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Contract Laboratory has received the following Cigarrettes, Cigars and Tobacco Products Laboratory Test Requests which need to be fulfilled! These Laboratory Test Requests are received from a variety of sources ranging from start-up companies to large, multinational Fortune 500 corporations, international organizations, well-respected universities and government agencies that are actively seeking Independent, Third-Party Cigarrettes, Cigars and Tobacco Products Laboratories to perform their Cigarrettes, Cigars and Tobacco Products Testing, Analysis, Assays, Product Development, Scientific Research Experiments, Inspections, Certifications, and Engineering Projects. If you are a Cigarrettes, Cigars and Tobacco Products laboratory that would like more information on these Cigarrettes, Cigars and Tobacco Products projects, please visit our registration page or call toll us free 1-855-377-6821.
e-liquid company needs packaging laboratory for packaging teting of glass and LDPE Plastic bottles to Title 16, Part 1700.20, Testing procedure for special packaging.We have glass and plastic bottles. Our plastic bottles are LDPE. We have 3 different caps and 12 bottle sizes.
Cigarette manufacturer looking for laboratory to run testing for us on the 18 chemicals below. Ideally methods used would be those recommended by the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) http://www.coresta.org/. Requirements for testing include 10 samples. Could you advise if you would have the means to collet smoke samples and perform the tests using the HLPC, GC/MS, LC/MS, IC etc.?
HPHCs in Cigarette Smoke Family Method
Acetaldehyde Carbonyls CRM N°74 (smoke)
Acrolein Carbonyls CRM N°74 (smoke)
Acrylonitrile Carbonyls CRM N°74 (smoke)
4-Aminobiphenyl PAAS CRM in progress (smoke)
1-Aminonaphthalene PAAS CRM in progress (smoke)
2-Aminonaphthalene PAAS CRM in progress (smoke)
Ammonia NH3 CRM N°79 (tobacco and smokeless products)
Benzene VOCs CRM N°70 (smoke)
Benzo[a]pyrene BaP ISO 22634 (smoke)
1,3-Butadiene VOCs CRM N°70 (smoke)
Carbon monoxide CO
Crotonaldehyde Carbonyls CRM N°74 (smoke)
Formaldehyde Carbonyls CRM N°74 (smoke)
Isoprene VOCs CRM N°70 (smoke)
Nicotine (total) Nicotine ISO 10315 (smoke)
NNK* TSNAs CRM N°75 (smoke)
NNN** TSNAs CRM N°75 (smoke)
Toluene VOCs CRM N°70 (smoke)
Contract Laboratory needed for Tobacco Cigarette Testing:
1. Provide the target specifications and upper and lower range limits for the following cigarette design parameters for each predicate and new product:
a. Puff count;
b. Filter and cigarette draw resistance (mm H?O);
c. Tobacco filler mass (mg);
d. Tobacco rod density (g/cm?);
e. Tobacco oven volatiles (OV) (%);
f. Cigarette paper base paper basis weight (g/m²);
g. Cigarette paper band porosity (CU);
h. Cigarette paper band width (mm);
i. Cigarette paper band space (mm);
j. Filter efficiency (%) [If no filter efficiency data is available for the products, include information sufficient to show that the cigarette filter is unchanged (e.g., denier per filament, total denier, and filter density)]; and
k. Filter ventilation (%).
2. Provide the upper and lower range limits for the following cigarette design parameters for each predicate and new product, unless otherwise stated:
l. Cigarette length (mm);
m. Cigarette circumference (mm);
n. Cigarette paper base paper porosity (CU);
o. Filter pressure drop (mm H?O);
p. Filter length (mm);
q. Filter density; and
r. Tipping paper length (mm).
3. FDA HPHC List (see below)
a. Measurements and Quantitative methods ISO and Intense Regime
b. National/international standards used and any deviation(s) from those standards
c. Storage conditions prior to initiating testing
HPHCs in Cigarette Smoke
Large Canadian pharmaceutical firm needs a contract lab for Raw Materials Testing for Sorbitol that can test for lead and nickel using an AA or ICP instrument. The specifications of the tests are lead, [EP (2.4.10) limit NMT 0.5ppm], and nickel [EP (2.4.15) limit NMT 1ppm]
GMP Compliant lab to perform the following: Full Monograph Testing (individual and total) for the following items:·,Magnesium Stearate·,Maltodextin·,Polyethylene Glycol·,Silicon Dioxide,·Stearic Acid·,Croscarmellose Sodium,,Dibasic Calcium Phosphate·,Lactose Monohydrate·, Specific Rotation for Ephedrine HCl·,Diphenhydramine HCl Organic Nitrogenous Bases for a pharmaceutical company
assess the androgenic activity, in a quantitative fashion, of a single steriod with the trivial name tetrahydrogestrinone(THG) in a pilot scale study. Either an aquatic organism model or rodent model would appear adequate to provide the information desired but other potential testing types will be considered such as in-vitro receptor binding studies. The study should compare the relative androgenicity of THG to a reference compound such as testosterone
Pharmaceutical Laboratory needed for Residual Moisture Content analysis (e.g. Karl-Fisher analysis ) on lyophilized cake. All excipients in the formulation safely handled under BL 1 conditions. Fast Turn Around Times a must. Laboratory should be in the contiguous United States.
Pharmaceutical Laboratory needed for Osmolality measurements on reconsituted lyophilized formulation. All excipients in the formulation safely handled under BL 1 conditions. Fast Turn Around Times a must. Laboratory should be in the contiguous United States.
Bioanalytical Laboratory needed for Vitamin detection on Fetal Bovine Serum. Following is a list of vitamins and detectable units:
Vitamin B-12 pg/mL
Folic Acid ng/mL
Vitamin B-6 ng/mL
Thiamin B-1 ng/mL
Vitamin H Biotin pg/mL
Riboflavin B2 ng/mL
Vitamin A Retinol ng/mL
Vitamin C ng/mL
Microbiology Laboratory needed for microbial analysis SB 3112. The test material consisted of only the bacterial spores at a count of 55 x 107 cfu/ml. The tests were run in compliance with the following protocols: 1 USEPA FIFRA;GLP Standards 40 CFR 160 2 USEPA TSCA 40 CFR 792 3 Org. Economic Coop. and Dev. Principles of GLP, Annex 2, C(97)186 4 Japan Ministry of Ag, Forestry & Fisheries, Notification No. 59 Noshan 3850, Director-General of Agricultural Prod. Bureau, 10 Aug 84
Preclinical toxicology laboratory needed for Cytotoxicity studies: MEM Elution Sample Amount: 120 cm2 or 4 grams Irritation: Intracutaneous Reactivity (ISO) (w/2 extracts) Sample Amount: 240 cm2 or 8 grams Sensitization: Magnusson-Kligman (w/2 extracts) Sample Amount 600 cm2 or 32 grams (6 samples minimum) Sensitization: Local Lymph Node Assay: Sample Amount 400 cm2 or 20 grams