Laboratory Test Request

Preclinical Pharmaceutical Non-GLP In-Vivo Studies

Project Description

Preclinical Pharmaceutical Contract Research Organization CRO needed for non-GLP in-vivo study of small protein analogs in 3 species for multiple therapeutic indications including a immunotherapeutic molecule for use in patients with advanced cancer as well as a potential agent for the prevention of HIV infection. We believe this compound has potential to treat SARS-CoV-2 associated acute respiratory distress syndrome (ARDS) . We would like to evaluate the compound in the Syrian hamster, hACE murine, and non-human primate models of SARS-VoV-2 ARDS. Animals would be randomized to receive OB-002 or placebo and exposed to the SARS-CoV-2 virus. Study endpoints include overall survival and the impact of treatment on histopathological changes in the lungs. We will also explore the impact of the timing of product exposure on clinical and histopathological outcomes.

Project Information

Number:20-00839

Industry:Pharmaceuticals

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Biopharmaceuticals,Biosimiliars,Pharmaceutical - Small Molecules,Pharmaceuticals ,Pharmaceuticals - Large Molecules,Recombiant Proteins,

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