Project Description

GLP Toxicology laboratory for multiple USEPA-FIFRA toxicity studies (immunotoxicity, neurotoxicity, devleopment toxicology, in-vivo cytogenetics, environmental fate, etc )as per 40 CFR Part 158 and in accordance to the OPPTS(harmonized FIFRA-TSCA Guidelines) for nonfood and sanitizing uses. Studies include:
Acute oral toxicity - rat

Acute dermal toxicity

Acute inhalation toxicity - rat

Primary eye irritation - rabbit

Primary dermal irritation

Dermal sensitization

Acute neurotoxicity - rat

90-Day dermal

Developmental toxicity - one species

Salmonella typhimurium - reverse mutation assay

Mammalian cells in culture

In vivo cytogenetics

Immunotoxicity

90-Day neurotoxicity



Ecological effects data requirements.



Acute EC50 freshwater invertebrates (preferably Daphnia)

Freshwater fish LC50 (preferably rainbow trout and bluegill)

Avian oral LD50



Environmental fate data requirements.



Hydrolysis