Contract Laboratory has received the following incoming Laboratory Test Requests which need to be fulfilled! These Laboratory Test Requests are received from a variety of sources ranging from start-up companies to large, multinational Fortune 500 corporations, international organizations, well-respected universities and government agencies that are actively seeking Independent, Third-Party Biotechnology Laboratories to perform their Biotechnology Testing, Analysis, Assays, Product Development, Scientific Research Experiments, Inspections, Certifications, and Engineering Projects. If you are a Biotechnology laboratory that would like more information on these Biotechnology projects, please visit Register Laboratories or call toll free 1-855-377-6821.
FDA GLP ISO-17025 bioanalytical laboratory needed for characterization of collagen scaffold medical device including amino acid analysis, quantification of Collagen I, DNA, GAG and lipids, protein assay, and trypsin resistance. residue analysis, hydroxyproline determination,
Molecular Biology / Bioanalytical Laboratory needed for up to three university-based experiments involving human cell lines:
Experiment #1: Test up to 5 human cell lines (i.e. liver, kidney, etc...). Formalinize these cell lines in order to have a bank ready to be used. Then culture peripheral blood stem cells,apply the different formalin treated cells into the growth media, and determine what occurs. I am looking to determine if differentiation is stimulated toward the cell lines that were added. Is there inhibition or is there no reaction?
Experiment #2: Culture peripheral stem cells, add various growth factors (ex. neupogen), and determine if cell expansion is stimulated
Experiment #3: Growth of autologous stem cells on an autologous feeder layer (cells and feeder layer from the same patient). Looking to find what numbers
Medical Device preclinical contract research organization CRO needed for insulin characterization with or without infusion through medical device: (1) High molecular weight proteins (insulin aggregates), (2) Preservative content (m-cresol), (3) Impurities, (4) Bioidentity (blood glucose response in rabbits), (5) Zinc content and (6) insulin recovery.
LONG TERM TESTING FDA cGMP microbiology laboratory needed for USP water testing of water for injection based on USP monograph for Sterile Water for Injection and the European Pharmacopeia (Ph. Eur.) monographs for Water for Injections in bulks and sterilized Water for Injections. Also need extractable volume and uniform volume.
Virology laboratory needed for conducting antiviral activity (HCV) screening using muteins targeted against replicons. Muteins: 3a genotype wild type, 1b Y93H genotype, 3 Y93H genotype , 1b L31V genotype, 1b L31M genotype, 3 A30K genotype.
Antiviral activity against replicons of genotype 1a, 1b or not.
FDA GLP Preclinical Laboratory needed for PCR viral testing of two regenerative drug products and raw materials using Pharmacopeia methods: 1. HIV (anti-HIV (I/II), 2. Human T-Lymphotropic virus I and II 3. Cytomegalovirus 4. Epstein-Bar virus 5. Hepatitis C 6. HBV (HBsAg & anti-HBC)
In order to stay in line with the pharmacopeia guidelines, we would like to perform detection of the former viruses on our products with the PCR method.
Contract Research Organization needed for pharmaceutical clinical study on pre-exposure prophylaxis (PrEP) in drug users (n = ~400). PrEP involves taking a daily dose of antiretroviral medication, Truvada (Tenofovir/emtricitabine), to lower individual's chances of acquiring HIV. As one of our primary outcomes, we are measuring PrEP adherence over time. Based on our preliminary research and correspondences with our collaborators, we found 4 different measures to assess adherence to PrEP (Tenofovir/emtricitabine).
1. Peripheral blood mononuclear cells (PBMCs) 2. Dried blood spots (DBS) 3. Hair collection 4. Single plasma samples
We want to know which assessment method would be the most helpful and cost-effective for measuring Tenofovir and/or emtricitabine adherence.
Dental distribution company needs viral & bacterial (live/viable) analysis from wipe/swab samples. Analysis should include identification of specific type of virus (i.e. hepatitis, HIV, etc.). Samples will be obtained from hard surfaces, such as: dental equipment, tools, etc.
GLP Compliant Laboratory needed for ongoing testing of regenerative drug development (Cell Therapy Hellas) Test for: 1. HIV (anti-HIV (I/II), negative <1.0) 2. Human T-Lymphotropic virus I and II 3. Cytomegalovirus (antibodies for cytomegalovirus IgG, negative ,6.0 AU/ml; antibodies for cytomegalovirus IgM, negative 0.9 IV) 4. Epstein-Bar virus (antibodies for Epstein-Barr IgG, negative 0.19 AU/ml; antibodies for Epstein-Barr IgM, negative 0.19 AU/ml; antibodies EBV-NA IgG, negative <0.91) 5. Hepatitis C (antibodies for hepatitis C, negative <1.0) 6. HBV (HBsAg & anti-HBC)
Clinical Research Laboratory needed for Food Nutritional Clinical Trials which will include plasma, serum, blood and DNA analysis for Changes in phosphorylation of mTor, AKT, Eif4E and rpS6 (muscle biopsy) Serum indices of skeletal muscle damage (creatine kinase and lactate dehydrogenase) Plasma insulin Blood glucose Plasma lactate Gene expression - mRNA expression of proteolytic markers Muscle glycogen Urinary indicators of protein breakdown (3-methyl-histidine and urea nitrogen)
Research Facility needed to conduct efficacy studies on biocides applications for the comparative assessment of biocidal products containing candidates for substitution in which the availability of efficacy test standards and laboratories is limited and biocidal-free alternatives may require another proof of efficacy than biocides.
Regenerative Medicine Company needs FDA GMP or GMP compliant bioanalytical laboratory for characterization studies on the residual antibiotic (aminoglycoside) content of various tissue products under development.Previous successful work in validating analytical methods per USP Q2(R1) a must.
Pharmaceuticals laboratory needed for biologic finish product testing (appearance, PH-value, osmolalitypolymer/Aggregate of HSA, Total protein content, Sterility, Endotoxin(LAL-Test), Biological Activity, Liquid particle count. It`s 4000 IU/ml.Please let us know the price, quantity and time of test (proforma)
Preclinical laboratory needed for performing a number of in vitro studies using stromal vascular fraction (SVF) cells.These studies involve labeling of SVF cells with magnetic microparticles and superparamagnetic iron oxide nanoparticles (SPION).
We want to measure the following parameters:
1-Assess cell viability, self -renewal capacity and proliferation capacity. of SVF cells exposed to SPION. 2-Confirm the intracellular uptake of SPION by SVF cells using one or more of the available techniques to determine intracellular iron or SPION content per cell (colorimetric assays: Prussian blue assay, Ferrozine assay; ICP-MS; ferromagnetic resonance; magnetophoresis; MACS). 3- Assess the ability of cells to retain the label throughout several cell divisions (dilution effect).
I will be happy to share any additional informatio
FDA GMP/GLP Pharmaceutical laboratory needed for stabiilty study, feasibility, method development and method validation of capillary IEF for quantitative testing of charge in pharmaceutical grade protein product (in buffer solution). Long-term sample testing, i.e. samples from stability studies.
LONG-TERM TESTING Genetics Laboratory needed for DNA sequence replacement. We have our own BAC that we would like to make 6 sequence replacements in. All but one are less than 200 bp and one is 13kb. We can provide the DNA sequences necessary for recombination. Can you provide a quote on a per replacement basis as well as for a set of 6 sequence replacements simultaneously? (We plan to make one big initial set of changes and then will do single changes a few times per month thereafter)
We think two step recombination is required since we want exact changes made (step 1 - insert a selection cassette at the change site and step 2 replace the selection marker with our custom DNA insert)
We are not picky about the destination vector - we have used EPI300
Biosafety Level BSL-2 Laboratory needed for conducting research on oncolytic viruses based on HSV1, Herpes Simplex Virus. We are looking for services for titrating how much HSV1 virus is present in our samples (e.g. plaque assays) and/or assays measuring cytopathic affect of virus in samples (CPE). We can provide cell lines for these assays if needed. If possible, we would also like to provide cancer cell lines to use for testing after titration is done in a more common cell line (e.g. vero cells).
Large chemical company needs biotechnology laboratory for Polymerase Chain Reaction (PCR) Testing for crop plants. Must be able to process single seed or leaf punch samples in high throughput (minimum 96 at a time). Experience with DNA extraction from rice. Require execution of legal agreement to enable seed companies to access testing. Lab must agree to routine proficiency testing and auditing.
Bioanalytical Laboratory needed for protein characterisation studies using analysis techniques/toolsused in a protein formulation?to demonstrate the utility of our own characterisation tools in such. We will need to have samples run on some characterisation techniques such as, LC-MS, CD?
Please provide a breakdown of what/which techniques are typically offered in a protein formulation study?
FDA GLP / GMP certified Bioanalytical Laboratory needed for Transfer of a HPLC-UV/DAD method for assay and purity of a small molecule in a complex matrix (lipid-based) to a GLP/GMP-certified lab. Transfer validation in the receiving lab and release analysis of product.
FDA cGMP Pharmaceutical analytical chemistry laboratory needed for identity testing for the following drug and excipient materials that may be used in production of clinical grade biological drug products: Pluronic F-68 1X Phosphate Buffer Saline L-Glutamine Plasmids F-17 Serum Free Media CDM4HEK293 Media Sterile water WFI Clinical 293 Suspension Cell Bank Polyethylenimine (PEI) Max. MW 25,00010X Phosphate Buffer Saline 1M Tris, pH 9.0 Tris(hydroxtmethyl) aminomethane 1M Tris-HCl, pH 8.0 10mM Tris, pH 8.0 1X Phosphate Buffer Saline 5M Sodium Chloride Solution Benzonase® endonuclease, purity grade I (?99%) Hydrochloric acid solution 6N Optiprep Phenol Red Sodium hydroxide solution 0.5N Sorbitol Sterile WFI Water 1M Magnesium Chloride Ethyl Alcohol 200 Proof
Analytical chemistry laboratory needed for testing Tocrisolve emulsion to two test methods. Homogeneous emulsion was analysed using dual scattering particles size analyser Nano DS (Cilas) after each cycle. Measurements were repeated 5 times. Number of samples : 7 ten day turnaround Acceptance Criteria: Mean droplet diameter: <250nm
Please provide a quote with costs and how much sample you would need to test to these methods?
Australia bioanalytical laboratory needed to make degalactosylated/desialylated bovine colostrum from normal bovine colostrum in various amounts.
Preparation of degalactosylated/desialylated bovine colostrum. Bovine colostrum One milligram of bovine colostrum powder was dissolved in 1 ml of 50 mM sodium phosphate buffer (pH 7.0) and incubated with 65 mU of ?-D-galactosidase (from Escherichia coli; WAKO Pure Chemical Industries, Ltd., Osaka, Japan) either with or without 65 mU of neuraminidase (sialidase from Clostridium perfringens; at 37°C for 1 h. The reaction mixture was then heated at 60°C for 10 min to deactivate the enzymes. The protein concentrations were determined, SDS-PAGE and western blotting. Degalactosylated/desialylated bovine colostrum was subjected to sodium dodecyl-polyacrylamide gel electrophoresis
PhD. University Researcher needs analytical chemistry laboratory for HPLC analysis of FLAVONOIDS, ALKALOID AND PHENOL GROUP from two plant extracts. Please specify quote.
D.Y.PATIL UNIVERSITY School of biotechnology and bioinformatics, CBD BELAPUR Navi Mumbai Mob: 9920666724
FDA and GDUFA compliant Pharmaceutical laboratory needed for USP Testing performing the tests under new chapters <661.1> and <661.2> from USP 39, regarding plastic analysis. Please send a quotation at your earliest convenience. Thanks in advance for your support and looking forward for your reply.
South America biotech manufacturer needs USA toxicology laboratory for ecotoxicology studies of a formulation containing purified water, salts, cellulases enzymes, color, odour, conservative molecules to sell product in USA in accordance with US EPA,
University Researcher needs bioanalytical laboratory for In-silico analysis to screen the laboratory of organic compound (ligands) and finds that certain organic compounds may binds in the pocket of MHC Class II molecule (receptor) that can show the binding of screened organic compound with MHC class II molecule. We want to order following test: 1. Peptide loading or Release of soluble HLA-DR Molecules. 2. Peptide loading of Cell Surface MHC Molecules. 3. FACS Analysis of Empty MHC Class II Molecules on Dendritic Cells 4. T Cell Assay 5. Transfection and site directed Mutagenesis of HLA-DR. We would like to know whether you provide the laboratory services for these test and what would be the approximate cost for these test individually.
Preclinical Laboratory needed for Research Study with FITC-induced Delayed-Type Hypersensitivity model in C57/B6 mice
Biotechnology Laboratory neded for Surface charge analysis of an intact virus like particle and comparison to the live virus (MMV). Particles must be intact when analyzing. Suggested methods include capillary gel isoelectric focusing, chromatofocusing, zeta potential, etc.I can provide samples of both.
Bioanalytical Immunology Laboratory needed Basophil Activation testing for peanut allergens. Please contact me regarding testing possibilities at your lab facility. Thanks!
LONG-TERM TESTING: FDA GLP Bioanalytical Laboratory needed for Thin Layer Chromatography for the analysis of Indium-111 bound to lower and higher molecular weight fractions of a protein. This is for release testing of a biotechnology product at the commercial stage, so appropriate laboratory practices (GLP/GMP) must apply.
ONGOING TESTING Histology and Patchology Laboratory needed for H&E staining and pathology scores done in mouse uterine tissue. This is to be done in a regular basis (around 20 uterine samples every months). I also would like to know the price per sample (incudig tissue preparation, H&E staining and pathology scores)
Biotechnology company needs FDA cGMP / GLP California microbiology/ virology laboratory needed for Virus / Bacterial Safety testing using PCR. Diseases include Hepatitis A, B, and C.
Biotechnology company wishes to outsource USP Method Bioactivity testing in Rabbits and hence seeks Quotation details.
Middle East Microbiology Laboratory needed for Helicobacter pylori research including cell culture,biochemistry,Elisa,Protein purification.....
Biotechnology company wishes to outsource the preparation of electrocompetent cells from strain of E. coli and QC step (electroporation of a BAC) with each batch so we can gauge the transformation efficiency.
Bioanalytical Laboratory needed to extract Collagen Type 2 proteins from Chicken Sternal Cartilage. This is a simple process but requires specific equipment.
United States Analytical chemistry laboratory needed for /TD GC MS VOC analysis: VOC desorbtion, chromatographic separation and detection. VOCs will be thermally desorbed from sample tubes by a Perkin Elmer Turbomatrix 350 and separated and detected by Agilent GC MS. Analytical methods will be provided.
UK or Netherlands Analytical chemistry laboratory needed for /TD GC MS VOC analysis: VOC desorbtion, chromatographic separation and detection. VOCs will be thermally desorbed from sample tubes by a Perkin Elmer Turbomatrix 350 and separated and detected by Agilent GC MS. Analytical methods will be provided.
Analytical chemistry laboratory, preferably located in the UK or Netherlands, needed for VOC desorbtion, chromatographic separation and detection /TD GC MS VOC analysis. VOCs will be thermally desorbed from sample tubes by a Perkin Elmer Turbomatrix 350 and separated and detected by Agilent GC MS. Analytical methods will be provided.
University Researcher needs Bioanaltycial Laboratory for HPLC analysis of algae Astaxanthin and other carotenoids from Haematococcus pluvialis algae powder
Europe Biotech needs FDA GMP Genetics Laboratory for Karyotype analysis in GMP with a validate method. Thank you fro your help Sonia
University Researcher needs Biotechnology Laboratory needed for biomass testing:Hydrogen and Nitrogen Analysis CHNOS analysis of two biomass ( switchgrass and tall fescue) Please send information about the amount of material which you need for this type test and price per each test.
Canada Bioanalytical Laboratory needed for materials testing of lithium soap in Bioprocessing Pilot Plant rheological characterization and tribological test of lithium soap produced by bioprocessing.
Analytical Laboratory needed for Vitamin B Testing: confirmatory testing of Vit B composition in one of our mixes. Would you please provide an estimate including TAT to test a sample for: Vit B ppm Pyridoxine-HC 10 Thiamine-HCl 5 Riboflavin 5 Nicotinic acid 5 CalciumD-(+) phantothenate 5 p-Aminobenzoic acid 5 Thiotic acid 5 Biotin 2 Folic acid 2 Vitamin B12 0.1
Bioanalytical Laboratory needed with experience in neutralization assays to set up a research program that would require performing a limited number (15-20 mouse serum samples) of neutralization assays for human papillomavirus. Please provide rough estimates of the potential costs depending on whether or not the basic materials for making the relevant pseudovirus would need to be provided.
Europe Biotechnology Researcher needs genetics laboratory for Transmission Electron Microscopy (TEM) to identify plasmid DNA replication intermediates
Biosafety Type 2 Laboratory needed for biotechnology testing or potato tissue culture,
United States Biotechnology contract research organization needed for hemagglutination inhibition antibody testing against the current human vaccine strain viruses. Estimate 30 serum samples to be tested against 3 different influenza virus strains. Dog sera will be tested.
North America USA Bioanalytical Laboratory needed for Protein analysis and digestibility corrected amino acid score (PDCAAS) of a novel protein from algae. PDCAAS determined by the methods given in sections 5.4.1, 7.2.1. and 8.0 as described in Protein Quality Evaluation, Report of the Joint FAO/WHO Expert Consultation on Protein Quality Evaluation
USA FDA GMP Bioanalytical Laboratory needed for bioavailabity testing: biosafety test for humans and animals. There are two different products: Biomass of cocoa plant cells rich in polyphenols and Biomass of a medicinal mushroom rich in polysaccharides. We will like to know how much samples do you need to realize the analysis requested? or what other information do you need from us.
Bioanalytical laboratory needed for pre-cancer ce testing: Electrophoresis assay for early detection of pre-cancerous cells from buccal mucosa. The assay if viewed under microscope and images send to analysis centre.
Materials Laboratory needed for pressure Testing of Autoclave hollow fiber membrane modules according to a specific pressurization protocol.
FDA GMP / ISO biotechnology laboratory needed for Aminoacid profile testing , PDCAAS, Free Glutamic acids,heavy metals
URGENT: ISO Microbiology laboratory needed for biological testing RODAC and RCS Biological testing. This is very urgent!!
UK Biochemistry laboratory needed for Karl Fisher Testing % moisture 40 vials of Freeze Dried biotechnology product (~0.1g mass / vial)
Biochemistry laboratory needed for Chlorophyll Extraction to get photovoltaic active chlorophyll using spinach to extract active chlorophyll.
We would like the procedure to be cost effective and fast (eg, cold pressed and then solvent extraction with acetone and hexane).
We also need a test procedure to prove that it is active preferably with a spectrograph.
Microbiology Laboratory needed for microbial efficacy study of UVC-system and hand cleaning solution
University Researcher needs Asia acoustics laboratory for ISO acoustics testing: absorption coefficient of Biomass waste material as acoustic absorber.
Biotech based environmental company for waste water treatment needs analytical lab studies and microbiology lab work.
Asia Bioanalytical laboratory needed for protein analysis: rice protein & pea protein samples. Analysis are listed below. 1. Allergen soya testing by ELISA 2. Allergens Gluten testing by ELISA 3. GMO testing by Real time PCR 4. Heavy metal testing by ICP-MS 5. Pesticide residue testing
US ISO ad FDA GMP Molecular Biology Laboratory needed for in-vitro diagnostic IVD product development feasibility and development work. Expect project to take less than 6 months. Tight timeline.
Need to work direction of Group Lead at our company.
Africa microbiology laboratory needed for lyophilization efficacy testing. Specifically on identifying microbes using molecular methods and confirming results with those in classified data bases. 1.Characterization and identification of L. bulgaricus and S. thermophilus Bacteria using PCR-based techniques.
Biotechnology Manufacturer needs USA nanotechnology laboratory for research and development studies to identify a CRL to further characterize our liposome nano particles (LNPs). In particular, interested in the DSC techniques to evaluate internal changes as results of various experimental parameters.
USA, Europe of Canada CLA Level II certified Microbiology Laboratory needed for antibody efficacy testing of our antibody fragments delivered as feed additive in an established Campylobacter jejuni broiler challenge model. Experience with Campylobacter research is a plus but not necessary.
Medicinal Chemistry Laboratory needed for natural health products testing to test algae extract for pheophorbide residue of atural health products
San Francisco energy laboratory needed for Plasma treatment and surface energy testing (pre and post) of calcium fluoride windows
Biotechnology company needs laboratory for Transmission Electron Microscopy Will send 6-8 biological (exosome preps) samples on ice. The testing should be done within 48 hours. Samples should be kept at 4 degrees C
University Researcher needs Africa biotechnology laboratory for pigment testing of pigment producing fungus. The pigment is red and soluble in organic solvents. I am working on large scale production of the pigment. I need help for structural elucudation of the pigment.
FDA GMP and ISO AAALAC Biotechnology Laboratory for Research and Development required for photo-autotrophic organisms (yeast, cyanobacteria & algae, mammalian cell line, e-coli)
India analytical chemistry laboratory needed for gel strength testing of cassia powder
Bioanalytical laboratory needed for protein analysis: Characterization and Determination in proteic content of 100-200 grammes of vegetal extract (extracted from African Thaumatococus daniellii wild forest fruit) to determine its constituents: total dry matter (of which determine the percentage content of the sweet Thaumatin I & II & al, using Kejdahl (Dosage of Nitrogen) or and Thomas or/and NIM methods, as described in the joint JEFCA FAO and World Health Organisation ), precentage humidity content,
Contract Research Organization needed with isolated Flu A and B strains for 2013-2014 season. These isolated viruses should be cultured and have the known TCID(50) values of 10(6)TCID(50) or higher. We would like to have the analytical sensitivity testing performed on these recent flu strains with commercial available testing kits. Please let us know whether this task is possible to fulfill in February 2014.
Biosimiliar Manufacturer of needs biosimiliar packaging laboratory for protien container testing
FDA GMP Bioanalytical Laboratory needed for FDA tissue protein testing using Validated Quantitative Western Blot for mammlian tissue proteins
Biotechnology Company needs Europe FDA GMP Bioanalytical laboratory for Vaccine testing, older methods, pH, Id, ICP-OES, Saccharide content, Free Saccharide, protein, particle size (Kd),
Biotechnology company needs India materials laboratory for surface area testing: test-specific surface area by BET. Pl. suggest the laboratories in india or near to our navi
US agriculture and microbiology laboratory needed for crop study using sedimentary pea gravel to grow crops from seed to harvest without any fertilizer nor soil. I need to be able to conduct these 23 test on a period basis. I didn't see food nutrition testing, but I imagine you can do that as well. Can you also study the composition of rock to determine its DNA. We want to know the varying composition of sedimentary pea gravel and what is contained within it that enables it to sustain plant production. See list below.1. Agriculture Raw Material Quality Control (QC) Testing 2. Plant Analysis Testing 3. Plant Tissue Analysis Testing 4. Agriculture Genetic Engineering 5. Composition Analysis Testing 6. Biological Activity Testing 7. Plant Biotechnology Risk Assessments 8. Total Nitrogen (TKN) Testing 9. Total Nitrogen (Combustion) Testing
Agriculture Biotechnology laboratory needed for biofuel research and development using a stain of Bactria and grape pomace to the production of Butanol for a USDA ,SBIR grant.
Biotechnology company needs USA biochemistry laboratory needed for Fast Atom Bombardment Mass Spectrometry Testing: fab-ms testing
Europe Bioanalytical Laboratory neeed for Water Testing of water samples with respect to the size of water clusters on the following devices: MultisizerT 4 COULTER COUNTER® and Zetasizer Nano ZSP under the full spectrum of measurement parameters of these two devices
Biotechnology Manufacturer needs Europe Microbiology Laboratory for microbiology testing for Microbial identification
Microbiology laboratory needed for microbiology testing to identify bacteria and fungus by PCR, RT-PCR, or any means.
INDIA MICROBIOLOGY LABORATORY NEEDED FOR MICROBIOLOGY TESTING: SIX BACTERIAL STRAINS AND TWO FUNGAL STRAINS FOR PGPR,BIOCONTROL AND BIOFERTILIZATION PROPERTIES FOR EVALUATION.
Toxicology Laboratory needed for toxicology testing: Sub-Chronic Feeding Studies, Developmental Toxicity Evaluation Studies, Single Generation Reproduction Studies and Mutagenicity Studies on two species algae. Please let me know if this is something you can do and if not please refer me to a laboratory that can.
Canada bioanalytical laboratory needed for Algae biomass testing, more specific Chlorella Biomass analysis to identify vitamins and protein content in total biomass not just algae oil.
India biotechnology laboratory needed for research and development testing: biodiesel testing and biodiesel blend testing for ongoing research and biodiesel quality monitoring.
USDA biotechnology laboratory needed for Vaccine Production of attenuated vaccines for use in aquaculture"
India microbiology labroatory needed for bioluminence testing for 160 sample of plaque in atp bioluminence assay kit and took it for a lab where luminometer testing is available which will tell how many bacteria are their in my collected plaque sample
Europe bioanalytical laboratory needed for testing OPC( oligomeric proanthocyanidins) in grape seed extract
Biotechnology Manufacturer needs preclinical CRO for starting preclinical toxicology studies for monoclonal aCD3 antibody taken orally. First study would be survey different species including monkeys to identify which one or more which can bind the anti human Mab.
University Research and Development Laboratory needs Bioanalytical Laboratory for gcms analysis of e. coli amino acids, preferably would like to outsource the hydrolyzation and the gcms, need fragmentation of amino acids to occur during gcms as well
Europe or USA biotechnology laboratory needed for lipid analysis of freeze-dried cells (geobacillus) that I require cell membrane lipids identifying and quantifying.
France or Germany Microbiology Laboratory needed for Growing Bacillus cereus spores, purifying spores and lyophilizing them. Growing up two 10L fermentor runs of B. cereus spores, purifying then (eliminating cellular debris and media residue) and lyophilizing the spores for storage and shipment. This is for experiments to be conducted in France, either during August or in early September. The product will be sent to one of the top academic research institutions in France. When it is time to run the experiments, the French commercial lab will receive a formal request will come from the university doing the work. Once commissioned, the university will need the work done in a span of 3-4 days, if possible."
Biotech company needs FDA Analytical Chemistry Laboratory for weight gain assay according to the USP Monograph for Somatropin.
FDA GMP Analytical Chemistry Laboratory needed for determination of residual DMSO in a protein sample.
India USP Microbiology Laboratory needed for testing bacterial endotoxin and water contain by coloumeter
R&D Singapore company needs Bioanalytical Laboratory that has experience working with Polysacharrides.
Germany ISO Histology Laboratory needed for GLP compliant cartilage histology to discern hyaline from fibrocartilage.
USA Biomedical Laboratory needed for Thermo gravimetric testing-Less than 10 samples
Arizona (preferred) Microbiology Laboratory needed for testing penicillium, aspergillus & mucor on a solution. Also interested in possible bacterium E. coli & salmonella. Ongoing testing, possible 50-100 per week.
USA Bioanalytical Laboratory needed for full compositional analysis of cell walls of a marine, green microalgae. Need specific polysaccharides, glycoproteins, phospholipids, etc. and amounts of components present.
FDA GLP Food Analytical Chemistry Laboratory needed for extractable testing food contact materials - extractable content according to 21 CFR 177.1660
USA FDA/GSP Bioanalytical Laboratory needed for testing single radial immunodiffusion (SRID)for three influenza antigens in the 2010-2011 Fluzone vaccine to extend expiry beyond 30 Jun 2011 in a clinical trial
St. Louis Research and Development Laboratory needed for Product Development for a source of the human breast cancer cell line PMC42 or PMC42ET
Bioanalytical laboratory needed for moisture determination testing in lyophilized products
GLP/GMP Bioanalytical Laboratory needed to test whether cell culture is contaminated by HIV, and hepatitis B and C viruses
India Toxicology Laboratory needed for toxicology testing - the number of samples is not known as of now, but should be around 10-20.
Microbiology Laboratory needed to test sample of cryopreservation media for endotoxin.
USA Bioanalytical Laboratory needed to test one sample of FBS for cell growth/plating efficiency using MRC-5, Vero-76, Hybridoma AW3.18.14 or Diploid cell lines
Biotechnology Research Company needs Europe Bioanalytical Laboratory for weekly Gc Globulin glycosylation assays to identify and show the concentrations of the three isoforms - Fully deglycosylated Serum GcGlobulin has a molecular weight of 51.4kDa, with one sugar molecule + 203 Da, the trisaccharide +656Da.
Phoenix, AZ Biotechnology Company needs Analytical Chemistry Laboratory to do organic chemical synthesis of the following:
1-pentyl-3-(1-naphthoyl)indole 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone 4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone 1-pentyl-3-(2-methoxyphenylacetyl)indole
New Zealand Analytical Chemistry Laboratory needed for testing Cholic Acid content in Bovine Bile extract.
USA/Canada GLP Bioanalytical Laboratory needed for LC-MS/MS testing of 100-400 sodium heparin plasma samples for Lenalidomide levels.
US Analytical Chemistry Laboratory needed for testing by HPLC, MS, NMR, databases to isolate and identify biological compounds suspended in distilled water.
Bioanalytical Laboratory needed for testing Axonal myelination, myelin morphology using Electron Microscopy Services.
USA Genetics/Genomics Laboratory needed for HIV sequencing by ViroSeq HIV-1 on one plasma sample, for research purposes
GMP Bioanalytical Laboratory needed for Dnase and Rnase testing for a PCR Master Mix.
UK Microbiology Laboratory needed for electrophoresis testing on Gcprotein (GcGolbulin) to assess the proportions of glycosylation: the ratios of 1, 2 or three sugar molecules attached, and the quantities.
Asia, India, USA Analytical Chemistry Laboratory needed for LC MS MS testing done for protein samples.
USA GLP Microbiology Laboratory needed for testing Metabolomics for conditioned cell culture media from yeast.
Bioanalytical Laboratory needed for testing DNA oligonucleotides to determine percent purity of approximately 10 to 20 samples. Oligonucleotides will be in the 10 to 100 mer range. The objective is to obtain an independent analysis.
USA GLP Bioanalytical Laboratory needed for simulated gastric fluid digestibility on semi-purified proteins.
GLP/GMP Bioanalytical Laboratory needed for development and routine testing by quantitive single radial immunodiffusion, sample # unknown. antibody, and reference antigen available
WestCoast USA Molecular Biology Laboratory needed to have a frozen sample of bone marrow derived cells thawed and analyzed to determine viability plus the type and numbers of stem & progenitor cells present (Mesenchymals, CD34++, etc)
GMP, ISO, USP, EP Bioanalytical Laboratory needed for the following testing: >N-terminal amino acid sequence, mass analysis (MALDI-ToF Mss, Molecular weight) >C-terminal amino acid sequence, the assignment of S-S bridge positions in amino-acid sequences, Analysis of amino-acid sequences, >Sugar chain structural analysis
USA Bioanalytical Laboratory needed for immunohistochemistry (CD31) on rat muscle that is already paraffin embedded
India Bioanalytical Laboratory needed for Isoelectric focussing of ESBL and AmpC enzymes of E coli.
USA Bioanalytical Laboratory needed for Bradykinin assays 2. PKA assays 3. Kiniogen HMWK 4.PKA testing of all plasma derivatives
Southern California Bioanalytical Laboratory needed to: 1. Prepare tissue section slides from samples of tissue isolated from laboratoty mice. 2.Perform immunostaining of these slides for human albumin, human a1-antitrypsin, human alpha fetoprotein, any human specific marker.
USA Bioanalytical Laboratory needed to have an H&E completed rat breast tumor tissue approximately 4 years old,storage in -80 freezer,12 samples
Bioanalytical Laboratory needed that has experience with CE-MS to try and Identify the peaks seen in the profile for a newly developed capillary electrophoresis method for a glycoprotein.
Bioanalytical laboratory needed to extraction and analyze (identify, quantify) non-structural carbohydrates and lipids in plant tissues (pinon & juniper); 5-200mg dry material; ~1000 samples.
Bioanalytical Laboratory needed to measure circulating mitochondrial DNA in Plasma (frozen at -70 degrees Celsius) - Measure concentrations & physical characteristics of the circulating mitochondrial DNA in the Plasma. Contact Me ASAP & Briefly Describe My Request, Not Simply The Contract Labs Test Number. Please Telephone Me ASAP & Provide $Cost and Turn-Around-Time.
Bioanalytical Laboratory needed to prepare slides. There are about 110 paraffin blocks with brain tissues, and 5 sections from each block are needed (4-5μ) in slides, in order to perform immunohistochemistry.
Preclinical Contract Research Organization needed for testing a vaccine that by Plasmodium berghei challenge of mice. Testing 5-20 groups of 5 mice each. Readouts for parasitemia and store blood for ELISA. May have small ELISA study done first.
New Zealand based manufacturing company needs Australia/New Zealand Microbiology Laboratory who can test the vapour phase activity of their product against a standard set of microorganisms as follows:
Bacteria · Staphylococcus aureus · Streptococcus agalactiae · Escherichia coli · Proteus vulgaris Yeast · Candida albicans
Current standard testing systems may need a slight modification to be effective
GLP/GMP Bioanalytical Laboratory needed for cell-culture based bioassay for human GM-CSF.
To determine the prevalence of infection of the Northeast USA Microbiology Laboratory needed for PCR on bacteria Borrelia burgdorferi in a minimum of 360 (maximum of 840) black-legged ticks (Ixodes scapularis).
Bioanalytical Laboratory needed for DNase testing of liquid samples to detect a level of DNase that degrades ng-pg quantities of DNA.
Bioanalytical Laboratory needed for testing. SUMMARY: We have about 150 samples containing double-stranded (ds) DNA fragments, which are 5-200 nucleotides (nt) in length; our samples contain no fluorescent dyes or tags. Additional sample descriptions are shown below.
If you are interested in orders of this size and frequency, please send quotes or estimates for capillary electrophoresis of routine batches of 50-200 samples, as well as a pilot study of 10-30 samples to evaluate resolution and quantitation. Please include descriptions of your instrument, capillary (i.e., length, separation matrix), and relevant protocols (e.g., denaturing agent, fluorescent dye vs. UV detection).
Sample volume & Order frequency. In the first quarter of 2010, we submitted about 400 samples to a local lab for analysis (note: the local lab closed rec
Italy Biotechnology Company needs FDA GMP Microbiology Laboratory for Mycoplasmas detection
US GLP bioanalytical laboratory to conduct GLP tests for fecal bile acids and neutral sterols.
Biotechnology Manufacturer needs West Coast USA Analytical Chemistry Laboratory for HPLC testing of ethanol fermentation: dextrin, maltotriose, maltose, d-glucose, l-lactic acid, glycerol, acetic acid, ethanol
USA GLP Bioanalytical Laboratory required for Griess Assay for Nitrate/Nitrite Analysis from Tissue Homogenate and Blood Samples. (Animal and/or Human Origin).
USA Canada Bioanalytical Laboratory with a 4 or 7 Tesla MRI instrument for imaging mice required. Would like to do T2 weighted images looking for Fe at the moment but are expecting to do T1 images looking for Gd soon.
Biotechnology Company with cancer vaccine immune modulator needs Preclinical Contract Research Organization for tumor model studies in mouse with our compound as an adjuvant to a cancer vaccine. I can provide more details but for now we are thinking about simple primary B16 and lung metastasis B16 in C57Bl6 mice with a B16 cell lysate vaccine.
Pakistan and India UKAS/ISO or equivalent Bioanalytical Laboratory required for fat analysis:extraction-soxhlet method on crushed cattle bone
USA Bioanalytical Laboratory required that that is capable of making mitocondria experiments. I am interested to investigate how a natural product can increase mitocondria efficiemcy in generating ATP.
Bioanalytical Laboratory required for bioidentity test. We are a company that specializes in peptide manufacturing.
FDA Microbiology Laboratory required to test bacteriostatic effects of compound of interest on Lawsonia strains
FDA Microbiology Laboratory required to test bacteriostatic effects of compound of interest on Mycoplasma strains
Eastern USA Bioanalytical Laboratory required for Compositional analysis of fish tissue. I would like the nonpolar lipids extracted from the samples using a Soxhlet extractor and weighed.
USA (West Coast Preferred) Analytical Chemistry Laboratory needed for Karl Fischer (coulombic) analysis of water content of lyophilized protein samples
UK OECD and GLP Bioanalytical Laboratory required for Molecular Weight Characterization of Protein Hydrolysate by the potential methods: ultrafiltration, electrophoresis, gel permeation chromatography
Also amino acid analysis of the MW fractions
Virology Laboratory needed that is able to carry out Aerovirology work. We are looking for an accredited method for the quantification of a reduction in an airborne viral titre as treated by my companies products.
US Bioanalytical Laboratory required to test the difference between our sample and a standard protein. We may need electrophoresis, LC-MSMS analysis before and after digestion ect. Please send us information about your capabilities and estimate the costs."
USA, Southern California/Southwest Bioanalytical Laboratory required for measuring the expression of two genes (to be named later) via qRT-PCR analysis on biotechnology samples. I can provide more information in subsequent discussions, however I am interested if you can provide these services, and what sort of costs, timing, etc., might be expected.
USA GLP Preclinical Contract Research Organization needed to complete the clinical chemistry pathology analysis and the histology analysis of 15 major organs.
US Biotechnology Developer needs USA bioanalytical laboratory for peptide characterization of a protein rich mixture.
Biotechnology Company needs Europe FDA GLP Preclinical Contract Research Organization for FDA IND. Murine Hindlimb Ischemia Model in immunodeficient animals to test potency of human bone-marrow derived progenitor cells
USA Biotechnology Company needs FDA GMP and GLP Bioanalytical Laboratory to analyze protein samples on Agilent 2100 bioanalyzer.
Biotechnology Company needs European Bioanalytical Preclinical laboratory for Fluorescence measurements of a fluorescent drug from plasma samples. Chromatographic separation not necessary, but may be useful.
India Biotechnology Company needs Bioanalytical Laboratory to for USP bioanalysis of peptide sample.
INda Biotechnology Company needs India Analytical Chemistry, Microbiology Laboratory for Heavy metal analysis (Pb, As, Hg, Cd), Irradiation detection, Total plate count, Yeasts and moulds, Coliforms, E. Coli, Salmonella
Cell Bank needs Microbiology, cellbiology laboratory to verify the bacterial strain of K-12 E. Coli in a working cell bank.
Canada Biotechnology Manufacturer needs USA or Canada FDA GMP Bioanalytical Laboratory for a viral clearance study on our process
Proteomics Biotechnology Company needs preclinical, oncology Contract Research Organization for Biomarker, Microarray Discovery and development study (proteomics based).
We are actually working on a compound able to inhibit a signalling pathway involved in cancer progression. Several pre-clinical trials suggest a possible role of our compound in breast and prostate cancer. The key remaining issue today is to identify a valid PD Marker prior to first administration to man.
Would it be possible to draft a summarized proposal including the following steps?:
* A: number and type of required samples (blood or tumor tissues) coming from pre-clinical studies to discover a first panel of PD markers
* (timelines to execute first discovery and validation and if possible overall cost-estimate?)
* B: number and type of required sa
East Coast Biotechnology Manufacturer needs Eastern USA Microbiology Laboratory for soil testing for Salmonella and E. coli, determine the amounts (e.g. CFU/g), isolate and capture the strains, serotyping
Biotechnology Manufacturer needs India analytical chemistry laboratory to give estimation of beta-carotene and crude phycocyanin in spirulina dried powder
Russia Biotechnology Manufacturer needs Europe FDA GLP Contract Research Organization for GLP preclinical studies for an anxiolytic drug that was succesfully developed, registered and applied in Russian Federation. The results of the studies should be valid for an appropriate application file in order to be registered in Europe.
Biotechnology Manufacturer needs USA analytical chemistry laboratory for Fisher analysis to be conducted on several lyophillized samples to determine their residual moisture content
USA Biotechnology Manufacturer needs bioanalytical laboratory for Residual solvent testing of a plasmid DNA solution.
India GMP Bioanalytical Laboratory needed for manufacturing and testing of MCB, WCB, EPC, MS, MWS etc.
Toronto Canada Bio-Analytical/Materials Laboratory required for bio-compatibility testing for SiO2 Nano-crystal generated on Bio-active glass.
Mexico FDA or near GLP Bioanalytical Laboratory required for high performance liquid chromatography analysis for biological fluid samples (aqueous Humor, or the fluid taken from the anterior chamber of the eye). Ten samples will be needed to test for the drug latanoprost, while ten samples will need to be tested for timolol. 20 samples in total including controls.
Histology Laboratory needed to test the viability of a variety of cells cryopreserved in three different cryovials. The cell types tested should include human stem cells, a primary cell culture (hepatocytes preferred) and a hybridoma cell line.
Microbiology Laboratory needed for testing Unidentified species of protozoa that appears to be Opercularia species.
Domain Eukaryota - eukaryotes Kingdom Protozoa - protozoa Subkingdom Biciliata Infrakingdom Alveolata Phylum Ciliophora - ciliates Subphylum Intramacronucleata Class Oligohymenophorea Subclass Peritrichia Order Sessilida Family Operculariidae
Description: Freshwater protozoan, non-contractile stalk. Stalk is attached to shells of freshwater snail (Planorbidae)and decaying plant matter, feeds on coccus bacteria, may feed on other small organisms, colonial, colonies are made up of dense clusters of zooids supported by a rigid branched stalk.
Location: Mendocino CA, Freshwater pond, 1/22/08
Please ignore Test Request Number 09-0015 if it has not been removed as this is an updated test request.
I have not
USA GLP Clinical/Microbiology Laboratory needed for testing using cell culture/IFA to determine presence of infectious virus (adenovirus) from ocular swab samples.
Eastern USA GLP Bioanalytical Laboratory required for the following tests: nucleotides, carbohydrates, heavy metals, and amino acids.
Eastern USA GLP Analytical Chemistry Laboratory requiried for the following testing: specific gravity (DMA46), % total dissolved solids (105C, 24hrs), % total dissolved solids (180C, 24hrs), % inorganic solids or ash (600C, 3-12hrs), % total nonvolatiles 105 (TDS105-Ash), % total nonvolatiles 180 (TDS180-Ash), ppm Arsenic (ICP), ppm Barium, (ICP), ppm Cadmium (ICP), ppm Calcium (ICP), ppm Chromium (ICP), ppm Cobalt (ICP), ppm Copper (ICP), ppm Iron (ICP), ppm Lead (ICP), ppm Magnesium (ICP), ppm Manganese (ICP), ppm Nickel (ICP), ppm Phosphorus (ICP), ppm Potassium (ICP), ppm Silicon (ICP), ppm Sodium (ICP), ppm Sulfur (ICP), ppm Tin (ICP), ppm Zinc (ICP), ppm Chloride (ISE), ppm total organic carbon (A&P method no. 9900901), ppm total protein (modified Lowry assay), ppm total nitrogen (Hach, Test 'N Tube(tm)), and ppm total Kjeldahl nitr
California Microbiology Laboratory needed for genetic analysis of an unidentified protist/protozoan.
South America Bioanalytical Laboratory needed for absorptivity testing of amino acids
USA GLP, CLIA Bioanalytical Laboratory needed for blood testing using the Tigris system on a set of blood samples previously tested with a proprietary assay. Our objective is to compare the relative performance of our assay to the Procleix Ultrio test performed according to Gen-Probes label of use. The number of samples subject to price and biostatistician input.
USA Biotechnology company needed for semi-quantitative Northern Blot analysis of 2 products on SIRT3 expression (have primer sequences)
California Radiochemistry Laboratory needed for ASTM F640 radiopacity testing of platinum wire under standard fluoroscopy conditions using X-ray, per ASTM F640
UK Bioanlytical Laboratory needed for testing for neural biopeptide bioregulator toxin
Biotechnology manufacturer needs New Zealand bioanalytical/toxicology/microbiology laboratory for testing Bovine serum for Hemoglobin level, Endotoxin level
Canada FDA GMP Biotechnology Laboratory needed for stem cell testing of plant extract in ethyl alcohol which increases the population of hair follicle stem cells . We need a testing certificate testing our lotion namely STEMCELEX second application
Biotechnology manufacturer needs analytical chemistry lab for solubility studies of a new drug in commonly used drug vehicles such as Tween*0, Chremophor etc...
Molecular biology laboratory needed for testing of cell lines. Expression of a mammalian transmembrane receptor for protein isolation and subsequent binding assays.
Bioanalytical Laboratory needed to perform PERT reverse transcriptase assay for retrovirus in unprocessed bulk ascites
Biotechnology Toxicology laboratory needed to test ADCC (antigen-dependent cytotoxicity) and complement-dependent lymphocytotoxicity (CDC) for 3 recombinant proteins
Analytical Chemistry laboratory needed for general Mycology testing conducted for the biotechnology and pharmaceutical market.
Pharmaceutical Bioanalytical Laboratory needed for All influenza A & B tests using Real-Time-PCR RT-PCR
GLP biotechnology laboratory needed for mouse ( or rabbits) are used for gene therapy with AAV. mRNA of the virus (and DNA) have to be localized by in situ hybridization
Biotechnology laboratory needed for the following:
Construction and screening of partially random (15, site specific randomization in 45 nucleotide long sequences) oligonucleotide expression libraries for specific protein-protein interactions.
Testing Requirements: 1., Oligonucleotide (~ 40-50 bases long) syntheses, and random mutagenesis at every third (defied) positions. 2., Oligonucleotide sequencing. 3., Inserting oligonucleotides into vectors and expressing into oligopeptides. 4., Expression library screening for specific protein-protein interactions (phage display or bacterial two-hybrid methods) 5., Cloning, monoclonal protein production 6., Characterization of peptide interactions (Kd, specificity)
Lab Opportunity Type: lab licensure, contract R&D,
Lab Opportunity Description: We are looking for a numbe
Biotechnology lab needed for construction and screening of partially random (15, site specific randomization in 45 nucleotide long sequences) oligonucleotide expression libraries for specific protein-protein interactions
Preclinical pharmaceuticals laboratory needed for testing for neutralization of HIV-1 (preferrential NL 4-3 virus)infectivity by selective mouse sera/antibodies
Microbiology laboratory needed to virology testing to WHO to Re-grow and re-titer viruses and bacteria from ATCC and provide samples for testing.
Analytical chemistry laboratory needed for Particle Charge measurement testing and particle size measurement, Particle in size range 10 nm to 10 micron and needs to be measured in organic solvent as well as aqs system.
Bioanalytical laboratory needed for testing Ion flux across epithelia for compund profiling
Biotechnology company developing new transfection agents for plasmid DNA needs laboratory for simple, side-by-side testing of the efficiency of our agents with commercially available agents, such as JetPEI, or even linear 25KDa PEI from Polysciences.
Biotherapeutics company needs bioanalytical laboratory for a protein binding study investigating the receptor binding activity of a proprietary peptide.
Preclinical laboratory needed for plasma testing for various rhesus monkey hormone levels from rhesus monkey plasma samples. The requested hormones are: testosterone, LH, FSH, prolactin, estradiol, GnRH. Minimal plasma volume requirement for each test should be given."
FDA GLP TOXICOLOGY LABORATORY NEEDED FOR USP ABNORMAL TOXICITY TESTING AND BIOIDENTITY TESTS ON BIOTECHNOLOGY DERIVED INSULIN API IN RABBITS AS PER USP BIOIDENTITY TESTS IN RABBITS AS PER USP
GLP Bioanalytical laboratory needed for GLP testing of residual cytokines in cell therapy product.
ISO bioanalytical laboratory needed for testing protein for Detection of detergent (type will vary); in addition detection of a salt in a protein sample (Type will vary)
Biotechnology laboratory needed for human DNA extraction, storage of blood samples, DNA probe, southern blotting
Bioanalytical laboratory needed for measuring the performance of Bio-ceramic on textile.
Biotechnology company needs FDA, GMP laboratory for USP particulate matter testing in Lyophilized vials and liquid syringes.
Biotechnology company needs FDA GMP and GLP analytical chemistry laboratory for testing residual levels of sodium butyrate in a biopharmaceutical product
Genomics laboratory needed for extraction and amplification of genomic DNA from small amounts of frozen leucocytes (about 1000 samples).
Biotechnology company needs FDA GMP, GLP bioanalytical and immunology laboratory for testing in-vitro diagnostic antigens and proteins CRP, Cancer & Tumor-Markers of native origin. Testing needed for FDA certification for importation into USA.
Protein Purification Laboratory needed to provide protein purification support services
Infectious disease laboratory needed for radiological testing of HIV cultures in Radioactive Zinc 65 solution
Preclinical laboratory needed for bioanalytical blood coagulation assays (including PT, APTT, TT and FIB) in the presence of a potential therapeutic compound. Of interest would be whether this compound promotes, inhibits(in a dose dependent manner) or does not affect the blood coagulation cascade. We will would provide the experimental design/parameters.
Large biotechnology and pharmaceuticals firm needs laboratory for FISH analysis. Determine clonality of cell population based on integration of viral vector.
Biotechnology firm needs microbiology laboratory to perform USP Purified Water Testing for: total plate count, e coli, conductivity, total organic carbon, pH
Biotechnology / biopharmaceuticals company needs Preclinical and toxicology studies rG-CSF Pharmacodynamics studies: 1) in vitro receptor binding assays (comparative to reference product) 2) in vivo rodent models (neutropenic and non-neutropenic), compare test and reference product
Toxicology 28-day repeat dose tox with local tolerance (repeated dose tox, toxicokinetics, and local tolerance.)
Pharmacodynamics studies: 1) in vitro comparative bioassays (e.g. receptor-binding studies, cell proliferation assays) 2) in vivo: erythrogenic effects of test product and the reference product should be quantitatively compared in an appropriate animal assay (polycythaemic and/or normocythaemic mouse assay)
Toxicology 3-month repeat dose tox with local tolerance in appropriate species (e.g. rat or dog)
Biotechnology company looking for GLP laboratory to conduct protein coefficent testing. Please indicate prcing, experience and turnaround time.
Virology and immunology laboratory needed for Viral re-activation in mice. Infect mice with polyomavirus. Allow virus infection to become latent (~6 mo). Treat mice with immunosuppressive test drugs and assay for virus re-activation.
Polyoma virus is BSL2. virus titers from blood, organs.
Water octanol partition coefficient, also called a LogP or Pow for biotechnology company
In vitro testing of our lead compound against HIV-1:1) A fusion assay according to Cavrois et al 2002 (Nature biotechnology 20.1151-1154)2) A CD4 ELISA assay, according to Herrera et al 2003 (Journal of Virology 77.1084-1091)3) An assay to assess anti-HIV activity of our lead compound, co-transfecting cells with vesicular stomatitis virus (VSV) as a control to confirm specifity of our compound with respect to HIV4) As assay to assess inhibition of radio-labelled chemokine ligands to CD4/CXCR4 and CCR5
TOC testing on concentrated cleaning solutions, approximately 5 samples for pharmaceuticals and biotechnology company
develop and perform a cAMP cell based bioassay for human clinical trial samples and product release/stability