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Cincinnnati Children's Translational Trials Development and Support Laboratory

3333 Burnet Avenue

Cincinnati, OH 45229-3039 US


Cincinnnati Children's Translational Trials Development and Support Laboratory Services:

The TTDSL assays include cellular and molecular testing categorized as
follows:

■Endotoxin
■Fanconi Anemia Complementation typing
■Clonogenic assays (+/- presence of drugs) for enumeration and function

■DNA/RNA Extraction and Quantitative PCR for select vector or genomic
sequences
■Clonal contribution studies including vector insertion site analysis
and sequencing (LAM PCR)
■Bacterial and Fungal Sterility (Research Only)
■Transgene detection and function assays
■Insertion site analysis (LAM and LM)
■Mycoplasma
■RCR/RCL
■Viral Vector Titration
■ELISA and western blots as techniques we are providing at a CAP level.
The laboratory has significant expertise in assays to detect,
quantitate, and sequence insertion sites, including molecular detection
and tracing of stem cell activity and lineage specific repopulation,
surveillance for potential oncogene activation, and other specific
molecular safety and efficiency concerns. The Fanconi Anemia
Complementation Assay was developed in collaboration with Arleen
Auerbach and Helmut Hannenburg and is based on cell cycle arrest
correction with complementing retroviral vectors. Assay systems for
transplant function and specific transgene correction, including
quantitative RNA and DNA molecular analysis, have been developed as a
cost-saving modular system that can be combined economically according
to the specific needs for each project. The laboratory has the ability
to modify research level molecular, cellular, and protein expression
testing to SOP driven assays appropriate for support of clinical trials.