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InSymbiosis

245 Victoria Avenue

Montréal, QC H3Z 2M6 CA


InSymbiosis Services:

Drug Discovery

InSymbiosis have strong experience in both discovery biology and chemistry. Utilizing a gene family approach, InSymbiosis can design, plan and execute parts or all of a client's discovery program. Our key expertise is in but not restricted to the following target families:

* G-protein coupled receptors (GPCRs)
* Receptor tyrosine kinases
* Kinases
* Phosphatases
* Hydrolases
* Ion channels
* Proteases



General Toxicology

* Oral, intravenous, intraperitoneal, intramuscular, intravenous infusion, subcutaneous and dermal routes of administration
* Acute, subchronic, chronic, and carcinogenicity studies
* Multiple species

Infusion Studies

* Intravenous and subcutaneous infusion (bolus, intermittent and continuous)
* Multiple species
* Validated studies durations of up to 12 months

Inhalation Studies

* Specialized inhalation methodologies
* Acute, subchronic, chronic and carcinogenicity studies
* Multiple species

Genetic Toxicology

* In vitro bacterial reverse mutation test
* In vitro mammalian cytogenetic test
* In vitro mammalian erythrocyte micronucleus assay
* In vitro mouse lymphoma TK assay

Safety Pharmacology

* Central nervous system (CNS) studies in rodents and non-rodents (Functional Observational Battery or Modified Irwin Screen)
* Respiratory evaluations in rodents and non-rodents
* Cardiovascular studies in conscious, unrestrained naïve or non-naïve animals

Immunotoxicology

Reproductive and Developmental Toxicology


Phase 1 Clinical Studies

InSymbiosis offer a variety of services to conduct and support Phase I clinical studies:

* Access to multiple Phase I units in Canada
* Identify optimal Phase I unit for Client
* Perform Phase I and bioequivalence studies
* Provide program management and protocol design services
* Interact with regulatory authority for study approval
* Provide analytical and bioanalytical services including method development, method transfer and validation
* Provide significant study discounts where appropriate