Medical In Vivo Study


Laboratory Test Request Description

AAALAC Preclinical Musculoskeletal Contract Research Organization CRO needed for in vivo studies on skeletally mature Dorset crossbred sheep to assess the osteointegration of 8 groups of surface-treated materials (TAV and CoCr): 1.) grit blasted TAV (control), 2.) TPS coating, 3.) 3D Printed TAV, 4.) TAV Mesh, 5.) grit blasted CoCr (Control), 6.) Symmetric CoCr Bead Coating, 7.) Asymmetric CoCr Bead Coating, 8.) HA + Symmetric CoCr Bead Coating.
We will provide samples in the form of dowels. Uncoated dowels will be 10mm in diameter and 20mm in length, while bead coated dowels will have approximately 0.25mm added to their diameter. These dowels will be inserted into the proximal humerus and distal femur of the sheep (4 samples per specimen).
We want to quantify bone formation quality and quantity around the dowels at specific time points post-insertion (6 and 12 weeks) using histologic and radiographic evaluation. We are also looking to determine if osteonecrosis activity occurs in any of the groups, but are still in the process of solidifying our metrics for these measurements.
At the completion of the 12-week study, sheep will be sacrificed and samples will be sent back to us for biomechanics testing.
We are looking to get quotes for this study that will include all the testing mentioned above with n = 4 samples per group (i.e. n = 32 sheep).
Additionally, we are hoping to also get a quote for the same study using only n = 3 samples per group (i.e. n = 24 sheep) as well as if we chose to do the histological analysis ourselves.


INFORMATION

Number: 22-00055

Industry: Medical Devices



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