NEED LABORATORIES OR LAB SUPPLIERS?

ARE YOU A LABORATORY OR LAB SUPPLIER?

SUPPORT

Questions / Comments?
Call 1-855-377-6821or

Laboratory Test Request Details

Pharmaceuticals Test Request


Request: 18-01577

Status: Lab Needed

Closes: 12/25/2018


Title:

In vitro anti fungal efficacy test

Description:

Italy Pharmaceutical Contract Research Organization needed for In vitro efficacy test on an antifungal compound. The test is a reproduction of a previous test that whas publicized in Journal of Med Chem, details can be obtained upon request. The strains that need to be tested against are candida strains, including some azole resistant strains, more specifically Candida albicans, Candida parapsilosis, Candida krusei, and Candida tropicalis.

Reproduction of a previous test in which:

The EUCAST susceptibility testing protocol, including the update for testing of non-fermenting yeasts (Cryptococcus spp. and Geotrichum spp.), was used for the determination of the minimal inhibitory concentrations (MICs) of antifungal agents. Results were read after 24, 48, and 72 h of incubation at 37 °C. The MIC was defined as the lowest compound concentration which prevented visible growth.

Aliquots of 10 ?L were removed from the cells corresponding to the MIC, 2MIC, 4MIC, and 8MIC and serially 10-fold diluted in sterile saline, to minimize the drug carry-over. An aliquot of 10 ?L of each dilution was plated on Sabouraud dextrose agar plates. The plates were incubated at 37 °C for 24/48 h, and the number of CFUs was counted. For Cryptococcus spp. and Geotrichum spp., incubation was for 48 h to facilitate colony counting.28 When less than 100 CFU/mL was expected, 10 ?L of sample was plated without dilution.


Interested in this Pharmaceuticals Request?

Members of our Laboratory Outsourcing Network can use our online platform to communicate with the Lab Requestor, submit responses with quotes and have access to more information such as budget, location required, etc.

Create FREE Account


Other pharmaceuticals laboratory services.

Contract Laboratory can help you with all your Pharmaceuticals testing, analysis, scientific research and development, inspection, certification, engineering, failure investigation, and product development needs including:

  • Drug Discovery Testing
  • Drug Development Testing
  • Non-Clinical Study Testing
  • Preclinical Study Testing
  • Clinical Trials Testing
  • Pharmacokinetics (PK) Testing
  • Pharmacodynamics (PD) Testing
  • ADME Testing
  • Sterility Testing
  • Pyrogens Testing
  • Endotoxins Testing
  • Raw Material Testing
  • Finished Product Quality Control Release Testing
  • Real-Time Stability Testing
  • Accelerated Stability Testing
  • Method Development Testing
  • Method Validation Testing
  • Drug Release/Dissolution Testing
  • Extractable Testing
  • Leachable Testing
  • Elemental Impurities Testing
  • Packaging Testing
  • Child-Resistant Packaging Testing
  • Container Closure Integrity Testing (CCIT) Testing
  • High Throughput Screening Testing
  • Reverse Pharmacology Testing
  • Excipients Testing
  • Active Pharmaceutical Ingredient API Testing
  • Toxicology Testing
  • Toxicity Testing
  • Microbiology Testing
  • Strength Testing
  • Quality Testing
  • Purity Testing
  • Consistency Testing
  • Acid Insolubles Testing
  • Acid Solubles Testing
  • Alkali Solubles Testing
  • Alkalinity Testing
  • Appearance Testing
  • Boiling Point Testing
  • Congealing Temperature Testing
  • Flash Point Testing
  • Melting Point Testing
  • Freezing Point Testing
  • Hardness Testing
  • Heat of Combustion Testing
  • Preservatives Testing
  • Loss on Drying (under Vacuum) Testing
  • Loss on Ignition Testing
  • Melting Point Testing
  • Mineral Analysis Testing
  • Non-aqueous Titration Testing
  • Normality Testing
  • Organic Acids Testing
  • Organic Extractives Testing
  • Oxidizing Substances Testing
  • Peroxide Value Testing
  • Pour Point Testing
  • Reactivity Testing
  • Reactivity to Water Testing
  • Reducing Substances Testing
  • Refractive Index Testing
  • Residue on Evaporation Testing
  • Residue on Ignition Testing
  • Saponification Value Testing
  • Sieve Analysis Testing
  • Silver Reducing Substances Testing
  • Silicon Testing
  • Sulfur Testing
  • Sodium Testing
  • Specific Gravity Testing
  • Specific Rotation Testing
  • Sugars Testing
  • Sulfur Compounds Testing
  • Surfactants Testing
  • Talc Testing
  • Titration Curve Testing
  • Total Halides Testing
  • Total Reducing Compounds Testing
  • Unburned Carbon Testing
  • Uncarbonized Constituents Testing
  • Unsaponifiable Matter Testing
  • UV Absorption Testing
  • Volatile Matter Testing
  • Volatile Suspended Solids Testing
  • Weight Variation Testing
  • Cytotoxicity Testing
  • Elution Testing
  • Agar Diffusion Testing
  • Bioburden Testing
  • Antimicrobial Effectiveness Testing
  • Particulates Testing
  • Total Combined Mold & Yeast (TYMC) Testing
  • Total Aerobic Microbial Count (TAMC) Testing
  • Testing

Learn more about pharmaceuticals testing and research

Need Pharmaceuticals Testing or Scientific Research?

Save time and money searching. Simply, submit a Pharmaceuticals request to find the laboratories or lab suppliers that best meet your needs.

Submit Laboratory Request

Test Request: 18-01873

Large Pharmaceutical needs Analytical Chemistry Laboratory for Yellow Dye Raw Material including the following HPLC (Pu... view


Test Request: 18-01865

Large Pharmaceutical Company needs Packaging Laboratory for testing 3 different EPS foam containers in compliance to IS... view


Test Request: 18-01861

Pharmaceutical Laboratory needed for generic drug and brand drug equivalence study with physiochemical testing to show p... view