Product Development, Scientific Research Experiments, Inspections, Certifications, and Engineering Projects. If you are a Preclinical laboratory that would like more information on these Preclinical projects, please visit Register Laboratories or call toll free 1-855-377-6821.

16-02253

Pharmaceuticals and Biopharmaceuticals

FDA GLP Preclinical Pharmaceutical Contract Research Organization CRO needed for ICH and FDA GLP in-vivo toxicology study testing with the intravenous administration of pharmaceutical agent in canines

Laboratory Needed

16-02222

Biotechnology

Preclinical Laboratory needed for biomechanical testing of Biologic implantables to be used as replacement tissue. Tests needed for mechanical properties such as elasticity, stress relaxation curve, (visoelasticity) yeald, tensile properties to failure point,

Laboratory Needed

16-02220

Pharmaceuticals and Biopharmaceuticals

Pharmaceutical Contract Research Organization needed for oncology preclinical study of a therapeutic nanoparticle drug delivery systemin Breast cancer mice (HER2 positive)

Closed

16-02063

Pharmaceuticals and Biopharmaceuticals

Pharmaceutical preclinical laboratory needed for in vitro potency testing of COX 1-2 inhibitors

Laboratory Needed

16-02027

Medical Devices

Preclinical Bioanalytical laboratory needed for biological medical device testing: FGF2 and glycosaminoglycans content in small intestine submucosa medical device

Laboratory Needed

16-01973

Pharmaceuticals and Biopharmaceuticals

Large pharma looking for preclinical laboratory for functional testing to investigate the lack of effect of drug compounds on the cardiac Na-H+ antiporter (profiling).

Laboratory Needed

16-01937

Biotechnology

Preclinical laboratory needed for performing a number of in vitro studies using stromal vascular fraction (SVF) cells.These studies involve labeling of SVF cells with magnetic microparticles and superparamagnetic iron oxide nanoparticles (SPION). We want to measure the following parameters: 1-Assess cell viability, self -renewal capacity and proliferation capacity. of SVF cells exposed to SPION. 2-Confirm the intracellular uptake of SPI ...

Closed

16-01627

Medical Devices

Very Experienced, FDA certified Preclinical Contract Research Organization needed for in vivo preclinical studies for 2 phase subset of FDA biocompatibility testing of eye implants in rabbits (eye implants intended to be used for cataract surgery in human). The program includes: - intramuscular or subcutaneous implantation test for 4 weeks - 6 test and 6 control rabbit eyes minimum 6 test months We would need the full set of services including pr ...

Closed

16-01606

Pharmaceuticals and Biopharmaceuticals

South America Preclinical Contract Research Organization CRO needed for preclinical study of androgenetic alopecia in animal model..

Closed

16-01604

Medical Devices

FDA GLP Europe preclinical contract research organization needed for GLP preclinical trial of biodegradable medical device .Animal trial with large animals (mini-Yucattan pigs)

Closed

16-01570

Pharmaceuticals and Biopharmaceuticals

Preclinical Contract Research Organization needed for analysisof serum for two metabolites: Rodent serum sample analysis for ethanol concentration as well as nicotine/cotinine levels. Our current study requires analysis of approximately 450 samples for each of the two metabolites.

Laboratory Needed

16-01535

Pharmaceuticals and Biopharmaceuticals

Preclinical Contract Research Organization CRO needed for pharmaceutical tests to determine the permeability and absorption mechanisms of a drug using the CACO-2 cell line. Please let me know the cost and time-frame associated with this testing .

Closed

16-01374

Pharmaceuticals and Biopharmaceuticals

Pharmaceutical Preclinical Contract Research Organization CRO needed for preclinical Testing the influence of pharmacological substances on the expression of checkpoint molecules in vitro.

Closed

16-01249

Healthcare and Medical

Preclinical laboratory needed for gene enhanced cell therapy toxicology study in immunocompromised rats, cannulated jugular vein injection of gene enhanced cell therapy product. Standard 8 week toxicology study in 20 athmyic nude rats -Deadline for report is November, require start date of mid-august

Closed

16-01158

Animal Science and Veterinary Medicine

Veterinary Medicine Laboratory needed to assess the preclinical efficacy of an investigational anthelmintic drug in a rodent model infected with intestinal worms.

Closed

16-01155

Pharmaceuticals and Biopharmaceuticals

Preclinical Contract Research Organization needed for multiplex assays or proteomic studies for toxicity study on therapeutic treatment for Muscular Dystrophy. The study involves determination of kidney and liver toxicity in mouse samples (i.e. serum and urine). Our aim is to determine whether we can detect kidney and liver toxicity biomarkers in mice which have been chronically treated with these oligos at various doses. If we can successfully ...

Closed

16-01140

Pharmaceuticals and Biopharmaceuticals

Preclinical Contract Research Organization needed for alloxan, STZ, STZ + Nicotinamide diabetic nephropathy models. oxidative stress markers, blood and urine analysis, immunohistochem, Rt- PCR

Closed

16-01099

Pharmaceuticals and Biopharmaceuticals

LONG-TERM: Preclinical CRO Immunology/Histology Laboratory needed for Non-GLP histological processing from buffered formalin fixed tissues (human and animal, size 6 mm diameter, approx. 40 um thick) into H&E stained slides (at 3 different levels) and about 10 FFPE unstained slides for further subsequent immunohistochemistry,

Laboratory Needed

16-01069

Pharmaceuticals and Biopharmaceuticals

USFDA GLP preclinical contract research organization laboratory needed for method development Need to develop bio assay for antibiotics

Closed

16-01057

Pharmaceuticals and Biopharmaceuticals

LONG-TERM: Preclinical CRO Immunology/Histolgoy Laboratory needed for Non-GLP histological processing from buffered formalin fixed tissues (human and animal, size 6 mm diameter, approx. 40 um thick) into H&E stained slides (at 3 different levels) and about 10 FFPE unstained slides for further subsequent immunohistochemistry,

Closed

16-00898

Pharmaceuticals and Biopharmaceuticals

Preclinical contract research organization needed in vivo testing on a human intravenous anti-neoplastic medication.

Closed

16-00885

Pharmaceuticals and Biopharmaceuticals

US preclinical Contract Research Organization CRO needed for efficacy study in AAV ?-synuclein transgenic Rat and/or Mouse model against Parkinson?s disease TA is recombinant protein and dosing route is IV. frequency was not decided so they are thinking daily in preclinical studies.

Closed

16-00853

Medical Devices and In-Vitro Diagnostics

FDA GMP preclinical laboratory needed for ISO 10993 Biocompatibility testing for a Class II Hemodialysis Catheter

Closed

16-00809

Pharmaceuticals and Biopharmaceuticals

Preclinical Contract Research Organization needed for alloxan, STZ, STZ + Nicotinamide diabetic nephropathy models. oxidative stress markers, blood and urine analysis, immunohistochem, Rt- PCR

Closed

16-00806

Pharmaceuticals and Biopharmaceuticals

Preclinical Contract Research Organization CRO needed for preclinical baby infant formula testing: AOAC Protein Efficiency Ratio (Rat Bioassay) testing - official method 960.48. Testing needed to comply to demonstrate Quality Factor Requirements Under 21 CFR 106.96(i)

Closed

16-00791

Pharmaceuticals and Biopharmaceuticals

University Researcher / Start-up Pharma needs USA Preclinical Contract Research Organizations CRO's needed for immunohistochemistry proof-of-concept studies (in vivo and in vitro experiments) . Central USA preferred.

Closed

16-00724

Nutraceuticals and Dietary Supplements

Preclinical Contract Research Organization CRO needed for preclinical trial for specialized health supplement product. The objective is to measure the impact of product on the blood lactate level of ill test subjects, possibly rats. The type of illness can vary but we are especially interested in cancer. Please get back to me with pertinent information including pricing and timeline. For your information, we are located in British Columbia, ...

Closed

16-00545

Preclinical Bioanalytical Laboratory needed for protein analysis by C2C12 assay for osteoinductivity. The material being tested is a bone morphogenetic protein compound. Two preclinical studies.

Closed

16-00304

Gastroenterology Preclinical Product Safety Contract Research Organization (CRO) needed for weight loss study with capsule inserted in the stomachs of 6 genetically obese mice and then have mice observed for weight loss.

Laboratory Needed

16-00238

USA or Europe Pharmaceutical preclinical CRO contract research organization needed for efficacy testing of our new dental combination anesthetic medicinal product vs. the reference product in the following in-vivo standard animal models: guinea pig intradermal wheal assay; mouse or rat tail-flick test (at that conduction and infiltration anesthesia) and also optionally in ''mouse sciatic nerve blockade model''. Please send us a corresponding bud ...

Laboratory Needed

16-00183

India Pharmaceutical Science Researcher needs Pharmacology Contract Research Organization for Pharmacology Study Experiments: AIM AND OBJECTIVES OF THE SCIENTIFIC REASERCH WORK The study has been designed to serve the following objectives: 1. To explore the critical role of selected antioxidants, minerals and vitamins on gastro protection by using various antiulcer screening models and biochemical parameters in rats. 2. To compare the effec ...

Laboratory Needed

16-00103

Unviersity Researcher needs Preclinical laboratory forTesting compounds topically using the toluene diisocyanate acute contact dermatisis mouse model. Ability to measure secondary endpoints such as lymphopenia

Laboratory Needed

16-00071

Preclinical Laboratory needed for in-vivo gastroenterology study to get a first estimation of the likelihood that a gastroenterology physical barrier might become twisted or entangled in some fashion that it could cause harm to the animal and my inference to any future human trials. Another objective is to identify any undesirable elements associated with food waste that has not had its nutrients removed in a normal manner.Need to have specially ...

Laboratory Needed

16-00066

Pharmaceutical Preclinical Laboratory needed for four different in-vitro and in-vivo research experiment research studies: 1) In vivo-Balb/c mice CLP model- First experiment of about 100 animals, readout will be survival. Possibly additional experiments in this model where additional outcomes will be desired: e.g. cytokines, T cell distribution, body temperature, apoptosis. 2) Kinetics-Determine the residence time of our drug on its target (tra ...

Laboratory Needed

16-00045

Pharmaceutical Contract Research Organization CRO needed for FDA GLP preclinical In vitro equilibrium binding studies for one the product as per US FDA guidances.

Laboratory Needed

16-00003

FDA GMP Preclinical Laborator needed for Bio equivalence study and report of solid, semi solid and nasal spray of general and potent drug category for ANDA filing to US FDA. We need the cost (average) and time frame.

Laboratory Needed

15-02078

USA pharmaceutical preclinical contract research organization needed for study using sternum infection model. The model will allow us to test the efficacy of product intended to prevent surgical site infections. Must also have in-house microbiology unit.

Closed

15-02067

PhD scholar needs India preclinical contract research organization for in vivo study on and I gastroretentive formulation.

Closed

15-02046

Preclinical Laboratory needed for Biocompatibility Study for implant material SS 316L as per ISO 10993 , Biological evaluation of medical devices

Closed

15-02015

Preclinical Contract Research Organization needed for preclinical study of test compand that prevents vascular permeability. Histamine skin prick or intradermal injection in rat.

Closed

15-01863

Europe preclinical contract research organization laboratory needed for biomarker study for the diagnosis and treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome/Systemic Exertion Intolerance Disease using mitochondrial dysfunction as the biological marker for diagnosis. We are looking for a laboratory with an international presence and broad spectrum of tests available to adopt a new diagnostic protocol for ATP profiling .

Closed

15-01851

Europe FDA GLP Preclinical Laboratory needed for Development and qualification for disulfide scrambling and determination of free SH, ATM release

Closed

15-01846

Preclinical Laboratory needed for Research Study with FITC-induced Delayed-Type Hypersensitivity model in C57/B6 mice

Closed

15-01743

Preclinical laboratory needed for study to determine if antiviral product induces f immune response in cell culture. Would like to test for cytokine expression in cell culture

Closed

15-01708

Ireland University Researcher needed for preclinical studies efficacy and cytotoxicity testing on Platinum(IV) drug anti-cancer agents. I am already working on identifying the effectiveness of these drugs e cytotoxicity studies on different cell lines

Closed

15-01682

Germany or Europe Contract Research Organization needed for preclinical study to Test of novel immune stimulatory compounds in a mouse cancer model. Compounds are provided, mouse lab needed.

Closed

15-01670

Europe, Germany or Poland Contract Research Organization Preclinical Laboratory needed for preclinical study on drug suppositories : Local (rectal) tolerance testing according the Note for guidance on non-clinical local tolerance testing of medicine (rabbit, dog)

Closed

15-01644

Preclinical Contract Research Organization needed for OECD preclinical Acute inhalation toxicity OECD 403 nose-only exposure (vapours)

Closed

15-01638

Pharmaceutical Preclinical Contract Research Organization of compound to reduce vascular inflammation need to shown it attenuates Hist-driven vascular peremeability.. Histamine challenge testing in rat and dog

Closed

15-01550

USA Preclinical Contract Research Organization needed for Bioavailability and Bioequivalance Preclinical Studies of UDCA ursodeoxycholic acid. We need BA/BE studies for our product approval process.

Closed

15-01540

USA preclinical Contract Research Organization needed for astma and COPD preclinical research study using guinea pig smoke exposure model with 32 male Dunkin-Hartley Guinea pigs will be randomly assigned to four equal groups with n = 7 per group Thirty-two (32) male Dunkin-Hartley guinea pigs weighing 350 to 450 g

Closed

15-01539

USA preclinical Contract Research Organization needed for preclinical research study to evaluate VNS induced arrest of early- and late-response bronchoconstriction in an ovalbuminsensitized guinea pig asthma model. Thirty-two (32) male Dunkin-Hartley guinea pigs weighing 350 to 450 g will be obtained from National Laboratory Animal Center

Closed

15-01538

USA Preclinical Contract Research Organization needed for preclinical study to characterize how relative timing of SPG stimulation and drug bolus affects BBB permeability, we will employ the craniotomy procedure described by Yarnitsky et al (16) and stimulate the SPG using percutaneous leads in femal nude rats

Closed

15-01523

Large Pharma needs preclinical contract research organization CRO for preclinical study to test of effect of chemical compounds for the platelet aggregation

Closed

15-01428

FDA GLP preclinical contract research organization CRO needed for GLP non-clinical pharmcodynamic tests for on acute inflammation, chronic inflammation and nociceptive activity with one of our gel products containing a combination of piroxicam0.5%/cyclobenzaprine 0.5%/lidocaine2% gel (Sindolor gel) vs piroxicam gel, cyclobenzaprine gel and lidocaine gel alone and placebo.

Closed

15-01355

USA Pharmaceutical Contract Research Organization needed for preclinical studies: Transepidermal Moisture Loss, irritation testing(dermal, vaginal), sensitization testing, comedogenicity, scar studies, and Biofilm evaluation.

Closed

15-01353

Pharmaceutical Preclinical laboratory needed for Large Molecule Bioanalysis Studies ( PK and Immunogenicity)

Closed

15-01267

Pharmaceutical Preclinical Contract Research Organizations needed with vivo model to test the activity of an anti-infective compound against biofilm

Closed

15-01230

Preclinical Medical Device Laboratory needed for Medical Devices Vibration testing, Medical Devices Impact, Medical Devices Electromagnetic Compatability Testing EMC Testing

Closed

15-01181

USA Preclinical Contract Research Organization needed for Chemical analysis of a slow release formulation of chlorhexidine gluconate to evaluate the release profile following use in an animal model.

Closed

15-01113

University researcher needs India preclinical laboratory for invitro biocompatibility testing of few specimens with silver nanoparticles

Closed

15-01079

United States or Europe FDA GLP Compliant Preclinical Immunology COntract Research Organization CRO needed for Inflammation Model In Vitro Studies to Test Effect of Reactive Oxygen Species Product on Epithelial Cells. Specifically, NF-kB Translocation into the Nucleus, Translocation of NRF2 Transcription Factor, Efficacy of Glutathione Peroxidase and Superoxide Dismutase, Protective Effect on Damaged Cells, and Reception of Cachexin in Normal an ...

Closed

15-01055

Preclinical Contract Research Organization needed for preclinical study done on the levels of EDTA in the blood stream after oral administration of our microencapsulated EDTA compared to non encapsulated EDTA. This would show us how effective our microencapsulation process is on protecting EDTA from stomach acids and its effectiveness on absorption.

Closed

15-01053

USA / CANADA Preclinical Virology Laboratory needed for initial proof of concept pre-clinical testing of our compound in regards to anti-viral activity against HSV-2, HSV-1 (genital herpes) and HPV (human papillomavirus). Example of the testing system: cell-based assay demonstrating ability of the compound to act as "entry inhibitor".

Closed

15-00999

FDA and NIH compatible California preclinical laboratory needed for Preclinical testing of an antimicrobial compound.

Closed

15-00948

URGENT Biotech company needs Preclinical Contract Research Organization needed for small mouse feeding/immunization study 32 individually housed mice that would be fed corn meal wafers with the antigen of interest at several intervals and collection of serum and fecal samples over roughly two months. The samples would be analyzed by us. The study would take place in the first half of 2017 after the preparation of new maize lines. At this point ...

Closed

15-00936

US Preclinical Contract Research Organization CRO needed for preclinical drug development to evaluate the effects of experimental topical formulation on healing of HSV 1 skin lesions using mouse flank scarification infection model

Closed

15-00863

Preclinical Contract Research Organization CRO needed with proven experience in Ischemia/Reperfusion Acute Kidney Injury (I/R AKI) preclinical models in mouse and/or rats.

Closed

15-00827

Preclinical Contract Research Organization CRO needed for Toxicity testing and Bio-distribution studies for the assessment of the potential effects of a Natural Killer (NK) expanded cell product in NSG or NOD/SCID mice. Biodistribution of the cells in various organs and tissues. Test for treatment-related adverse reactions. Test for Human DNA in several mouse tissues

Closed

15-00788

INDIA FDA GLP CONTRACT RESEARCH ORGANIZATION PRECLINICAL LABORATORY NEEDED FOR AN FDA GLP COMPLIANT WOUND HEALING STUDY: A FULL THICKNESS WOUND HEALING STUDY FOR 30 DAYS IN A SWINE MODEL

Closed

15-00782

Preclinical COntract Research Organization needed for vascular/tissue Calcification testing in vitro using human vascular smooth muscle(HVSM) monolayers and rat vsmc to evaluate the performance of several agents and their combinations in vitro using human smooth muscle cells (HVSM) and rat vascular smooth muscle cells or aortic rings. Test methods require staining and calorimetric measurements. We will provide the details of the test methods. ...

Closed

15-00767

Preclinical Laboratory needed for scientific experiments - patch clamp experiments for GABA positive modulator study (GABA PAM assay). And is it possible in neuron (slice or cultured neuron)

Closed

15-00730

BSL-3, FDA GLP Europe and Eastern Europe preclinical contract research organization needed for GLP Hapatitis C vaccine candidate testing for , pre-clinical research program

Closed

15-00727

India Preclinical Laboratory needed for in vitro studies for anticancer agentMTT Assay, in vitro studies for anticancer agentcolony formation assay, wound assay etc

Closed

15-00442

Pharmaceutical University Researcher needs preclinical contract research organization (CRO ) laboratory for PK Study: pharmacokinetic study of levetiracetam usinh HPLC column: chromosil C18 column (250 X 4.6 mm, 5u)mobile phase: Acetonitrile, phosphate buffer, waterflow rate: 0.9 ml/minrum time: 5 mindetection wavelength: 205 nm

Closed

15-00404

Preclinical Contract Research Organization needed for Metabolism Studies in Pigs, Poultry, Dairy Cows and Fish

Closed

15-00403

Preclinical contract research organization needed for In vitro tissue model studies

Closed

15-00387

USA Bioanalytical Preclinical Laboratory needed for bioanalysis: cytokine testing from micro-dialysis fluid for company completing research on burn scars and testing for certain cytokines levels in micro-dialysis fluid from the scar areas. Approx 72-108 samples. Cytokines to be analyzed include TGF-beta, TGF-B1, Decorin, TNF-alpha, IL-4,6,10, LSP-1, CTGF and VEGF

Closed

15-00335

Preclinical Laboratory needed for cancer cell line testing: Cytotoxicity and LDH release (1) We would like to know the effect of organic compound on at least two different normal human cell lines (MTT assay) (2) We also need cellular toxicity data of compounds for LDH release at one or two doses (IC50 and 2x IC50) as function of time in any cancer cell line.

Closed

15-00313

Preclinical Contract Research Organization need to Construct 2 plasmids, transfect primary cells in vitro, measure telomere lengths using flow cytometry.

Closed

15-00234

Dental contract research organization cro needed for FDA GLP preclinical study: periodontal disease using bacteriophage-based therapy in ferret and murine

Closed

15-00202

USA Preclinical Contract Research Organization needed for In vitro testing using human liver cell/cell lines to test some active candidates to detect certain protein (including enzymes and transcription factors' ) expression (protein or its gene) and/or activity.

Closed

15-00149

USA preclinical contract research organization needed for nonclinical hairgrowth model study to assess the ability of a pharmaceutical product to reduce hair growth.

Closed

15-00116

Preclinical Laboratory needed for Preclinical BioEquivalence/Bioavailability BE/BA Studies, Phase I clinical studies).

Closed

15-00106

University Medial Researcher needs Saudi Arabia Preclinical laboratory needed for Insulin and Hb1ac testing Superoxide dismutase(cu/zn) catalase, glutathion peroxidase, Total antioxidant capacity, Thiamine &thiamine pyrophosphate, Vitamin C&E estimation kits, Cu&Zinc estimation kits in mice,

Closed

15-00086

Preclinical COntract Research Organization needed for preclinical studies and biocompatiability testing of medical device implant: implantable membrane for breast reconstruction (tissue reinforcement matrix, class III device), to be associated with tissue expanders and breast implants. The membrane is a modification of an already implantable silicone membrane, which is modified on the surface by plasma treatment. We would like to know if p ...

Closed

15-00047

Medical Device Preclinical Contract Research Organization needed for Product Safety Studies: System toxicity (acute) for medical deviceTesting collection system for autologous fat; collecting fat in a container, then immediately reinserting that person's fat back into their body in a different location. ISO 10993 Part 1

Closed

15-00032

Dietary supplement manufacturer needs preclinical laboratory /contract research organization for formulation, pilot runs and stability studies for clinical placebos and tablets, capsules, or powder and bottle them for such Clinical studies. We also have frequent need for products to go through the stability process. Order quantities would range from about 50 bottles to several thousand. We many times, would require placebos as well.

Closed

15-00021

Preclinical Contract Research Organization needed for preclinical cardiology study: Heart-Rate Recovery during extreme endurance exercises

Closed

15-00015

Europe GLP preclinical contract research organization needed for GLP preclinical studies for fixed drug combination: Pharmacodynamic, pharmacokinetic, general toxicity - 3 month duration in one species

Closed

15-00013

Europe or US Preclinical Contract Research Organization needed for preclinical study: pharmacology Testing of experimental compound in mouse model of Graft versus host disease, or mouse model of hematopoietic stem cell transplantation

Closed

15-00008

Preclinical Contract Research Organization needed for Preclinical Toxicology Study: Ototoxicity evaluation of a test article(ear drops agent)administrated bid via implanted catheter connected with middle ear in chincillas or any other animals.

Closed

15-00007

Large Pharma needs Contract Research Organization CRO for in0vivo presclinical study: preclinical testing in the TMEV model Theiler's Murine Encephalomyelitis Virus (TMEV)

Closed

14-01625

Preclinical Contract Research Organization needed for bioanalytical testing: Fatty Acid analysis for blood, serum, cells, and tissue samples from animal models (such as Mouse)

Closed

14-01504

USA ISO Preclinical Laboratory needed for preclinical testing on toothpaste. Tests for development are generally performed to: 1. Develop a toothpaste 2. Routine QC

Closed

14-01486

France Preclinical Contract Research Organization needed to test the anti-cytokine profile of anti-inflammatories in vitro

Closed

14-01485

Preclinical Contract Research Organization needed for Neurology Toxicology Studies: Ototoxicity and protection against ototoxic insults such as antibiotics, cytotoxic drugs, age, noise

Closed

14-01465

Biopharmaceutical company needs pharmaceutical Embryology Preclinical Laboratory needed for embryo implantation research study.

Closed

14-01413

Dental manufacturing company needs preclinical contract research organization for medical device product safety studies including oxicology and biocompatibility studies on medical device of macroporous hydroxyapatite powder (calcium phosphate) used in dentistry, maxillofacial surgery, orthopedics and traumatology in order to replace or substitute the bone tissue. In order to check its biocompatibility we need following tests according to ISO 1099 ...

Closed

14-01344

USA Pre-clinical Contract Research Organization needed for preclinical virology studies: anti-HIV testing in cell-based assay

Closed

14-01338

FDA GMP Preclinical Contract Research Organization needed for FDA GMP preclinical experiments: 1) Exposing human plasma to the test article to modified plasma proteins 2) Investigating the antiviral effect of the modified plasma protein on HIV-1 in vitro. The study protocol should meet the FDA requirements for antiviral drug (proving the concept). I appreciate if you could provide us the list of the required experiments, the timeline, a ...

Closed

14-01326

Pharma needs USA Preclinical Contract Research Organization for Skin Permation Study on 4 Drug Test formulations Number of donor skins- 3 Number of test formulations- 3 (2 test and 1 reference) Number of replicates per formulation-6 Number of samples per diffusion cell- 11(4,8,12,24,32,48,72,96,120,144,and 168 hours)

Closed

14-01321

Pharma needs Preclinical Contract Research Organization CRO for preclinical toxicity study of some injectable drug candidates in rats (4 formulations in total). The samples are polymeric nanoparticles for treating liver cancer

Closed

14-01293

Preclinical Laboratory needed for preclinical studies : Fibrosis model (e.g. bleomycin skin or lung, carbon tetrachloride liver or others) run in rabbit or guinea pig. Dose compound and conduct standard histology. Assess development of fibrosis in tissues and anti-fibrotic effect of compound.

Closed

14-01278

Canada Preclinical Contract Research Organization needed for Drug Discovery Research (Antimicrobial testing and Cytotoxicity testing ) to test 3 compounds in antimicrobial assays and human skin-cell line toxicity screens. Antimicrobial assays should include 2-3 Gram + bacteria, 2-3 Gram - bacteria, and 2-3 fungi. Cytotoxicity screens to be performed on keratinocyte and fibroblast cell line. We require MIC and IC50 determination for each compoun ...

Closed

14-01262

FDA Medical Device Preclinical Laboratory needed for medical lubricant testing for FDA 510k: cytotocity., vaginal irritation and systematic toxicity,maximum sensitization, condom compatablity and All tests needed for personal lubricants including condom compatibility.

Closed

14-01224

Preclinical Contract Research Organization CRO needed for Performance testing in a canine jaw model

Closed

14-01154

East Coast USA GLP Certified Preclinical Contract Research Organization CRO needed for Product Safety Environmental Toxicology Studies: Acute oral LD50 Study, Acute Dermal LD50Study, Acute inhalation LC50 Study, eye irritation study, skin irrational study, dermal sensitization study

Closed

14-01146

Europe Preclinical Contract Research Organizations needed for topical multifunctional drug study The tests can be performed very quickly, since the drug is applied topically and the effect is immediate due to the specific mode of action.

Closed

14-01124

USA FDA GMP Preclinical Contract Research Organization needed for GMP preclinical vaccine efficacy Study in lactating dairy cows Vaccine to prevent Staph or Strep mastitis Vaccine cows before freshening After parturition, determine antibodies challenge with Strep or Staph in a single teat follow milk, CBCs, etc before and after vaccine and challenge

Closed

14-01115

Preclinical contract research organization needed for USP class VI cytotoxicity testing.

Closed

14-01107

USA or EU Prelinical Contract Research Organization needed for non-GLP preclinical study: Gas exchange performance testing per ISO 7199 on gas exchange devices (non GLP)

Closed

14-01086

USA preclinical laboratory needed for DGR and IATA testng to IATA Requirements for UN2810, Toxic, liquids, organic, n.o.s. Oral LD50, Dermal LD50, Inhalation LD50 (mist), for Rats

Closed

14-01068

USA Preclinical Laboratory needed for Pre-clinical Pharmacology Study Investigating receptor occupancy and affinity for 3 - 4 compounds at 3 - 4 dosing levels.

Closed

14-00985

Medical Device Manufacturer needs preclinical contract research organization for ISO Biological Evaluation of "Pressure Monitoring Kits". Tests to be perform as per- ISO 10993(External communicating device/Blood path, indirect/Limited duration) -Cytotoxicity -Sensitization -Irritation or Intracutaneous reactivity -Acute systemic toxicity -Pyrogenicity -Hemocompatibility Pls address:

Closed

14-00984

University Medical School Researcher needs preclinical contract research organization for blood glucose drug comparison study of preexisting drug that can reduce blood glucose and potentially be used as a diabetes drug. We would like to compare the HbA1C between placebo and treated group.

Closed

14-00951

Pharmaceutical company, presently developing transdermal dosage form (an ointment) needs FDA GMP preclinical laboratory for FDA GMP validation of in vitro release method using Enhancer cell immersed in modified apparatus 2 (mini paddle apparatus) and latter on transfer of validated method to our facility. We will share more details on your reply.

Closed

14-00906

Internationally Accepted Accredited Labs China, India, Asia or Europe preclinical laboratory needed for Biocompatibility Testing acc. to ISO 10993 ISO 10993-11 Tests for subchronic Toxicity ISO 10993-6 Implantation,

Closed

14-00862

India preclinical laboratory needed for preclinical testing to determine if drug is safe for external use in human beings. The testing of the product is to be done on swine for determination of change in clotting time.

Closed

14-00851

GLP Preclinical Contract Research Organization needed for non-clinical research services. Could be located in NA or India/China. Must be high quality."

Closed

14-00820

California Preclinical Laboratory, Contract Research Organization CRO needed for Preclinical testing, biocompatibility, performance and integrity. Acrylic bone cement and mixiing and delivery system

Closed

14-00758

Preclinical central laboratory needed for antibiotic study clinical patient testing: Protozoa testing for growth inhibition testing using antibiotics (In vitro)

Closed

14-00663

FDA cGMP Preclinical Contract Research Organization CRO needed for FDA cGMP testing: Analytical chemistry services: LC-MS-NMR for structural elucidation of bioactive molecules derived from desert medicinal plants

Closed

14-00661

INdia Preclinical TOxicology COntract Research Organization needed for ocular drug delivery study. no of sample six...six piece rabbit eye is required..drug testing on occular drug delivary

Closed

14-00660

Preclinical Contract Organization (CRO) needed for preclinical testing of antigens, if present in sample of an allogeneic human pharmaceutical Placental Suspension (ph.PS) prepared upon Filatov?s method, which in previous laboratory studies has shown immune reactions against sera of cancer patients. The aim is that your creative team of scientists to initiate a project to design a fair-value proposal that meets the scientific and drug development ...

Closed

14-00521

Preclinical Laboratory needed for pharmacokinetic Testing: pKa determinations and redox potentials for organic compounds

Closed

14-00516

EMAI FDA GLP Contract Research Organization CRO needed for FDA GLP preclinical toxicology and Immunogenicity studies with primates where our products can be evaluated by IV route, administrated daily during 12 weeks and 4 weeks of recovery period. We want evaluated comparatively two products with two level doses and a control group. The number of animals per group would be 3 animals/sex/group. It would be evaluated Hematology/Biochemis ...

Closed

14-00508

Preclinical Contract Research Organization needed for in vivo testing of peptide with AV activity in plaque assays. We are interested in organ on a chip - or similar, low cost, non-animal testing procedures. I know this is new technology. Is there a laboratory that has it available?

Closed

14-00505

USA FDA GLP Contract Research Organization CRO Preclinical Laboratory needed for FDA GLP Preclinical Study: Acrolein (CAS# 107-02-8) - gas phase (heat trap, release) Matrix: Cotton swabs (J&J q tips); cellophane adhesive tape); in tissue (i. epithelial layer, ii. buccal membrane); six different tobacco products (chewing tobacco), organic solvent and DMSO. Benzapyrene (CAS# 50-32-8) ? same matrix as Acroline except for no gas phase (just ...

Closed

14-00502

USA Pharmaceutical Contract Research Organization needed for preclinical study: lung cancer testing dopamine ( via original novel published apparatus system ) - query prevention and treatment effects and statistics or probability of mice acquiring small cell lung cancer( 20% ) vs other lung cancers (80%).

Closed

14-00487

India Preclinical Contract Research Organization CRO needed for Preclinical studies for DHA Oil

Closed

14-00463

North America non-GLP Contract Research Organization CRO needed for non-GLP preclinical studies that can test experimental compounds in the mouse model or unilateral ureteral obstruction"

Closed

14-00368

Preclinical Toxicology Laboratory needed for the eye irritation testing on rabbits using Moxifloxacin HCl, one eye drops and to observe for any irritation for 025hr,0.5hr,1,2,3,6,12,18,24,48 &72 hrs , keeping other eye as a control and scoring if any irritation by giving score from 0-4.

Closed

14-00339

Biopharmaceutical company needs Orthopedic Preclinical Contract Research Organization CRO for preclinical testing studies: animal models for preclinical studies of osteomyelitis

Closed

14-00326

Preclinical Contract Research Organization CRO needed for preclinical studies: Cytotoxicity, Sensitization, Hemocompatibility. .

Closed

14-00278

Orthopedic Contract Research Organization CRO needed for preclinical study: pre-clinical testing involving the placement of an intramuscular implant into the hamstring of athymic rats followed by a histological analysis for bone formation after 30 days.

Closed

14-00128

Egypt or Middle East Preclinical Contract Research Organization needed for Multiple Sclerosis Toxicological Study with novel molecule for treatment of multiple sclerosis for FDA approval

Closed

14-00113

USA Preclinical Contract Research Organization needed for toxicology study. Conduct study involving 4-week exposures to 1 control, 1 positive control, and 3 different (non-volatile) test-chemical diets, using groups of 6 transgenic F344 rats and 6 transgenic B6C3F1 rats. Quantify corresponding rates of mutation in 4 target tissues: liver hepatocytes, kidney (cortical cells and tubular epithelial cells), and bladder epithelial cells. in vivo GL ...

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14-00011

AALAC, FDA, GLP Pharmaceutical Toxicology Preclinical Laboratory needed for FDA GLP Toxicology Studies: Ototoxicity study (GLP) Required test : Ototoxicity evaluation of a test article(ear drops agent)administrated bid for 28 days via implanted catheter connected with middle ear in chincillas or any other animals. (*** exception of guinea pigs)

Closed

13-01666

USA or Asia FDA GMP Preclinical Laboratory needed for preclinical testing: nose filler - strontium hydroxyapatite 1. MTT assay on human epithelial fibroblast 2. in vivo testing on rabbit frontal sinus

Closed

13-01649

Pharmaceutical Preclinical Laboratory needed for preclinical testing: tests three skin treatments to qualify for National Eczema Assn. Seal of Acceptance: 1. Repeated Insult Patch test 2. Cumulative Irritation Test 3. Photo Toxicity Test 4. Stability Test

Closed

13-01623

Africa preclinical laboratory needed for preclinical testing: Medical Research-Nuclear Extracts and Serum samples. There would be need for ice pack

Closed

13-01613

FDA GMP Preclinical Laboratory needed for FDA Preclinical testing. Dental implants to be implanted in non-human primates in the mouth.

Closed

13-01563

USA CRO, Preclinical Laboratory for preclinical pharmaceutical compound testing Non-clinical study in vitro testing. Compounds testing in human macrophage/neutrophil/lymphocytes cell lines cultures for chemokines/cytokines secretions and or gene expressions

Closed

13-01466

FDA GMP North Carolina preclinical CRO, contract research organization needed for FDA preclinical study: ELISA testing for tissue levels of Avastin and Lucentis monoclonal antibodies. 100 samples

Closed

13-01458

OECD GLP Bioaalytical Preclinical Laboratory needed for pharmaceutical preclinical plasma testing: Analysis of , B2M, neopterin, 2'5'-OAS and ADA, biosimilar INF-alfa in blood plasma samples (human and animal samples). Validation according EMA guidelines.

Closed

13-01416

Preclinical Laboratory needed for non-GLP preclinical studies: in vitro testing and in vivo testing (rodents only) cancer, autoimmune, inflammation

Closed

13-01386

FDA GLP Preclinical CRO Contract Research Organization needed for Preclinical GLP Porcine Survivor Study Study needed observing pig survival over 10 days after vaporization/ablation on the bowel serosa. Probably a relatively few number of pigs needed.

Closed

13-01342

NABL India Preciical Laboratory needed for preclinical study: ionophoretic transdermal patch.we want to test the performance of that transdermal patch.

Closed

13-01331

India FDA GMP preclinical laboratory needed for preclinical studies. Ex-Vivo Study (Macrophage uptake studies , MTT and apoptosis assay for cytotoxicity) using FACS analysis of polymers based drug delivery systems for development of oral delivery of proteins/ peptidal drugs. .

Closed

13-01308

Preclinical contract research organization needed for preclinical study with Model of anaphylactic shock in rats

Closed

13-01191

Preclinical Laboratory needed for preclinical studies: sublingual preclinical testing.

Closed

13-01145

Preclinical microbiology laboratory needed for viral testing on cell lines. Cell Line testing includes Viral screening of human mesenchymal stromal cell line that will be administered to patients with stroke for a Master Cell Bank. Viral screens on the cells: HBV, HCV, HIV 1&2, Parvovirus B19, CMV, HHV 6/7/8 and HTLV 1&2?

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13-01122

Toronto Preclinical Laboratory needed for preclinical study testing: Cell Culture Human pulmonary carcinoid cancer cell lines (H727 and H720) will be maintained in RPMI 1640 and supplemented with 10% fetal bovine serum, 100 IU/mL penicillin and 100ug/ml streptomycin, sodium pyruvate, D-glucose, 10mM HEPES. The cell lines will be maintained at 37C in 5% CO2 and 95% air. Cellular Proliferation Cellular proliferation will be assessed with 3-[4 ...

Closed

13-01114

Contract Research Organization, Preclinical Laboratory needed for preclinical study: Animal Model of Pulmonary Arterial Hypertension (PAH) on SD Rat induceted by monocrotaline

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13-01093

Europe Preclinical Laboratory, Contract Research Organization CRO needed for preclinical study of Hepatoprotective effect, model of paracetamol-induced liver damage. Follow-up for one month with full range of observation tests (morphology, histology, biochemistry). One test sample, water solution, parenteral injections. No special storage or handling requirements.

Closed

13-01081

India preclinical laboratory needed for preclinical testing: in vitro testing for anti HBV and HCV property One sample with potential anti viral property of a compound to be tested against HBV and HCV.

Closed

13-01047

USA preclinical laboratory needed for kidney surgical testing. Post kidney removal testing with high reactivity carbon mixture (HRCM, or graphene) in rats.

Closed

13-01043

FDA GMP Preclinical Laboratory Contract Research Organization needed for FDA GMP Preclinical Study: Preclinical Testing of somatropin in hypophysectomised rats

Closed

13-01021

Europe Preclinical Toxicology Laboratory needed for Sensitization Testing , according to 11979-5, applied to intraocular lenses

Closed

13-00980

Preclinical Laboratory Contract Research Organization CRO needed for preclinical study on Ovalbumin induced asthma model for testing novel antibodies

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13-00974

India preclinical contract research organization needed for preclinical study testing: Animal experiment for wound healing

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13-00973

United Kingdom Preclinical Contract Research Organization CRO needed for preclinical study of Transgenic mice (Tg2576) chronic studies -Alzheimer's application

Closed

13-00962

European Union or US Preclinical Laboratory, CRO Contract Research Organization needed for preclinical study with Validated rat bleomycin lung model needed. Compound dosing required.

Closed

13-00851

USA Preclinical CRO contract research organization needed with expertise in various animal models of tissue ischemia, traumatic brain injury and critical limb ischemia.

Closed

13-00800

USA or Europe Preclinical Contract Research Organization CRO needed for non-GLP Study: Fluorescence microscopy. Fluorescence density in lung and spleen from mice. The mice have been injected with fluorescence labelled erytrocytes and the intention is to investigate trapping of these cells in spleen and lung.

Closed

13-00773

Eastern USA FDA GLP-compliant preclinical laboratory needed to perform pre-clinical research using an in vitro micronucleus assay using human peripherical blood lymphoctes.

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13-00728

ISO, FDA GMP California preclinical contract research organization CRO needed for preclinical testing: sterility/endotoxin/mycoplasma (according to 21 CFR and USP 71), viruses (CMV, HIV-1 & 2, HTLV-1 & 2, EBV, HBV, HCV, B19)

Closed

13-00700

Europe Preclinical Contract Research Organization needed for preclinical evaluation of an experimental vaccine to explore the antibody response in rodent, to a vaccine of interest with 2 vector constructs, 1 expressing a virus-like particle based on the gag gene of murine leukemia virus, and another expressing a peptide of interest fused to a PDGF receptor sequence for surface expression. When these constructs are transfected into a mammalian c ...

Closed

13-00695

Preclinical contract research organization needed for preclinical testing: Pharmacology study , proof of concept in primate animal models of type 2 diabetes We would like to test the efficacy of a compound on lipid and glucose metabolisms in a monkey model of diabetes

Closed

13-00663

India preclinical contract research organization needed for implantation and extractable testing of LDPE+BaSo4 as per 10993 and 12418 standard

Closed

13-00660

USA Preclinical Contract Research Organization CRO needed for Lc50 Ld50 testing

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13-00645

Europe Preclinical Laboratory needed for toxicological assessment and genotoxicity studies for one of our active pharmaceutical ingredients (API).Structural Assessment, Hazard Evaluation and Classification, Qualification of Level present and/or Safety Testing (AMES), Risk Assessment We are currently at the first step of the process (molecular identification of the impurities in the API). Would it please be possible to recieve cost details an ...

Closed

13-00633

USA preclinical laboratory contract research organization needed for preclinical testing of ophthalmic vancomycin formulations 3 formulations of vancomysin antimicrobial testing vs. standard

Closed

13-00603

Preclinical and Clinical Contract Research Organization needed for preclinical studies and clinical studies: 1. An Neutralizing Ab test to screen and identify animals and people with neutralizing antibody toour gene therapy vector, and 2. a CTL (Elispot) assay to measure CTL responses to our Gene therapy vectors.

Closed

13-00530

USA Preclinical Contract Research Organization CRO needed for preclinical proof of concept study: Stereotactic injection of 6-hydroxydopamine to lesion the striatum of mice and rats. Follow up with injection dopaminergic neuronal precursors for testing of a Parkinson's disease cell therapy. The animals will need to be housed for an additional 18 weeks after transplantation with periodic behavioral assays including amphetamine-induced rotations, a ...

Closed

13-00361

Medical Device Preclinical Laboratory needed for implantation of a PMMA bone cement with bonded P32 radionuclide into the vetebrae and spinal canal of sheep or goat

Closed

13-00332

Canada or USA Preclinical laboratory needed for Standard chronic dermal testing are rat prenatal testing to demonstrate presence/or absence of teratological results of dermally applied product. To meet OECD requirements for mosquito repellents re. chronic dermal and pre-natal testing.

Closed

13-00288

India Preclinical laboratory needed for in-vivo molecular study of In-vivo Antihelicobacter pylori activity

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13-00271

Preclinical laboratory needed for in vitro testing 1) In Vitro Coagulation test2) InVitro Bio-adhesive strength measurement3) Primary skin irritation test4) Intracutaneous test5) systemic injection test6) Determination of efficacy of novel dressing in a lethal artrial model in swine7:EN 14476 Quantitative Suspension Method for Virucidal Activity

Closed

13-00203

UK Preclinical Contract Research Organization CRO needed for In vitro testing of natural berry extract against H3N2 human virus strain

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13-00190

Europe preclinical laboratory needed for anti-bacterial testing of four market drugs to be antibiotic. And here I would like to ask, is it possible for you to help us testing their anti-bacterial activity across five strains?

Closed

13-00168

Preclinical Contract Research Organization CRO needed for non-GLP preclinical pharmacology testing of experimental therapeutic Cynomolgus monkey model of age-related macular degeneration

Closed

13-00114

Preclinical Laboratory, Contract Research Oranization CRO needed for Influenza vaccine proof-of-concept studies. Peptide immunizations in HLA-transgenic mice followed by inoculation with WSN virus (BSL-2). Monitoring of clinical signs, morbidity, and mortality, and in vitro immunogenicity studies (FACS for antigen-specific T cells). Client will cover transgenic mice costs (from Taconic) and peptides (commercial synthetic)

Closed

13-00106

Asia or India Preclinical Laboratory, Contract Research Organization CRO needed for non-GLP in vivo efficacy study for prostatomegaly or prostatitis Standard outline at Laboratory

Closed

13-00102

California UL certification laboratory needed for UL Certification testing: UL Field Label Test and Certification. 1 each Cellvizio® Confocal Endomicroscopy system for GI endoscopy, bronchoscopy and preclinical imaging.

Closed

13-00058

Preclinical Contract Research Organization CRO needed for preclinical study.

Closed

13-00056

FDA GLP Preclinical Contract Research Organization CRO needed for FDA GLP Preclinical Study: In vitro testing of intranasal drug delivery device. Protocol development and implmentation.

Closed

13-00021

India Preclinical Contract Research Organization CRO needed for preclinical study screening of anti-malarial activity of medicinal plants

Closed

12-2359

USA, Canada, UK or Europe Contract Research Organization CRO with established mouse model of Thrombotic Microangiopathy needed for non-GLP Preclinical Pharmacology Testing. The activity of experimental test compounds shall be tested in this model

Closed

12-2312

Europe or USA Preclinical Contract Research Organization CRO needed for immunohistochemistry studies of monoclonal antibodies on fresh frozen normal human tissue panels

Closed

12-2310

Pharmaceutical Preclinical Contract Research Organization needed for preclinical study of compound tested in a mouse or rat bleomycin-induced lung fibrosis model, including prophylactic and therapeutic dosing schedules.

Closed

12-2298

North America AAALAC Accredited Preclinical Contract Research Organization CRO needed for preclinical in vivo studies in rodents testing the effect of an experimental compounds on bleeding times"

Closed

12-2265

FDA GLP Preclinical Laboratory needed for GLP preclinical study. Preclinical analysis of TSH, T3 and T4 in rabbits. 30 samples.

Closed

12-2247

USA Preclinical Laboratory needed for Non-GLP Preclinical Pharmacokinetic / Pharmacodynamic Study: Preclinical PK/PD NHP (cyno), 7 week study n=30, subcutaneous dosing, weekly serial bone marrow collection, whole blood and serum collection, and ability to perform FACS and Elispot, or alternatively provide lab space for us to do these assays."

Closed

12-2201

USA Preclinical Laboratory needed for preclinical in-vitro testing: culture bovine epithelial cells, incubate with test samples and contols, draw off supernatant and extract RNA for downstream testing by others. Must have direct experience with culturing and working with bovine epithelial cells. RFP available.

Closed

12-2162

New Zealand Preclinical Laboratory needed for HIV Testing of aluminum would provide an impermeable barrier to HIV

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12-2135

FDA GLP Preclinical Laboratory needed for ISO 10993 biocompatability Testing of Permanent injectable device; need cytotoxicity, sensitization, Irritation, systemic toxicity, subacute toxicity,implantation, hemocompatability, Chronic Toxicity. Do not need Carcinogenicity.

Closed

12-2108

Need the following preclinical toxicology services from one CRO and/or Preclinical Laboratory: 1) LDH Toxicology Assay in neurons 2) Silver stain histology toxicology assay 3)Pilocarpine induced status epilepticus (This is a model of prolonged seizures)

Closed

12-2021

USA, preferably East Coast USA FDA GLP preclinical laboratory needed for bioanalytical testing: GLP-1, GIP Glucagon like peptide 1 Gastric inhibitory peptide Human blood Possibly 90 samples

Closed

12-1885

USA FDA GLP Preclinical Laboratory Contract Research Organization needed for In-Vitro Testing: In vitro assays to gauge efficacy of treatment agents in addressing autoimmune modulation in the presence of mastitis-induced inflammation and infection, to include inflammatory agents such as PMA for positive control as well as three (3) known bovine mammary pathogens. Up to six (6) test samples will be provided. RFP is available.

Closed

12-1881

Preclinical laboratory needed for adventitious agent testing for a measle vaccine.

Closed

12-1860

India Pharmaceutical Preclinical Laboratory needed for in-vivo anti-cancer study: Research studies of a compound for anti cancer activity using Allograft model

Closed

12-1829

USA FDA GLP Preclinical laboratory, Contract Research Organization needed for GLP Preclinical Study: ELISA cytokine and EMSA NF-kB in vitro experiments to assess bioactivity of six (6) water-based treatment agents in a single dilution plus one positive and negative control each, run in triplicate, utilizing freshly isolated human PBMC cultured for 24 hours and obtained from previously frozen cells of a single donor. To include 5-8 page report wi ...

Closed

12-1812

FDA GMP Preclinical Laboratory needed for FDA preclinical testing to: ASTM F2458, F 2258, F2256, and F2255 for adhesive on porcine skin - split thickness skin graft

Closed

12-1788

Pharmaceutical Preclinical Laboratory, Contract Research Organization needed for preclinical IACUC in vivo study. Testing anti-asthma compounds in an in vivo OVA mouse asthma model. Endpoints should include AHR, cell differential counts and cytokines in BAL, and lung histology.

Closed

12-1771

Preclinical Contract Research Organization CRO needed for in vitro testing for 25 molecules checking possibility various activity for appetite, addiction, memory, depression, analgesic, bipolar disease.

Closed

12-1770

Preclinical laboratory needed for Non-GLP preclinical testing and pk testing. Preclinical with established model of ischemia/reperfusion in the kidney of rats. We would like to do PK at the same time. It will be a non-GLP study.

Closed

12-1729

Singapore, Europe and USA FDA GLP Preclinical Contract Research Organization CRO needed for preclinical efficacy study. CRO must have validated allergic rhinitis animal model for a preclinical efficacy study. The test article would be "a short peptide (within 20 amino acids)" and we would like to evaluate the efficacy against Allergic Rhinitis (AR) in the efficacy model studies including as many appropriate evaluation parameters as possible.

Closed

12-1697

USA, Europe, China, or India Preclinical Laboratory CRO Contract Research Organization needed. Bio-Analytical laboratory services needed for single analyte Pharmacokinetic Studies. pK testing of 900 samples study. Please provide us a quotation for Bio-analytical cost per sample (single analyte)in US Dollars. Additionally, we are also looking for quotaions for complete BE study i.e. Study design, Protocol writing, Pk analysis till final study repo ...

Closed

12-1696

Asia or India FDA GLP Preclinical CRO Contract Research Organization needed for GLP Preclinical studies: toxicity studies, skin irritation studies, patch testing, elution assay for medical device. FDA GLP Animal model studies for nanaosilver bandages

Closed

12-1635

Preclinical Contract Research Organization CRO needed for preclinical Efficacy study of treatment modality for C. difficile in a animal model. Histopathology samples to show difference in test vs controls.

Closed

12-1626

Pharmaceutical Preclinical Contract Research Organization needed for preclinical efficacy study testing. Preclinical bladder cancer efficacy study of novel agents dosed into the bladder. Orthotopic rat bladder cancer model

Closed

12-1587

USA Preclinical Laboratory needed for in-vivo studies: Tissue collection of Hypothalamus and prefrontal cortex RNA isolation and RT-PCR of markers 5/group 10 groups

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12-1573

Pharmaceutical FDA GLP Preclinical Contract Research Organization CRO needed for GLP Preclinical studies of New Chemical entity NCE in dog model of acute inflammation.

Closed

12-1569

USA Preclinical Laboratory needed for Preclinical Testing: Measuring CD34 and/or CD34//CD45/CD140b/CD31/CD133 - 2 samples pre and post treatment of 10 patients at a rate of 1-2 patients per day one to three times a week until 10 patients are reached

Closed

12-1558

Preclinical Contract Research Organization CRO needed for tumor model studies performed in mice with syngenic tumor models combined with immunotherapy.

Closed

12-1543

USA Medical Device Preclinical Laboratory needed for ISO Medical Device Testing to ISO 11970, Ophthalmic implants -- Intraocular lenses -- Part 5: Biocompatibility including Genotxocity Testing, Dioptric power, Image quality,exhaustive extraction, leachables,hydrolytic stability, photo stability, NdYag laser exposure,insoluble inorganics, genotoxicity, sensitization, seal closure integrity, microbial barrier,vibartion test, drop testing,

Closed

12-1457

Preclinical Contract Research Organization Laboratory needed for preclinical in vivostudy: in vivo efficay rodent alveolar bone loss modelLooking for facility with capabilities and familiarity in vivo efficacy rodent model for alveolar bone loss due to periodontal disease

Closed

12-1454

Pharmaceutical Preclinical Contract Research Organization Laboratory needed for preclinical testing study for Influence on hemoglobin oxidation Influence on lung artery blood pressure Influence on gases concentration in blood Influence on pH of blood

Closed

12-1444

Preclinical Laboratory needed for Cardiac Calcium Channel screen testing

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12-1443

USA and EU preclinical laboratory needed for renal inflammatory disease model study testing

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12-1398

Asia FDA GLP certified preclinical laboratory Contract research organization needed for Toxicology/preclinical study for vaccine candidate

Closed

12-1383

Non-GLP Preclinical Laboratory Contract Research Organization CRO needed for Non-GLP Preclinical Study for testing a new drug candidate in a small animal model of influenza, analysis of cytokines, lung/airway histology,RNA analysis.

Closed

12-1346

Africa or Europe FDA GMP Preclinical Contract Research Organization, CRO needed for Preclinical in vivo testing Safety testing of biologicals in non-human primates

Closed

12-1318

Large Pharma needs Preclinical CRO Contract Research Organization for non-GLP Preclincial Study on the Long term measurement of glucose and insulin for long duration of active agents. MUST be experienced and familiar with the Euglycemic clamp model in dogs or pigs.

Closed

12-1289

Preclinical Laboratory needed for Preclinical Testing: preclinical animal studies for Pharmaceutical Efficacy and safety assessment of a radioactively (131-I) labeled ligand on tumor-bearing mice.

Closed

12-1282

Canada, USA FDA GLP AAALAC Preclinical contract research organization CRO needed for GLP Live-Attenuated Vaccine TestingOur company has a candidate live-attenuated Influenza A vaccine we would like to test for efficacy in ferrets. This would be a pilot sized study that if successful could develop into a much larger cohort.

Closed

12-1257

West Coast USA clinical and preclinical laboratory needed for preclinical testing and analysis of recently created anti-hair loss/hair thinning products as well as field or clinical tests for efficacy

Closed

12-1231

Europe FDA GLP Preclinical Contract Research Organization needed for FDA GLP Preclinical testing: in vivo toxicology, pharmacology Toxicology, safety pharmacology, regular pharmacology for example in cancer models in large and small animals. perform the indicated test and submit the information to the person named below.

Closed

12-1182

Preclinical Laboratory needed for chemical efficacy testing against Hand, Foot, and Mouth Disease (HFMD).

Closed

12-1167

Africa FDA GLP Preclinical Laboratory needed for GLP research adn development viral testing on HIV/AIDS new research

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12-1158

USA preclinical laboratory needed for ISO biocompatibility testing and toxicology testing to: ISO 140150 Buehller Method 900899ISO 910699 1 (cytotoxicity) 2 (sensitization) 3 (irritation or IC)

Closed

12-1123

India Preclinical Toxicology Laboratory needed for Intracutaneous Reaction Studies 1.Glass Ionomer cements a) Restorative/Luting Cement b) Restore+ Condensable cement-Used in dentistry as luting agents, pulp-protecting agents or cavity-lining material 2.Nickel- Metal-used in dental arch wires 3.Titanium-Metal-used in dental arch wires 4.SS-316-Metal-Standard Stainless steel used in dental arch wires 5.17-4 Ph-Metal-used in dental Brackets ...

Closed

12-1122

India Preclinical Toxicology Laboratory needed for ISO In-Vitro Cytotoxicity Testing of to ISO-10993-5: Dental cement- 2 different samples Nickel, Titanium, SS-316-Metal,17-4 Ph-Metal

Closed

12-1099

ISO preclinical toxicology laboratory needed for toxicokinetic studies on absorbable hemostats - collagen and ORC/cellulose material. would like to do toxicokinetic test and antimicrobial test

Closed

12-1081

USA Non-GLP Preclinical Laboratory Contract Research Organization needed for non-glp preclinical study: 6 week bilateral posterolateral fusion in athymic rats; we would want high definition X-rays at point right after implantation and at 6 weeks

Closed

12-1055

FDA GMP Medical Device Preclinical laboratory needed for ultrasound gel testing for Acoustic speed measurement (m/s) Acoustic Attenuation Coefficient (dB/cm/MHz) Acoustic Impedance Measurement (MRayl) Electro conductivity (mS/cm)

Closed

12-1019

India Preclinical Bioanalytical Laboratory needed for Leukotriene testing Leuokotriene estimation 10 samples

Closed

12-1002

Europe ISO Preclinical Laboratory needed for INTRAOCULAR IMPLANT TESTING ACCORDING TO EN ISO 11979-5. Two type of IOLs implanted in 12 adult rabbits, six for each type of IOLS.

Closed

12-0996

USA Pharmaceuticals Preclinical Contract research organization CRO needed for non-glp preclinical study for bleomycin lung injury model in rodents

Closed

12-0994

India Preclinical Laboratory needed forpreclinical testing of two cytokines (IL-6 and TNF-alpha) in rats, 90 samples of each cytokine

Closed

12-0992

INDIA OR ASIA PRECLINICAL LABORATORY NEEDED FOR ISO, ASTM, USP PRECLINCIAL TESTING: IN-VITRO BREAKING STRENGTH RETENTION TEST FOR ABSORBABLE SURGICAL SUTURE

Closed

12-0985

Preclinical Contract Research Organization CRO needed for preclinical study for Congestive Heart Failure animal models.

Closed

12-0883

FDA GLP Preclinical Contract Research organization CRO preclinical toxicology laboratory needed for GLP Study: Ototoxicity study in guinea pig

Closed

12-0870

FDA GLP Preclinical Laboratory needed for FDA GLP compliant osmolarity testing for preclinical support of a liposomal drug product.

Closed

12-0835

Asia FDA GMP Preclinical Laboratory needed for preclinical phramacokinetic pharmacodynamic validation method methodology agent of control QC CALIBATION CURVE CONCENTRATION ABSORBTION ELIMINATION DISTRIBUTION CMAX TMAX TOXICITY GULIDLINE DESIGN PROTOCAL SOFTWARE SAMPLE BLOOD INTERVAL TIME analytical chemistry pure agent GUILDLINE METHODOLOGY VALIDATION METHOD ABSORBTION HALF LIFE 100 SAMPLE

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12-0812

New Jersey Contract Preclinical Laboratory needed with equipment and experience performing rat pulmonary arterial hypertension model(s)."

Closed

12-0792

Large pharma needs UK FDA GLP Preclinical Toxicology Laboratory for coombs test in dogs

Closed

12-0781

FDA GLP Preclinical Laboratory needed for GLP Biocompatibility Testing of medical devices - limited contact with intact skin: - cytotoxicity Tests-ISO 10993-5 - sensitization Tests-ISO 10993-10 - irritation Tests-ISO 10993-10 and implant efect ISO 10993-6

Closed

12-0777

Preclinical Toxicology Laboratory needed for cytotoxicological testing of crude herbal extract extracted from desert shrub wildly growing in Thar Desert of Rajasthan, India.Further research is required for purification and fractionation of this extract for various formulation from its active bio molecules to be used as anti-cancer agents

Closed

12-0775

India Preclinical Toxicology Laboratory needed for cytotoxicological testing of crude herbals prepared from desert shrub Leptadenia Pyrotechnica. Please, let me know your terms and conditions along with the charges. Hope to get quick reply.

Closed

12-0768

India FDA GMP Preclinical Laboratory needed for GMP bioavailability / bioequivalence testing: BA/BE studies and we require bio assay tests to be done for all the studies we undertake

Closed

12-0760

Pharmaceutical Preclinical contract research organization CRO needed for in vivo study testing of embolic MCAO model in rats

Closed

12-0746

ISO Pharmaceutical Toxiology Laboratory needed for preclinical Studies: Cytotoxicological testing before pre-clinical testing of herbal crude extract from Thar Desert medicinal plant Leptadenia pyrotechnica(Kheemp) further research is required to develop medicine from this extract for treatment of cancer.

Closed

12-0744

Medical Device Preclinical, Clinical Laboratory needed for Condom-Compatibility Testing of Personal Lubricant 1) Condom Test: Compatibility Study (Lubricants), Tensile2) Condom Test: Compatibility Study (Lubricants), Air Burst3) Cytotoxicity4) Sensitization5) Irritation: Vaginal, Anal6) Systemic Toxicity

Closed

12-0730

Pharmaceutical Preclinical Laboratory needed for cell line testing for compound activity in oncology cell lines for proliferation, cytotoxicity, apoptosis. Require a panel of solid tumor cell lines (information on available cell lines e.g. microarray, mutation, amplification) also interested in a panel of leukemia/lymphoma cell lines

Closed

12-0729

TOronto FDA GLP Preclinical Contract Research Organization CRO needed for GLP study with rats where our products can be evaluated by IV route, administrated daily during 4 weeks and 2 weeks of recovery period.

Closed

12-0633

FDA GLP Preclinical Laboratory needed for GLP Biocompatibility Testing - limited contact with intact skin: - cytotoxicity Tests-ISO 10993-5 - sensitization Tests-ISO 10993-10 - irritation Tests-ISO 10993-10

Closed

12-0628

Non-GLP Contract Research Organization, Preclinical Laboratory needed for Non-GLP PK Studies, Pharmacokinetic testing of drug discovery compounds (IV and PO dosing) to support future toxicology studies

Closed

12-0595

USA FDA GMP Preclinical laboratory, Contract Research Organization needed for FDA GMP Preclinical Studies: Testing various hemostatic products on animals in animal surgical model. basic rodent, sheep, rabbit or pig study. May perform frequent multiple surgery.

Closed

12-0582

AAALAC Pre-clinical Contract Research Organization CRO needed for preclinical study: efficacy of Spondyloarthropathy animal model efficacy testing needed. Proteoglycan induced arthritis (PGIA), HLAB27tg rat model, or other.

Closed

12-0554

US FDA GMP Pharmaceutical Preclinical CRO needed for FDA Vasoconstriction study as per FDA guidance on topical corticosteroid.

Closed

12-0540

Europe FDA GLP, GMP Preclinical Bioanalytical Laboratory needed for Pre-clinical formulation development, GLP analytical and bioanalysis support for toxicology, metabolism and clinical trials.

Closed

12-0518

Preclinical Contract Research Organization needed for preclinical study of a novel drug in HIV therapy. Please let me know if this is one of the services you provide. Many thanks

Closed

12-0492

CNS Preclinical Laboratory, Contract Research Organization CRO needed for preclinical efficacy studies to screen 3-5 compounds in non-mammalian in vivo models for CNS disorders e.g. AD, PD, ALS etc. We're interested in Drosophila, C. elegans or zebra fish modals

Closed

12-0489

Europe Preclinical Contract Research Organizaiton needed for FDA GLP and non-GLP pharmacokinetic studies, pK testing toxicology testing Beagle dogs PK, tox

Closed

12-0411

San Diego, California Non-GLP Preclinical Laboratory needed for Clinical pathology non-glp Preclinical testing

Closed

12-0391

USA GLP Preclinical Laboratory needed for GLP Study, vaccine testing: Growth of Live-attenuated Influenza vaccines in embroynated Chicken eggs with the capabilities and experience of growing Influenza A virus in embryonated Chicken Eggs. The CRO would be responsible for growing 2-4 Influenza A virus strains in chicken eggs as well as determine the growth phenotype (one-step kinetics) via Hemagglutination assay, TCID50, an/or Plaque assay."

Closed

12-0389

Non-GLP preclinical laboratory needed for animal skin wheal and flare testing. Need quantitative readout of novel compound vs. histamine skin response

Closed

12-0359

Europe GLP Preclinical Laboratory needed for Performance Evaluation of specificity of new HBsAg ELISA diagnostic kit in accordance with CTS (5000 camples of unselected donors in parallel with CE-marked ELISA kit)

Closed

12-0334

Large Corporation needs Asia non-GLP and GLP Preclinical laboratory for pharmacokinetic studies: pk, biodistribution studies, animal tumour models

Closed

12-0312

Canada, USA FDA GLP Preclinical Contract Research Organization needed for GLP Biocompatiability Study: ASTM F719-8, Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation. (Biocompatibility) AAMI / ANSI / ISO 10993-16:1997/(R) 2009, Biological evaluation of medical devices - Part 16: Toxicokinetic study design for degradation products and leachables from medical devices. (Biocompatibility)

Closed

12-0307

EMA, FDA GMP Preclinical Contract Research Organization needed for preclinical study: antibacterial activity of two medicinal products on the model of rabbit corneal abscess.

Closed

12-0289

Preclinical Contract Reseach Organization needed for full preclinical testing for new compound for diabetes

Closed

12-0257

FDA Non-GLP preclinical microbiology laboratory needed for non-glp Confirmative in vitro Testing for Determining Tuberculocidal Activity - NON GLP expand the scope of microorganisms that our line of environmental surface antimicrobial products are capable of killing, we are investing resources into developing a Mycobactericidal disinfectant that will meet the requirements of the United States' EPA's II. Confirmative in vitro Test for Determining ...

Closed

12-0203

USA FDA GMP Preclinical Laboratory needed for Substantially equivalent evaluation in simulated use test for common human blood analytes collected from capillary puncture.

Closed

12-0191

West Coast USA Preclinical Laboratory needed for thrombogenicity testing of a medical device

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12-0190

USA EPA, FDA, GMP, GLP preclinical product safety, toxicology laboratory needed for FDA GLP studies: allergenicity/ toxicity / product safety laboratory needed, in India or abroad, for a protein molecule, likely to be consumed as a food constituent in future. The protein will be supplied after purification and lyophilization.

Closed

12-0160

Preclinical laboratory needed for in-vitro testing of plant extract and/or topical cream for in vitro activity against Herpes simplex (HSV-1 & HSV-2)

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12-0069

Preclinical Laboratory, Opthalmic Contract Research Organization needed for preclinical study of precision drug deivery system. nonterminal canine studies for our precision ocular drug delivery device. Our need is immediate.

Closed

12-0048

FDA GLP Preclinical Contract Research Organization needed for GLP Testing of several compounds tested for efficacy in an HCVcc model.

Closed

12-0046

Europe FDA GMP preclinical laboratory needed for dissolution testing UPS 711 using apparatus 4 for a low soluble liquid formulation (methyl prednisolone acetate)

Closed

12-0045

ISO 17025 Preclinical Laboratory needed for Biocompatibility Testing of Hydrophilic Intraocular Lens 1) Hydrolytic Stability 2) Photostability 3) Nd.YAG exposure

Closed

12-0011

Preclinical Laboratory, Contract Research Organization needed for in-vivo safety testing and efficacy testing of therapeutic skin patches (nothing invasive or involving dissections) to test for safety and desired outcomes.

Closed

12-0002

India Preclinical Contract Research Organization needed for preclinical study for efficacy testing of Contraceptive efficacy of Novel Intrauterine Device Copper T 380 A

Closed

11-2778

USA FDA GLP GCP Preclinical COntract Research Organization needed for GLP Preclinical Bioequivalence Study - Pk testing and Tissue depletion studies in animal like cow and swine

Closed

11-2774

USA preclinical laboratory needed for preclinical contract influenza vaccine protection studies. N eed a poultry vivarium

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11-2773

USA FDA GLP preclinical CRO needed for FDA GLP compliant study open or lap procedure to insert clips, laparoscopic targeting procedure to hit preplanted clips. No follow-up. Require MRI for preop imaging and intraoperative "O" arm for intraop image acquisition.

Closed

11-2756

Eastern Europe EFI Certified Preclinical Laboratory needed for HLA typing

Closed

11-2712

Europe ISO / FDA GLP preclinical contract research organization needed for in vivo surgery medical device contract study for rabbit spine fusion

Closed

11-2659

Preclinical Laboratory Contract Research Organization needed for preclinical testing studies for skin sensitivity to Aluminum: In-Vitro (lymphocyte) testing with solid or soluble Aluminum/metals.

Closed

11-2658

USA FDA GLP preclinical laboratory, contract research organization needed for preclinical safety toxicology As part of IND filing, we need to generate safety toxicology data from Pigs' various tissues, the target organ will be heart. Studies will be done in our facility, tissues can be send to your facility for toxicity studies. We require toxicity report from a certified veterinary pathologist, Mainly histopathology data.

Closed

11-2567

Preclinical Laboratory Contract Research Organization needed for preclinical toxicology studies, ISO 10993 - cytotoxicity, sensitization, irritation electrode, surface skin contact, it is applied for less than 4 hours. A current passes through it after it is wetted, with typical values of 5 mA, 30 Hz, biphasic pulses. It is a part of a functional electrical stimulator used on rehabilitation of stroke and spinal injury patients. The materi ...

Closed

11-2560

Preclinical Laboratory, Contract Research Organization needed for in vivo pharmacology In vivo efficacy testing in an ADHD or impulsivity relevant animal model

Closed

11-2532

FDA GMP, GLP Preclinical laboratory needed for in vivo testing of sunblock for UVA PA+++ value

Closed

11-2530

Europe, Canada, or USA FDA GLP Preclinical Genotoxicology Laboratory needed for Cytotoxicty, Ames and gene mutation test in Mouse lymphoma

Closed

11-2506

Pharmaceutical FDA GLP preclinical laboratory needed for in-vitro studies to measure in vitro binding characteristics Measuring in vitro binding characteristics of different formulations of injectable iron to transferrin. "

Closed

11-2499

USA FDA GLP Preclinical CRO needed for Final Product Release tests for an aerosolized lipid formulation of a cytotoxic chemotherapeutic agent for dosing by inhalation. Some tests require nebulizing and collecting aerosol; for example, Particle Size, % associated in the particles vs free ,etc. The Methods have been developed and validated, need to be transferred to the contract lab to test future manufactured Lot release.GMP final product release ...

Closed

11-02436

Europe Preclinical laboratory needed for non-glp preclinical studies Rat serum testosterone, RIA method, R&D, 60 samples

Closed

11-02421

Toronto Preclinical laboratory, contract research organization needed for Pre-clinical pharmacology studies: Laboratory with solid expertise in acute myocardial infarction in (mini) pigs"

Closed

11-02414

Non-GLP Preclinical Contract Research organization CRO needed for preclinical study with mouse model of food allergy

Closed

11-02389

Preclinical Contract Research Organization CRO needed for purity testing of 30 small melecule chemicals that need to be tested for their purity through NMR or LC/MS. Please provide quote

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11-02336

IACUC Preclinical CRO needed for non-GLP, grant-funded research for pharmaceutical efficacy of an asanguinous resuscitation fluid in canines. Under anesthesia, hemorrhagic shock will be induced surgically followed by resuscitation. Monitoring of dogs during the procedure and 4 days post-procedure is required. See: J. Vet. Pharmacol. Ther., 2001. 24(1):61-71. & Am. J. Ther., 2008. 12(2):98-101.

Closed

11-02334

Preclinical Contract Research Organization CRO needed for Influenza Virus Testing and Research : In vitro plaque inhibition assay, in vivo tests for example C23 mouse model

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11-02274

Midwest Preclinical Contract Research Organization CRO needed for Preclinical / clinical testing of OTC hand sanitizer Testing of provodone iodine based hand sanitizer in order to qualify as pre-op skin prep, pre-surgical scrub, health care personnel hand wash, methodology has dictated by FDA. 2. HRIT Testing, 3. Basic/Invitro microbiology test to evaluate efficacy of provodone iodine based antiseptic. 4. Ability to evaluate skin health/skin dama ...

Closed

11-02223

Preclinical toxicology Laboratory needed for Biocompatibility testing for dental products, and cytotoxicity result

Closed

11-02191

Preclinical Laboratory needed for USP Class VI testing on a 2-component Epoxy Adhesive with a Medical Application. Requires Animal Testing. How Many Samples?, Total-Testing-Time Required, $Cost, Description of Each Part of The Testing.

Closed

11-02177

Contract Research Oranization CRO, FDA GLP Preclinical Laboratory needed for Pharmaceutical Efficacy Study on Spinal cord Injuries to test efficacy of a Drug. The lab should have a strong expertise in intratehecal (IT) injection and IV, expertise in Intrathecal Drug dosing,and formulation compatible with IT injection, and local injection tox observed in IT injection.

Closed

11-02176

FDA GMP preclinical laboratory needed for efficacy study of transdermal patch which has been infused with natural vitamins and minerals. We need to test the efficacy of these products.

Closed

11-02093

Europe or Midwest USA FDA GMP, GLP preclinical bioanalytical laboratory needed for plasma testing. Must have validated method for anastrozole in human plasm

Closed

11-02078

Biologics Company needs Asia preclinical pharmacology laboratory needed for pharmacology study of Atherosclerosis in monkeys

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11-02070

Biotechnology Manufacturer needs preclinical CRO for starting preclinical toxicology studies for monoclonal aCD3 antibody taken orally. First study would be survey different species including monkeys to identify which one or more which can bind the anti human Mab. "

Closed

11-02061

FDA GLP Preclinical Laboratory needed for w 11-02060ell established solid tumor xenograft model for testing of a mAb. Receptor expression will be tested before starting.

Closed

11-02054

USA Preclinical Laboratory needed for preclinical testing: Detection of inorganic sodium periodate (and its species: sodium iodate and iodide) in an organic adhesive film made of poly(ethylene glycol).

Closed

11-02045

Australia preclinical laboratory needed for preclinical sudy testing thigh model, pneumonia, bacteremia

Closed

11-02019

Medical Device Preclinical Laboratory needed for ISO Testing to ISO 10993-1 of an implantable device in contact with blood (C-Permanente, more than 30 days), which correspond to all the tests detailed in Table 1 of this standard.

Closed

11-02010

UK Preclinical laboratory needed for TOC testing of nanoparticles

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11-01975

FDA GMP Preclinical Toxicology Laboratory needed for GMP Preclinical Toxicology Studies - Intranasal Toxicology, rat and rabbit, of an intranasal powder formulation. 5 groups of 10 male rats and 4 male rabbits.

Closed

11-01970

India FDA GLP preclinical laboratory needed for preclinical study to screen anti helicobacter activity (5 samples)

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11-01966

University Research and Development Laboratory needs Preclinical laboratory for xenograft study (about 7-10 animals per group) with a human leukemia cell line (K562) and NOD-SCID mice. We are interested in testing the anti-cancer activity of our drug (we can provide that to you) and we also have some information on preliminary doses.

Closed

11-01951

ICH, FDA GLP preclinical laboratory, preclinical contract research organization,CRO needed for GLP preclinical bioequivalence studies in Sheep, Goat and Cattle. We have few studies to be done.

Closed

11-01950

India Preclinical laboratory , Contract Research Organization needed for preclinical studies: Estimation of Tumor necrosis factor alpha, anti inflammatory cytokines, IL-1 and IL-6 in bronco alveolar lavage of mouse.

Closed

11-01942

Pharma company needs preclinical laboratory, Virology CRO Contract Research Organization totest a panel of clinically relevant HCV replicon resistance mutations with our HCV inhibitors. Either through transient transfection of mutant replicons or the use of a panel of cell lines persistently infected with mutant replicons. In particular this panel will hopefully cover roughly 10 known clinical resistance mutations and contain R155K, D168A, and A1 ...

Closed

11-01891

FDA GLP Preclinical Contract Research ORganization CRO needed for FDA GLP preclincial study: FDA pig cardiac arrest model needed for study study. 30-50 pigs study for up to 3 days

Closed

11-01855

Eastern US Preclinical Contract Research organziation needed for CLINICAL STUDIES, IN VITRO, EFFICACY, PERMEABILITY, ETC

Closed

11-01850

Large Pharmaceutical Manufacturer needs Bioanalytical Preclinical Laboratory for Assessment of commercially available POC flu testing kits

Closed

11-01848

Preclinical Product Safety laboratory needed for Irritation - intracutaneous injection Sensitization - Klingman Maximization L929 MTT Cytotoxicity

Closed

11-01837

India Preclinical Product Safety laboratory needed to test dialysis product for kidney disease patients in animals.

Closed

11-01829

Oncology North America Preclinical Laboratory, COntract Research Organization, CRO needed for ADCC, test for a therapeutic antibody (oncology)

Closed

11-01825

Research Scholar needs India Preclinical microbiology laboratory for microbial assays, antitumor studies for few of my samples (may be 30).

Closed

11-01813

Preclinical pharmacology Laboratory needed for study testing of a Monkey model of atherosclerosis and imagery (PET Scan)

Closed

11-01801

Preclinical Laboratory, Contract Research Organization needed for Non-GLP preclinical bleomycin induced pulmonary fibrosis mouse model. Need to conduct in vivo study and do end-point evaluation by histology (collagen deposit).

Closed

11-01784

India preclinical laboratory needed for biocompatibility testing for medical devices.

Closed

11-01783

Pharmaceutical Preclinical Laboratory COntract Research Organization needed for Animal model (preferentially mice)for E.coli EXPEC infection (UTI and sistemic infection)

Closed

11-01769

Pharmaceutical Preclinical Contract Research Organizaiton, CRO needed for in vivo psoriasis model "Testing in vivo efficacy of compounds in a well validated model of psoriasis is required. Access to previous active comparitor data is essential. "

Closed

11-01756

India API Manufacturer needs India preclinical contract research organization for General Toxicological studies (for a intravenous LD50 analysis) for an API product. Can you please provide us the proposal with details for carrying out the toxicity study at your site.

Closed

11-01697

India preclinical laboratory needed for Maxillofacial Silicone subjected to artificial aging.

Closed

11-01612

USA Non-GLP Preclinical Laboratory CRO needed for Non-GLP Quantitation of the antibiotic Cefazolin in porcine plasma (~150 samples)for PK determination.

Closed

11-01603

FDA GLP Preclinical Laboratory, CRO needed for ISO In-Vivo Testing of Medical Devices in vivo according to ISO 10993 (intradermal reactivity, acute toxicity, sensitization)

Closed

11-01566

Preclinical laboratory needed for in vitro antiviral efficacy models for herpes simplex virus.

Closed

11-01557

India Preclinical Laboratory, Contract Research Organization CRO needed for preclinical studies: acute,subacute and chronic preclinical toxicology studies using beagle dogs as test system

Closed

11-01542

Preclinical Contract Research Organization CRO needed for preclinical Immunization of (1)cattle, (2)cats, and (3) dogs. Approx. 8 groups of 5 animals each. Immunize & 1-2 boosts. Track by ELISA. Challenge with pathogen. Case 1: BSL2 organism, case 2: BSL3 organism. Duration 4-6 months.

Closed

11-01485

Preclinical Bioanalytical Laboratory needed for cross species antibody reactivity testing by immnoblotting Purified enzymes from different species were blotted with human McAb to determine the cross-species reactivity

Closed

11-01484

Florida preclinical contract research organization needed for implantation study with Nude Mouse subcutaneous implantation of medical device

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11-01478

Malaysia or Singapore Preclinical Labroatory needed for Analysis of the type of fatty acids contained in the mice feces. One batch 40 samples.

Closed

11-01391

Toronto Preclinical Laboratory needed for Mouse model toxicology testing for small molecule antimicrobial Maximum tolerated dose

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11-01364

FDA GLP Preclinical Contract Laboratory , pharmacology laboratory needed for GLP animal safety study on pigs, to check the safety of SQ infusion during 24 hours in 10 awake pigs (SPF MIXED RACE)."

Closed

11-01362

India, Asia or Australia FDA GLP Preclinical Contract Research Organization CRO needed

Closed

11-01327

USA Preclinical Laboratory Contract Research Organziation CRO needed for n vivo study of the wound bursting strength of cured medical adhesives. The study would measure the adhesive of 60 incisions (30 for each product) and measure the strength of the adhesive 1 hour after it was cured and 1 day after it was cured.

Closed

11-01310

Asia FDA GMP preclinical aboratory contract research organization needed that has validated method in analyzing doxofylline concentration levels in blood serum or plasma for a Pharmacokinetic and Bioequivalence study. Number of Samples: 150 samples

Closed

11-01309

USA and Asia Preclinical Contract Research Organization needed for Pharmacokinetic Study for glucaric acid analysis in blood serum / plasma samples for our pharmacokinetic study using HPLC or other validated method. Number of samples is 30-40.

Closed

11-01308

Neurology Preclinical laboratory needed to test auditory brain response ABRs in young mice with gene defects that lead to Usher IIIa disease. We are testing therapeutic compounds in mice aged from p6-p30

Closed

11-01304

Canada preclinical toxicology laboratory needed for Cytotoxicity, Genotoxicity, Immunotoxicological analysis and Ecotoxicological analysis Immunotoxicological analysis (Cell viability with human and mouse macrophages) 2. Ecotoxicological analysis (Kinetic luminescent bacteria test 3. Cytotoxicity(In vitro bioassays) 4. Genotoxicity(Ames test/Bacteriological assay) Materials: Potato starch based film and cellulose nanofibres.

Closed

11-01284

New York Preclinical Laboratory needed for HPLC of rodent blood samples to determine drug levels. Number of samples would be 200-400.

Closed

11-01281

Canada or USA FDA GLP Preclinical Product Safety laboratory needed for pre-clinical trial safety study for New blood filtration product to be used in conjunction with dialysis. Porcine animal model for safety study to support CE Mark.

Closed

11-01276

USA FDA GLP Preclinical Laboratory CRO needed for GLP measurement of N-acetyl-β-d-glucosaminidase (NAG), Neutrophil gelatinase-associated lipocalin (NGAL) and Kidney injury molecule-1 (KIM-1) in dog urine that has been frozen for 2-3 months

Closed

11-01261

Preclinical Laboratory needed to test for CT/NG on the BD Viper XTR platform or the BD Probe Tec.

Closed

11-01250

Pharmacology Preclinical Laboratory needed to determine the concentration of two water-soluble compounds that just produces lysis of the erythrocytes. To find the isotonic concentration of the compounds.

Closed

11-01238

Large mutlinational corporation needs FDA GMP Bioanalytical Preclinical Laboratory for Mouse Minute Virus (MMV) and Xenotropic Murine Leukemia Virus (XMuLV) Retention TestingPassing virus laden influent through filter device and detecting virus in effluent. Filtration is controlled.

Closed

11-01201

Pharmaceutical Preclinical Laboratory CRO needed for preclinical research testing to EC Directive for 15 products

Closed

11-01187

USA non-GLP Preclinical Laboratory CRO needed to Conduct in-vivo pharmacology / toxicology studies in animal model of bacterial infection.

Closed

11-01185

India preclinical laboratory CRO needed for assay of visfatin levels in rats.

Closed

11-01176

Europe Preclinical Laboratory needed for for pre-clinical toxicology studies in mice, rats and pigs for H&E and necrosis stains on tissue samples in these animals I hope you can help,

Closed

11-01173

USA non-GLP Pharmaceutical Preclinical CRO needed for in vivo pharmacology/toxicology studies in animal model of bacterial infection"

Closed

11-01160

USA Bionalytical, Preclinical Laboratory needed for PCR Testing: HIV-1/2, HBV, HCV by PCR on cryopreserved cells / tissue

Closed

11-01158

FDA GLP Preclinical Laboratory, CRO needed for drug absorption study following sublingual administration in comparison with iv in rabbits. Then we require a laboratory with analytical expertise too, in addition to the animals' treatment.

Closed

11-01136

Preclinical Toxicology Laboratory needed for a Wessler Model Test performed with rabbits for evaluation of procoagulant activity.

Closed

11-01119

CRO NEEDED FOR ANTI OBESITY CLINICAL TRIAL 1. Group 1: Placebo 2. Group 2: Active formulation (Formula 1) 3. Group 3: Active formulation (Formula 2 = Formula 1 + some other additives) 4. Parameters  Weight loss  Satiety  Blood analysis :Serotonin, Leptin, Ghrelin levels-15 DAYS ONCE  Urine analysis (formaldehyde, malonaldehyde, acetaldehyde, acetone and ketone)  DEXA estimate of fat mass and fat free mass ( 5. Blood and urine an ...

Closed

11-01115

Europe FDA GLP Preclinical Toxicology Laboratory needed for Nonclinical toxicological testing for pharmaceuticals

Closed

11-01096

USA or Canada Toxicology Laboratory needed for a preclinical study in Wessler Stasis model (rabbits).

Closed

11-01095

Toxicology Laboratory needed for a preclinical study: acute, subchronic, chronic mutagenicity, teratogenicity and carcinogenicity.

Closed

11-01065

FDA GLP Opthalmic Preclinical CRO needed for GLP preclinical efficacy of drug delivery device for NDA. Bioanalytical testing of aqueous humor samples for concentrations of latanoprost drug delivery device. Specifically, we need analysis that depicts the concentration of the drug Xalatan in the aqueous humor at nanograms (ng) per milliliter (mL) or other applicable increments from each sample provided for comparison. We will need written docume ...

Closed

11-01030

Preclinical Laboratory needed for in vivo testing, preclinical model rat spinal cord injury model

Closed

11-00986

non GMP/non GLP Preclinical Contract Research Organization needed for screening compound stability in human intestinal fluid. The real HIF should be used, not simulated HIF.

Closed

11-00974

Preclinical Contract Research Organization needed for preclinical murine proof of concept study for early phase discovery in antifungal field. One or several small molecules needs to be evaluated with respect to in vivo antifungal properties.

Closed

11-00941

Preclinical Contract Research Organization needed for testing: 1. In-vitro skin irritation 2. In-vitro eye irritation 3. Ames Test 4. Local Lymph Node Assay

Closed

11-00939

AAALAC Preclinical Contract Research Organization needed that has a validated model of allergic asthma in guinea pigs.

Closed

11-00924

Preclinical Contract Research Organization needed for preclinical pilot studies to test presence of shed cytokine receptors in human stool samples

Closed

11-00916

Preclinical Contract Research Organization needed for spontanious metastasis models in mice that have Bioluminescence (BLI) as well as the model for euglycemic clamp in dogs. We have compounds that we would like to test in these specific models.

Closed

11-00915

Preclinical Contract Research Organization needed for retinitis pigmentosa mouse model as a screening tool for new drugs- I need to see a protocol with the capabilities including positive control efficacy.

Closed

11-00912

USA Preclinical Contract Research Organization needed for receptor microscopic autoradiography testing.

Closed

11-00906

Preclinical Contract Research Organization needed for preclinical testing using Rodent pneumonia model (slowly healing or semi chronic) where the lungs have been inocculated with a mucoid Pseudomonas sp. Repeated treatment is a requirement (intratracheal and/or inhalation).

Closed

11-00887

Large Pharma needs Preclinical CRO, Contract Research Organization for Pharmacology, efficacy study with retinitis pigmentosa mouse model as a screening tool for new drugs

Closed

11-00836

GLP Preclinical Contract Research Organization needed for preclinical pharmacological/safety testing - Measurement of contractile force, APD using human heart tissue or isolated human cardiac cells.

Closed

11-00809

FDA Preclinical Contract Research Organization needed for toxicology, phase 1 nervonic acid testing.

Closed

11-00796

Australia Preclinical Contract Research Organization needed for typical dissolution study with Australia innovator opioid product

Closed

11-00772

EU, USA, Canada, Australia OECD GLP Preclinical Contract Research Organization needed for acute inhalation study with microorganism according to OECD 403

Closed

11-00762

Preclinical Contract Research Organization needed to aid Pediatric Dentist interested in testing patients for allergy to Eugenol (oil of cloves) used in dental practice as a sedative filling and primary tooth root canal filler. I would like to ELISA or RAST test a group of patients (approx. 100) initially and then may need to test a much large sample.

Closed

11-00755

USA Preclinical Contract Research Organization needed for preclincial study to measure OVA specific IgA to total IgA from eluates of mouse intestinal fluids. Would also like to have the anti-OVA IgG / total IgG measured for these same animals in the serum and intestinal fluids. There will be a total of about 10 experimental and control animals' samples.

Closed

11-00728

Preclinical Contract Research Organization needed for preclicnial study for biological activity of Insulin (a comparison study of - receptor binding, receptor activity, glucose uptake and mitogenic potency).

Closed

11-00715

India Preclinical Contract Research Organization needed for anti diabetic activity testing

Closed

11-00705

San Diego FDA GLP Preclinical Contract Research Organization needed for Preclinical Bioanalysis

Closed

11-00704

FDA GLP Preclinical Laboratory needed for GLP PK Study, Pharmacokinetic testing of animal plasma samples

Closed

11-00698

JMHW, OECD FDA GLP preclinical laboratory needed for preclinical study in rodent and nonrodent to evaluate a compound being developed as a prescription mouthwash. The studies would be used to support regulatory submissions globally

Closed

11-00680

USA Preclinical Contract Research Organization needed for Preclinical Pharmacokinetic testing in n=3 male and n=3 female monkeys, drug delivery and blood draws only (2) collection of urine and feces and cage wash for up to 72 hr (3) shipment of plasma and urine/feces on dried ice

Closed

11-00630

India/China FDA AAALAC GLP Preclinical Contract Research Organization needed for the following toxicology studies: Rabbit repeat dose toxicology. Rat reprodevelopment pilot and pivotal toxicology. Rabbit reprodevelopment pilot and pivotal toxicology.

Closed

11-00629

Canada FDA Preclinical Contract Research Organization needed for testing blood purifier

Closed

11-00626

China/India Preclinical Contract Research Organization needed to test the effect of rral administered drug on the development of Sjogren syndrome animal model

Closed

11-00625

FDA GLP Preclinical Contract Research Organization needed for testing a new color additive for AMDE, Short Term Toxicity in Rodents, Short Term Genetic Toxicity. The color additive is composed of two proteins in powder form. Necessary sample quantities will be provided.

Closed

11-00601

AAALAC, FDA Preclinical Contract Research Organization needed for neuroprotection study involving radiation-induced brain damage in rodents. Basic behavioral endpoints also needed as part of the study.

Closed

11-00555

India Preclinical Contract Research Organization needed for preclinical analysis and research

Closed

11-00519

Non-GLP Preclinical Contract Research Organization needed for the following studies: 1) PK/ADME in rats 2) Efficacy in rodent model of human cancer 3) single dose, acute toxicity in rats 4) repeat dose, subchronic toxicity in rats Four samples will be tested.

Closed

11-00490

US BSL-3, Non-GLP Preclinical Contract Research Organization needed for Preclinical Drug Development, efficacy testing of drugs on bacterial infections on animal model gut.

Closed

11-00489

US Preclinical Contract Research Organization needed to provide animal efficacy model for bacterial conjunctivitis.

Closed

11-00453

Non-GMP Preclinical Contract Research Organization needed for H1N1 efficacy testing of a formulated natural product

Closed

11-00446

Preclinical Contract Research Organization needed for preclinical toxicology study of Interferon drug: Toxicology Study: The study is required on 35 male Syrian golden hamsters using our interferon. This study is for 28-days toxicology study followed by a 7-days observation period. The main goal is to show the safety of our interferon alpha 2a with the reference product is essentially the same. The detailed protocol would be provided, Briefly it ...

Closed

11-00418

India FDA Preclinical Contract Research Organization needed for invitro antidiabetic mechanisms testing action of a herbal extract

Closed

11-00357

India Preclinical Toxicology Laboratory needed for Toxicity Study: Subacute 28 days toxicity Testing

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11-00253

GLP Bioanalytical Laboratory needed to test dog/rat/boar plasma samples for 4 preclinical studies scheduled during the second and third quarter of 2011.

Closed

11-00214

USA/Canada Preclinical Contract Research Organization for preclinical study to measure cardiovascular responses HR and BP over time - up to 24 hours in rats

Closed

11-00209

Europe Preclinical Contract Research Organization needed for preclinical study on novel postsynaptic channel blocker in a model of neuromuscular function such as the grip test, digital abduction test, etc. Need full dose responses versus control and reference cpds.

Closed

11-00208

University Research Center needs India FDA GLP, ISO Preclinical Contract Research Organization for In vitro testing of plant formulation for treating Hepatitis (A,B&C) -no. of Samples-2.

Closed

11-00205

Preclinical Contract Research Organization needed for preclincial efficacy study testing for efficacy data in an animal model system to determine efficacy of monoclonal antibodies via plasmaphoresis. In an animal model of inflammatory disease (e.g., collagen induced arthritis) need to attach a syngeneic anti-TNF monoclonal to a protein A column and then plasmaphorese the animal to determine if methodology has an impact on disease state.

Closed

11-00201

Preclinical Contract Research Organization needed for preclinical study, neonate mechanically ventilated piglet model of new born pulmonary hypertension

Closed

11-00188

Preclinical Contract Research Organization needed to conduct comprehensive investigation on substances with hypoglycemic action. We need research in the following areas: - Study of a model of action - Common Toxicity - Pharmacology - Genetic Toxicology - Influence on reproduction and fertility - Carcinogenicity - Ecotoxicity - Metabolism and pharmacokinetics - Histopathology

Closed

11-00153

USA FDA Preclinical Contract Research Organization needed to test our hair growing product on mice and/or clinical trials.

Closed

11-00148

India Preclinical Contract Research Organization needed for undertaking DOG study

Closed

11-00144

Preclinical Laboratory needed for preclinical tesing of a SNL model of Kim and Chung (tight ligation of spinal nerves) 2. CCI model of Bennett and Xie (loose ligation of the sciatic nerve) 3 doses + vehicle + standard compound, 10 rats per dose, 2 compounds to be tested

Closed

11-00132

Contract Research Organization CRO needed for Preclinical Study to study the effects of a series of molecules on the levels various pro/anti inflammatory cytokines in LPS/IGNg treated primary human tissue macrophages ideally lung and/or peritoneal origin. We also need to study chemotactic effects of these molecules in primary human tissue macrophages

Closed

11-00114

Preclinical Contract Research Organization needed for chemotherapy resistance testing per ASTM D6978-05

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11-00079

Preclinical CRO Contract Research Organization needed for preclinical study antitumor study testing for 10 samples for research purpose.

Closed

11-00077

Europe/USA Preclinical Contract Research Organization needed for in-vitro local tolerance test on reconstructed human oral epithelium for a new formulation of an already marketed medicinal product in agreement with the CPMP/SWP/2154/00 Emea guideline

Closed

11-00056

Preclinical Contract Research Organization that has preclinical obesity animal models needed for In Vivo efficacy/pharmacology testing. Please indicate the type of model available.

Closed

11-00045

Preclinical Contract Research Organization needed to conduct an efficacy study for our device on destroying or eliminating a live sample of tuberculosis.

Closed

11-00035

Non GLP Preclinical Contract Research Organization needed for preclinical screening inhibitors on mouse FAAH.

Closed

11-00028

Germany Non GLP Preclinical Contract Research Organization needed for testing Luciferase Plasmid with a new technology - Luciferase expression should be monitored by in vivo imaging after iv and stereotatic application

Closed

11-00017

Preclinical Contract Research Organization needed for performing an influenza challenge experiment with ferret model. Drug administration by infusion or intranasally. GLP is may be considered

Closed

10-03109

Europe Preclinical Contract Research Organization needed for testing to evaluate if our medical device (suited externally to the body)may harm pacemakers. We use radio frequencies radiation.

Closed

10-03067

Preclinical Contract Research Organization needed for rheological testing of elasticity and viscosity on samples of human mucus.

Closed

10-03063

Preclinical Contract Research Organization needed to use mouse model to test efficacy of new drug for hair growth in mouse androgenetic alopecia model--for research only; not needed for FDA submission

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10-03062

Eastern USA Preclinical Contract Research Organization needed for adenosine determination, pooled vitreous samples or serum-free media will be collected in ice-cooled syringes or containers, containing a stopping solution (50 £gM dipyridamole, 10 £gM erythro-6-amino-9-(2-hydroxy-3-nonyl)-purine hydrochloride (EHNA), 79 £gM £\,£]-methylene-adenosine-5.-diphosphate (AOPCP) in order to prevent cellular uptake, enzymatic deamination, or production fr ...

Closed

10-03058

Europe GLP Preclinical Contract Research Organization needed for tumor promotion (in vitro, ex vivo) and tumor promotion in vivo testing.

Closed

10-03028

Europe GLP/GMP Preclinical Contract Research Organization needed for toxicology testing - rabbit pyrogen test

Closed

10-03008

USA GLP/GMP Preclinical Contract Research Organization needed for Condom Safety Testing, Stability Testing, Animal Testing, and Spectrometer analysis

Closed

10-02987

USA GLP Preclinical Contract Research Organization needed for Complement activation assay

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10-02981

Preclinical Contract Research Organization needed for testing neonate mechanically ventilated piglet model of new born pulmonary hypertension

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10-02953

Large Packaging Manufacturer needs Preclinical Contract Research Organization for Toxicology Testing - Set up a test group to give the extraction from the composition of Oxygen absorber with the concentration of 5000, 2000, 300 and 30mg/kg , and then, to compare it, another test group to give a reagent excluding extraction of Oxygen Absorber. Use 5 rats for both test groups. Before dosage, rats are fasted for 4 hours. After weighting, make the o ...

Closed

10-02933

OECD GLP EMEA FDA Preclinical Contract Research Organization needed for Chronic Toxicity Studies sp: Cynomolgus monkyes Intravenous way weekly Administration by 6 weeks 2 level doses product 1 2 level doses reference product control groups: 3 animals/sex/group

Closed

10-02917

Europe Preclinical Contract Research Organization needed for Macrophage (monocyte) activity change test with serum GcProtein (GcGlobulin). Any macrophages including mouse or human will suffice. Probably peritoneal cells. Or RAW 264.7 cells. Now and each month.

Closed

10-02892

FDA GMP Preclinical Contract Research Organization needed for Host cell DNA impurity testing for product safety. Host is E. coli.

Closed

10-02887

USA FDA Preclinical Contract Research Organization needed for animal testing of medical device.

Closed

10-02850

Europe/USA Non-GLP Preclinical Contract Research Organization needed for screening a library for the inhibitory effect against HCV virus, using replicon assay

Closed

10-02842

Preclinical Contract Research Organization needed for two preclinical pharmacology studies - Microsurgery rat model: 1)distribution study with iodine-radiolabeled APL001, applied locally during microsurgery. Measurement of radiological activity by scintillation counter. 2)rat thrombosis model of microvascular anastomosis and measurement by flow probe and SEM. Local application of APL001 during microsurgery.

Closed

10-02839

Preclinical Contract Research Organization needed for measurement of inhibition of T-cell proliferation/activation in Mixed lymphocyte reaction (MLR) for five samples (dose-response)

Closed

10-02835

Preclinical Contract Research Organization needed for Preclinical In-Vivo Study, in vivarium testing options.

Closed

10-02828

USA FDA GMP Preclinical Contract Research Organization needed for early developmental stage study for cancer treatment: toxicology, bioavailability, pharmacokinetics, in vitro and in vivo efficacy as radiosensitizer and chemosensitizer.

Closed

10-02824

Midwest USA Preclinical Contract Research Organization needed for DNA Drug sensitivity testing - cytochrome P450

Closed

10-02814

Boston FDA GLP Preclinical Contract Research Organization needed for FDA Phae I IND Studies: Toxicokinetic and safety pharmacological studies on animal tissue including: 1) carcinogenecity, mutagenicity, and genotoxicity 2. Histopathology of diferent organs 3. Acute and repeated dose toxicity

Closed

10-02810

Westcoast USA Preclinical Contract Research Organization needed for in-vivo testing of potent compound, IV, IP, PO, rat in mouse

Closed

10-02743

Preclinical Contract Research Organization needed for stability testing of some newly synthesized gold(III) complexes that have been found to be more cytotoxic than cisplatin on in vitro tumor cell lines. We have also found these compounds to be stable in biological buffer and in the presence of reduced glutathione, but we would like to determine if they are stable in blood serum and in whole blood.

Closed

10-02741

FDA GLP Preclinical Contract Research Organization needed for testing: (1) carcinogenicity (6 month transgenic mouse) (2) Immunotoxicity with Adjuvant testing (3) Developmental and Reproductive toxicity

Closed

10-02736

Preclinical Contract Research Organization needed for 6 acute studies as well as Micro efficacy testing in order to file pesticide to the EPA.

Closed

10-02720

Preclinical Contract Research Organization needed for anticonvulsant activity testing in mouse or rat.

Closed

10-02715

USA FDA/CVM GLP Preclinical Contract Research Organization needed for 90 day feeding trial with 16 calves, full necropsy, pathology, histopathology.

Closed

10-02713

India Preclinical Contract Research Organization needed for testing acute dermal and sensitization of 0.5% permethrine (active ingredient)dissolved in Isopropyl alcohol and water in the form of an anti lice head lotion as per OECD guidelines.

Closed

10-02704

North America Preclinical Contract Research Organization needed for In vivo QT study n=4 or 6 NHP (preferably cyno) n=4 dog (Beagle preferably) QTc, QTf, QRS, T wave length

Closed

10-02702

Canada/USA/Europe/India Non GMP Preclinical Contract Research Organization needed for non-glp CNS drug toxicology study to determine the toxicology of a CNS drug candidate in mice. We would like to get an action plan for the TOX study in mice and the quantity needed ( Molecular weight about 700g/mol).

Closed

10-02672

India FDA Preclinical Contract Research Organization needed for Morphological Test, toxicological test, and Cu-extraction test of IUD

Closed

10-02659

China, Malaysia, Korea, Taiwan GLP, OECD Preclinical Contract Research Organization needed for Inhalation Toxicology(Dog)studies.

Closed

10-02649

Preclinical Contract Research Organization needed for Repellent Studies on a new organic compound derived primarily from the Neem tree with large concentrations of Azadirachtin as follows: 1) Mosquitoes knockdown 2) Knockdown and 3) repellent studies of bed bugs 4) Body Louse Testing

Closed

10-02646

USA Non GLP Preclinical Contract Research Organization needed to test ability of our formulation to inhibit infection of cell cultures with adeno virus and influenza virus.

Closed

10-02645

California GLP Preclinical Immunology Contract Research Organization needed for performing an in-vivo efficacy test, and would like to measure the levels of IFN-g and TNF-a and other major cytokines.

Closed

10-02626

USA Preclinical Contract Research Organization needed to evaluate whether a cpd inhibits diacylglyerol acyltransferase-1

Closed

10-02617

Preclinical Contract Research Organization needed for Glucagon Bioassay Testing in rat hepatocytes as per USP

Closed

10-02579

India FDA Preclinical Contract Research Organization needed for in vivo genotoxicity tests (micronucleus assay and chromosomal aberration test) for herbal product.

Closed

10-02568

Preclinical Contract Research Organization needed for testing as follows: 1. Microdialysis: Analysis of the changes in brain concentration of a molecule after administration of a test compound. Two or three doses plus vehicle, n=3. 2. CSF analysis: Analysis of the changes in CSF concentration of a molecule after administration of a test compound. One appropriate dose of the compound should be selected based on the results of the study 1, in addi ...

Closed

10-02551

USA/UK GLP Preclinical Contract Research Organization needed for TNA analysis for response to Anthrax vaccine

Closed

10-02542

Preclinical Contract Research Organization needed to test the local anesthetic properties of a chemical compound.

Closed

10-02540

India Preclinical Contract Research Organization needed for Caco 2 cell testing to study the bioavailability of carotenoids in food matrix. Number of samples may be 6 (max.)

Closed

10-02481

USA Preclinical Contract Research Organization needed for Interleukin 1-alpha and RANTES Testing

Closed

10-02464

Europe, USA, Canada, Asia GLP Preclinical Contract Research Organization needed for OECD 473 chromosomal aberration testing.

Closed

10-02452

AAALAC Preclinical Contract Research Organization needed to provide guinea pig OVA-induced asthma model - late airway response (whole animal respiratory chamber needed).

Closed

10-02447

Australia Pharma needs Preclinical Contract Research Organization for preclincial studies: animal and in-vitro toxicological and ecotoxicological studies, biodegradability and bioaccumulation data for NEP (N-Ethylpyrrolidone-2)

Closed

10-02420

Preclinical Contract Research Organization needed to perform USP dissolution studies for an extended release tablet of the Cravedilol, which is used for Cardivascular indication - would like to test the dissolution profile of our formulation to see if it Complies with USP requirements for dissolution testing of prolonged-release dosage forms with the following ranges: 90 min: 15-35% of label claim released; 180 min: 40-60% of label claim released ...

Closed

10-02391

Eastern USA ABSL2, BSL2 Preclinical Contract Research Organization needed to perform I.V. challenge of mice with MRSA. We would ship the mice to you for the challenge. We would also want to discuss setting up a Bacterial Load quantification of the kidneys.

Closed

10-02389

Preclinical Contract Research Organization needed for testing Mammalian toxicity of botanicals.

Closed

10-02380

FDA GLP Preclinical Contract Research Organization needed for Toxicology Testing and Biodistribution of an Adenoviral Based Therapeutic

Closed

10-02374

Preclinical Contract Research Organization needed for testing for Huntington's Disease.

Closed

10-02312

USA, Australia, Europe Preclinical Contract Research Organization needed for Oral toxicity testing LD 50 ( limit test) or ATC method

Closed

10-02296

USA FDA Preclinical Contract Research Organization needed for Viral testing for effectiveness on the treatment of RSV and rhinovirus.

Closed

10-02285

USA FDA GLP Preclinical Contract Research Organization needed for Preclinical Toxicology Study Testing: Dose Range-Finding study in mice (IV) Dose Range-Finding study in NHP (IA) Repeated Dose study in NHP (IA) Possible Repeated Dose in mice (IV) Test article is biologic

Closed

10-02267

USA Non-GLP Preclinical Contract Research Organization needed for Endotoxin testing in blood from Rhesus monkey.

Closed

10-02240

Europe GMP Preclinical Contract Research Organization needed for testing Porcine proinsulin-like immunoreactivity according to Ph.Eur. Limit is max 10 ppm. 3 batches.

Closed

10-02233

Preclinical Contract Research Organization needed for testing using HCC cell line to test the binding and the antitumor activity of the drug candidates

Closed

10-02229

Preclinical Contract Research Organization needed for time course study involving a GVHD animal model. Apoptosis studies cellular proliferation studies cell signaling

Closed

10-02202

Preclinical Contract Research Organization for evaluation of a Pneumonia Vaccine (Polysaccharide conjugated with diphtheria CRM197 protein) by im administration in an appropriate animal model.

Closed

10-02201

Preclinical Contract Research Organization for evaluation of a Flu Vaccine based on Cell Culture (inactivated influenza virus)by im administration in an appropriate animal model.

Closed

10-02200

Preclinical Contract Research Organization needed for evaluation of a Varicellar Zoster Vaccine (live attenuation virus)by sc administration in an appropriate animal model.

Closed

10-02199

USA Preclinical Contract Research Organization needed for In vitro cellular assay using radioisotope subtracts to measure triacylglyeride formation.

Closed

10-02196

Preclinical Contract Research Organization needed to test an animal model for corneal abrasion. Specifically, to test if a drug helps healing and/or prevents infection

Closed

10-02163

UK Preclinical Contract Research Organization needed for preclinical study: Franz Diffusion Cell, to compare release profile of a particular known species

Closed

10-02161

CHINA SFDA,FDA,GLP,USP,ASTM,ISO Preclinical Contract Research Organization needed to test the biocompatibility for medical devices such as stent or blood pooling bag.

Closed

10-02134

USA FDA Preclinical Contract Research Organization needed to test 14 rodents (rats) injected once under anesthesia(gas isofluorane), monitored for 30 days. Blood and urine collection x 4 (baseline, and 2hrs, 15days, 30 days post injection). Biopsy at day 15, tissue procurement at day 30.

Closed

10-02130

Preclinical Contract Research Organization needed for testing of pharmaceutical compound in a rat model of kidney transplantation modelling chronic allograft nephropathy

Closed

10-02129

PA, OH, MD Preclinical Contract Research Organization needed to conduct Large Scale Chronic and Acute Bioassays

Closed

10-02124

Preclinical Contract Research Organization needed for toxicology study for tumor promotion -we have isolated new phorbol esters which we suppose to cause tumor promotion similar to regular positive control (TPA) used for the studies. Please give us a feedback with other end parameters we could study during experiment.

Closed

10-02121

Preclinical Contract Research Organization needed for testing the effect of one of our drugs in the Concanavalin A induces acute hepatitis model

Closed

10-02120

Preclinical Contract Research Organization needed to test the effect of one of our drugs in an animal model (mice) of Uveitis

Closed

10-02106

Preclinical Contract Research Organization needed for testing the effect of drugs in development for lowering IOP and protecting the optical nerve in rodent models for Glaucoma

Closed

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