Contract Research Organization needed for Cardiology medical research studyto test an andotehelin receptor antagonist. Study includes the ability to conduct chronic cardiovascular surgery on large animals (pigs/sheep) .Test an endothelin receptor antagonist in an in vivo 21 day chronic experiment. A sterile infarct reperfusion injury study where anesthesized sheep have a coronary balloon catheter placed in a major coronary artery , inflated causing an ischemic episode , injection of an endothelin receptor antognist IV just prior to the release in this 1 hour ischemic period. Recover the animal for 21 days . Endpint would be planimetry and analysis of infarct size determination the left ventricle and extent of apoptosis in the heart muscle.
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