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Buffalo BioLabs personnel have experience in all aspects of drug development from drug discovery and mechanistic analysis (e.g., development of readout systems, screening of chemical libraries, validation of hits, exploration of drug combinations) to pre-clinical animal studies (such as determination of MTD, in vivo proof of principle efficacy, optimal treatment regimens and effects in combination studies) and IND filing.
Preclinical Efficacy Studies Drug Preparation and Characterization Preparation of Cell Lines
In Vivo Operations (Rodent Models) Monitoring and data analysis: .Evaluation of mechanisms of action and biomarker Accompanying toxicology/pharmacology
Established Animal Models Subcutaneous (sc) xenografts of human cancer cell lines in athymic nude/SCID mice Lung cancer Hepatocellular carcinoma Head and neck cancer Colorectal cancer Melanoma Renal cell carcinoma Prostate cancer Breast cancer Childhood cancer
Orthotopic Xenograft Models in Mice Brain Mammary fat pad Pancreas
Syngeneic Models in Mice Breast cancer Hematological Melanoma Colon cancer Lung cancer Renal cancer Bladder cancer Ovarian cancer Head and neck cancer
Patient-derived tumors in SCID mice
NSCLC, adenocarcinoma and squamous cell Esophageal cancer, adenocarcinoma and SCC Adenocarcinoma of the pancreas Colon adenocarcinomas, primary and metastatic Melanoma Renal cell carcinoma Head & neck cancer Ovarian cancer
Transgenic Mouse Models Breast Prostate Lung Sarcoma
Rat Models Liver hepatoma Bladder cancer Colon cancer
73 High Street
Buffalo, New York 14203 US