Methodologies: Manual Patch clamp (screens and GLP-compliant) of various native or transfected ionic currents
Langendorff (isolated heart) constant pressure or flow, ECG monitoring, Left ventricular pressure (LVP), perfusion pressure, coronary flow, and sinus or paced rhythm.
ECG and blood pressure monitoring on anaesthetized animals
Isolated ventricular trabeculae mounted in vertical organ bath with electric field stimulation
Action potential kinetics analysis (Purkinje repolarisation assay) with high-resistance micro-electrode impalement