Contract Laboratory has received the following Histology Laboratory Test Requests which need to be fulfilled! These Laboratory Test Requests are received from a variety of sources ranging from start-up companies to large, multinational Fortune 500 corporations, international organizations, well-respected universities and government agencies that are actively seeking Independent, Third-Party Histology Laboratories to perform their Histology Testing, Analysis, Assays, Product Development, Scientific Research Experiments, Inspections, Certifications, and Engineering Projects. If you are a Histology laboratory that would like more information on these Histology projects, please visit our registration page or call toll us free 1-855-377-6821.
FDA GMP Medical Device Laboratory needed for biocompatibility testing of polypropylene mesh for medical use for a 510(k) application in accordance with the Blue Book Guidance G95-1, (Use of International Standard ISO-10993, Biological Evaluation of Medical Devices Part 1: Evaluation and Testing), acceptable test results should be supplied for the biological tests listed below. Standard protocols such as those identified by the USP or ASTM should be used in conducting the biocompatibility testing, if possible. Such tests should be performed on devices ready for surgical use (i.e., after manufacture, sterilization and packaging for commercial distribution).
Irritation or Intracutaneous reactivity
Systemic toxicity (acute)
Implantation (with histology of the surrounding tissue)
For products that remain in the body for greater than 30 days, the following additional tests are recommended:
Long term carcinogenicity studies should be performed with any device in which a positive genotoxitiy test result was obtained.
LONG-TERM: Preclinical CRO Immunology/Histology Laboratory needed for Non-GLP histological processing from buffered formalin fixed tissues (human and animal, size 6 mm diameter, approx. 40 um thick) into H&E stained slides (at 3 different levels) and about 10 FFPE unstained slides for further subsequent immunohistochemistry,
ONGOING TESTING Histology and Patchology Laboratory needed for H&E staining and pathology scores done in mouse uterine tissue. This is to be done in a regular basis (around 20 uterine samples every months). I also would like to know the price per sample (incudig tissue preparation, H&E staining and pathology scores)
West Coast USA Histology Laboratory needed to stain and prepare as a slide a section from each fish ovary (ovary up to 100 mm long), 150 samples
-stain and prepare as a slide a section from each pair of fish testes, 25 samples
-determine sex based on a small (5 mm) section of gonadal tissue from immature juvenile fish, 75 samples
USA Non-GLP Histology Laboratory needed for stent testing:
48 coronary stents to be embedded in SPURR, 6 sections per stent, stained with H&E and elastic trichrome. [576 slides] In addition, the 16 hearts will be transversely sectioned (6 breadloaf sections per heart), embedded in paraffin, and the mega slides stains with Carstairs. [96 slides]
(2) 10 artificial aortic valves, the 3 valve leaflets will be removed and embedded in paraffin, each leaflet will be divided into thirds and stained with H&E, Movat's and von Kossa stains: [270 slides]
The valve cage will be embedded in MMA for EXAKT grinding and staining with H&E. [10 slides]
USA Histochemistry Laboratory needed for histochemistry testing on paraffin tissue: varicella zoster virus, hh8, p16, d2-40, pg-mi, ck5/6, adipophilin. Before proceeding, please provide price quote for the following:
HSV I & II
Varicella Zoster Virus
Human Herpes Virus (HH8)
New Zealand Histology Laboratory needed for paraffin embedding of glutaraldehyde-fixed pericardial tissues. cut thin sections of each sample and stain with H&E, Mason's Trichrome, and Elastin stains. Send glass slides and disk with representative pdf images at 4x, 10x, 20x in 3 representative areas.
Europe Preclinical Contract Research Organization need for product safety, animal trial is required that will assess the safety of a new angioplasty balloon in a comparative study against against a currently marketed balloon. Two/three pigs are required for the study, whereby femoral or iliac or carotid arteries will be dilated with the concept device and a control device. The vessels will be over-expanded to approximately 120 - 200 % of their original diameter. A left or right vessel will be used for the concept device while the corresponding right or left vessel will be used as a control site for the other device. An assessment of the deliverability, balloon deflation time, thrombotic propensity, withdrawal, device safety, and initial effectiveness will be determined from this study. These characteristics will be determined from the procedure and subsequent histology data.