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InSymbiosis Services :

Drug Discovery

InSymbiosis have strong experience in both discovery biology and chemistry. Utilizing a gene family approach, InSymbiosis can design, plan and execute parts or all of a client's discovery program. Our key expertise is in but not restricted to the following target families:

* G-protein coupled receptors (GPCRs) * Receptor tyrosine kinases * Kinases * Phosphatases * Hydrolases * Ion channels * Proteases

General Toxicology

* Oral, intravenous, intraperitoneal, intramuscular, intravenous infusion, subcutaneous and dermal routes of administration * Acute, subchronic, chronic, and carcinogenicity studies * Multiple species

Infusion Studies

* Intravenous and subcutaneous infusion (bolus, intermittent and continuous) * Multiple species * Validated studies durations of up to 12 months

Inhalation Studies

* Specialized inhalation methodologies * Acute, subchronic, chronic and carcinogenicity studies * Multiple species

Genetic Toxicology

* In vitro bacterial reverse mutation test * In vitro mammalian cytogenetic test * In vitro mammalian erythrocyte micronucleus assay * In vitro mouse lymphoma TK assay

Safety Pharmacology

* Central nervous system (CNS) studies in rodents and non-rodents (Functional Observational Battery or Modified Irwin Screen) * Respiratory evaluations in rodents and non-rodents * Cardiovascular studies in conscious, unrestrained naïve or non-naïve animals


Reproductive and Developmental Toxicology

Phase 1 Clinical Studies

InSymbiosis offer a variety of services to conduct and support Phase I clinical studies:

* Access to multiple Phase I units in Canada * Identify optimal Phase I unit for Client * Perform Phase I and bioequivalence studies * Provide program management and protocol design services * Interact with regulatory authority for study approval * Provide analytical and bioanalytical services including method development, method transfer and validation * Provide significant study discounts where appropriate

245 Victoria Avenue

Montréal, QC H3Z 2M6 CA