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Laboratory Test Request Details

Pharmaceutical - Small Molecules Test Request


Request: 19-00283

Status: Closed


Title:

Small Molecule Competitive Enzyme Inhibitor

Description:

Bioanalytical Laboratory needed for small molecule developmental study involving small molecule competitive enzyme inhibitor and purified human enzyme (farnesyl transferase) in a cell-free system.The enzyme required is purified human farnesyl transferase. The ideal substrate is a mutant form of HRAS, or native HRAS.


The purpose of the assay is to confirm/determine the IC50 of the farnesyl transferase inhibitor in a cell-free system. There are several published methods in the literature that could be adopted for this purpose. as part of a development programs. The bioassay would involve a small molecule competitive enzyme inhibitor and purified human enzyme (farnesyl transferase) in a cell-free system.

The enzyme required is purified human farnesyl transferase. The ideal substrate is a mutant form of HRAS, or native HRAS.
The purpose of the assay is to confirm/determine the IC50 of the farnesyl transferase inhibitor in a cell-free system. There are several published methods in the literature that could be adopted for this purpose.


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