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SNBL Ltd.-Japan

St. Luke's Tower, 12F

Tokyo, 104-0044 JP

SNBL Ltd.-Japan Services:

SNBL services include validated analytical methods to analyze TK,PK,PD,and biomarkeres, in-house quality report writers and early clinical consultative services from our Phase I experts at two of our Phase I facilities.

Our preclinical testing services and facilities are in place to support the following programs:
1. General Toxicology-including DRF,MTD,Single,Repeat dose studies in mice, rats, rabbits, dogs and monkeys
2. Developmental and Reproductive Toxicology-in mice, rats, rabbits and monkeys
3. Pharmacology-including in vitro and in vivo safety pharmacology studies
4. Genotoxicity-in vitro and in vivo studies
5. Carcinogenicity-2 years studies in mice and rats, and 6 month studies in rasH2 transgenic and p53 knockout mice
6. Analytical Services-RI labeled and non-labeled compound analysis and immunoassay -PK/TK&PD,ADME studies,and Hormone and biomarker assay
7. Special studies-Immunotoxicology,Phototoxicity, Local irritation, etc.