Project Description

Contract Laboratory needed for Tobacco Cigarette Testing:

1. Provide the target specifications and upper and lower range limits for the following cigarette design parameters for each predicate and new product:
a. Puff count;
b. Filter and cigarette draw resistance (mm H?O);
c. Tobacco filler mass (mg);
d. Tobacco rod density (g/cm?);
e. Tobacco oven volatiles (OV) (%);
f. Cigarette paper base paper basis weight (g/m²);
g. Cigarette paper band porosity (CU);
h. Cigarette paper band width (mm);
i. Cigarette paper band space (mm);
j. Filter efficiency (%) [If no filter efficiency data is available for the products, include information sufficient to show that the cigarette filter is unchanged (e.g., denier per filament, total denier, and filter density)]; and
k. Filter ventilation (%).
2. Provide the upper and lower range limits for the following cigarette design parameters for each predicate and new product, unless otherwise stated:
l. Cigarette length (mm);
m. Cigarette circumference (mm);
n. Cigarette paper base paper porosity (CU);
o. Filter pressure drop (mm H?O);
p. Filter length (mm);
q. Filter density; and
r. Tipping paper length (mm).
3. FDA HPHC List (see below)
a. Measurements and Quantitative methods ISO and Intense Regime
b. National/international standards used and any deviation(s) from those standards
c. Storage conditions prior to initiating testing
HPHCs in Cigarette Smoke
Acetaldehyde
Acrolein
Acrylonitrile
4-Aminobiphenyl
1-Aminonaphthalene
2-Aminonaphthalene
Ammonia
Benzene
Benzo[a]pyrene
1,3-Butadiene
Carbon monoxide
Crotonaldehyde
Formaldehyde
Isoprene
Nicotine (total)
NNK*
NNN**
Toluene
d. TNA