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Buffalo BioLabs

73 High Street

Buffalo, New York 14203 US


Buffalo BioLabs Services:

Buffalo BioLabs personnel have experience in all aspects of drug development from drug discovery and mechanistic analysis (e.g., development of readout systems, screening of chemical libraries, validation of hits, exploration of drug combinations) to pre-clinical animal studies (such as determination of MTD, in vivo proof of principle efficacy, optimal treatment regimens and effects in combination studies) and IND filing.

Preclinical Efficacy Studies
Drug Preparation and Characterization
Preparation of Cell Lines

In Vivo Operations (Rodent Models)
Monitoring and data analysis:
.Evaluation of mechanisms of action and biomarker
Accompanying toxicology/pharmacology


Established Animal Models
Subcutaneous (sc) xenografts of human cancer cell lines in athymic nude/SCID mice
Lung cancer
Hepatocellular carcinoma
Head and neck cancer
Colorectal cancer
Melanoma
Renal cell carcinoma
Prostate cancer
Breast cancer
Childhood cancer

Orthotopic Xenograft Models in Mice
Brain
Mammary fat pad
Pancreas

Syngeneic Models in Mice
Breast cancer
Hematological Melanoma Colon cancer
Lung cancer
Renal cancer
Bladder cancer
Ovarian cancer
Head and neck cancer

Patient-derived tumors in SCID mice

NSCLC, adenocarcinoma and squamous cell
Esophageal cancer, adenocarcinoma and SCC
Adenocarcinoma of the pancreas
Colon adenocarcinomas, primary and metastatic
Melanoma
Renal cell carcinoma
Head & neck cancer
Ovarian cancer


Transgenic Mouse Models
Breast
Prostate
Lung
Sarcoma

Rat Models
Liver hepatoma
Bladder cancer
Colon cancer