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245 Victoria Avenue

Montréal, QC H3Z 2M6 CA

InSymbiosis is a contract research organization (CRO) providing customized drug development services to the global biopharmaceutical and biotechnology industries. At InSymbiosis, we utilize our expertise to plan, design, execute and deliver preclinical and Phase I clinical research and development projects on behalf of our clients. Our combination of a CRO and a consulting model provides clients the option to engage InSymbiosis as a CRO, as a consulting and project management group or a combination of the two. Our lean "virtual" company structure and our Canadian location enables us to deliver extremely productive and cost effective solutions for our clients outsourcing needs.

Technical Information:

Drug Discovery

InSymbiosis have strong experience in both discovery biology and chemistry. Utilizing a gene family approach, InSymbiosis can design, plan and execute parts or all of a client's discovery program. Our key expertise is in but not restricted to the following target families:

* G-protein coupled receptors (GPCRs)
* Receptor tyrosine kinases
* Kinases
* Phosphatases
* Hydrolases
* Ion channels
* Proteases

General Toxicology

* Oral, intravenous, intraperitoneal, intramuscular, intravenous infusion, subcutaneous and dermal routes of administration
* Acute, subchronic, chronic, and carcinogenicity studies
* Multiple species

Infusion Studies

* Intravenous and subcutaneous infusion (bolus, intermittent and continuous)
* Multiple species
* Validated studies durations of up to 12 months

Inhalation Studies

* Specialized inhalation methodologies
* Acute, subchronic, chronic and carcinogenicity studies
* Multiple species

Genetic Toxicology

* In vitro bacterial reverse mutation test
* In vitro mammalian cytogenetic test
* In vitro mammalian erythrocyte micronucleus assay
* In vitro mouse lymphoma TK assay

Safety Pharmacology

* Central nervous system (CNS) studies in rodents and non-rodents (Functional Observational Battery or Modified Irwin Screen)
* Respiratory evaluations in rodents and non-rodents
* Cardiovascular studies in conscious, unrestrained naïve or non-naïve animals


Reproductive and Developmental Toxicology

Phase 1 Clinical Studies

InSymbiosis offer a variety of services to conduct and support Phase I clinical studies:

* Access to multiple Phase I units in Canada
* Identify optimal Phase I unit for Client
* Perform Phase I and bioequivalence studies
* Provide program management and protocol design services
* Interact with regulatory authority for study approval
* Provide analytical and bioanalytical services including method development, method transfer and validation
* Provide significant study discounts where appropriate

DISCLAIMER: This Laboratory Profile was provided by the company above.