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Covance Laboratory

ZI de Limay Porcheville

Porcheville, 78440 FR

With over 20 years of Integrated Safety Science and Chemistry, Manufacturing and Control experience, Covance Porcheville provides local support for a variety of nonclinical services and global access to an extensive portfolio of drug development expertise. Covance Porcheville is a 45,000 square meter modern state of the art facility located less than 50 kilometers west of Paris. With over 140 qualified and recognized staff members (> 24 mean years of experience for scientific and > 21 years for management and technical staff), Covance Porcheville provides you with an integrated service offering to help achieve your drug development goals today and in the future. Our comprehensive suite of services, including Discovery & Translational Services, Nonclinical Safety Assessment, Program Management and PharmCMC provide both global and regional solutions for our clients.

*Four reasons to choose Covance Porcheville: 1.Science-driven Safety Science approach with more than 20 years of experience in drug development. 2.Safety Science and API synthesis on the same site: time and cost reduction in development and increase in molecule hit rate. 3.Personalized client relationships, limited number of contacts, flexibility and responsiveness to your needs. 4.Benefits of a Global CRO accessible at a local level Covance Global facilities, technology, capabilities and scientific experts help clients make fast and effective drug development decisions.

Technical Information:

*Genetic Toxicology Services:
-GLP and screening in vitro genetic toxicology studies.
-S.typhimurium, E. coli, TK6, L5178Y, human lymphocytes.
-Gene mutation, in vitro cytogenetics.
-Other in vitro services: Phototoxicity, LLNA replacements, FETAX (Frog Embryo Teratogenesis Assay Xenopus).

*General Toxicology Services:
-Standard/non standard GLP studies.
-Species : Rodents, Rabbit, Canine.
-Acute to chronic administration through several routes of administration (oral, intravenous, intramuscular, intraperitoneal, subcutaneous, intranasal).
Integrated Pathology Services.

-Clinical Pathology.
-Histopathology evaluation by Certified Veterinary Pathologists.
-GLP electronic microscopy.

*Chemistry, Manufacturing & Control solutions for small molecules (PharmCMC):
-API process development, process safety, crystallization, route scouting & troubleshooting.
-API manufacture and supply for preclinical, phase I and phase II studie.
-API characterization and pre-formulation (salt/co-crystal and polymorph screening).
-API Analytical method development, validation and release testing.
Specifically in the CMC area, Covance is a leader in:
analytical chemistry, protein chemistry, cGMP stability and release of API and drug products of all dosage forms, method development and validation, structure elucidation, impurity identification, extractables and leachables, comparator testing, cGMP cell banking, biosafety testing, bioassays, viral clearance studies, PCR screening, manufacturing support.

DISCLAIMER: This Laboratory Profile was provided by the company above.