Project Description

Preclinical Laboratory needed for in-vivo gastroenterology study to get a first estimation of the likelihood that a gastroenterology physical barrier might become twisted or entangled in some fashion that it could cause harm to the animal and my inference to any future human trials. Another objective is to identify any undesirable elements associated with food waste that has not had its nutrients removed in a normal manner.Need to have specially sized condom like sleeves emplaced in the stomachs of 6, genetically obese lab rats and then have their diets, weights, and stools monitored for two months. These condom like sleeves will be encapsulated in gelatin capsules. Once emplaced in the rat stomachs, they are expected to assume a round diameter two large to pass into the rat intestines. As food is pushed into the intestines, this condom like sleeve is expected to unfurl the approximate 80 cm length of the rat small intestine and act to block the transfer of food nutrients to the small intestine villi.